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Membrane structured solid nanoparticles – A novel nanotechnology for delivery of cosmetic active ingredients / Gerd H. Dahms in IFSCC MAGAZINE, Vol. 8, N° 3 (07-08-09/2005)
[article]
Titre : Membrane structured solid nanoparticles – A novel nanotechnology for delivery of cosmetic active ingredients Type de document : texte imprimé Auteurs : Gerd H. Dahms, Auteur Année de publication : 2005 Article en page(s) : p. 193-198 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Biomolécules actives
Cosmétiques
Nanoparticules
Nanotechnologie
Vitamine ETags : 'Nanoparticules solides' 'Membrane structurée par des nanoparticules' 'Pénétration du tocophérol' Nanocarrière 'Fabrication continue' 'Amplification de SPF' Index. décimale : 668.5 Parfums et cosmétiques Résumé : Lipid nanoparticles have a structure similar to that of nanoemulsions. Their size ranges typically from 50 to 1000 nm. They differ from nanoemulsions in that the lipid core is a solid. The matrix consists of solid lipids or mixtures of lipids. Over the past years it has been demonstrated that solid lipid nanoparticles appear to be a promising drug carrier system for the future. Their occlusion properties reduce transepidermal water loss and can enhance penetration of active ingredients through the stratum corneum. As with all new technologies, some problems with the solid lipid nanoparticle technology need to be solved. One major problem is the homogeneous incorporation of amphiphilic active ingredients into the crystal matrix of the nanoparticles. Actives with an amphiphilic character like tocopherol or retinol cannot be kept homogeneously distributed in the wax structure during the emulsification process. Due to their hydrophilic head group they accumulate at the exterior layer of the nanoparticles together with the surfactant system used. Consequently, homogeneous release over time is not guaranteed and a burst release has to be expected. A second disadvantage is the manufacturing process. Solid lipid nanoparticles can be produced only under high pressure conditions. Also the concentration of the solid particles in the dispersion, which is added to an emulsion, is quite low. To overcome these problems membrane structured solid nanoparticles (MSSN) have been developed. These MSSN systems consist of liquid crystalline membrane systems with extremely low surfactant concentrations. The lateral movement of actives is controlled by amphiphilic solid actives such as ceramides and solid emollients. This guarantees maintenance of the advantageous properties of solid lipid nanoparticles such as retarded release of actives and their protection against chemical decomposition, but it also allows the homogeneous incorporation of amphiphilic actives. Membrane structured solid nanoparticles are produced using a continuous three-phase emulsification technique. This allows protection of heat-sensitive actives against decomposition. The concentration of nanoparticles in the MSSN dispersion can be kept higher than 60% (w/w). Even at these concentrations the nanodispersions keep their flow properties. As a result, they can be easily incorporated into the final formulation. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10494
in IFSCC MAGAZINE > Vol. 8, N° 3 (07-08-09/2005) . - p. 193-198[article]Réservation
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Code-barres Cote Support Localisation Section Disponibilité 003888 - Périodique Bibliothèque principale Documentaires Disponible The Protective Function of Compatible Solute Ectoin on the Skin, Skin Cells and its Biomolecules with Respect to UV-Radiation, Immunosupression and Membrane Damage / Joachim Bünger in IFSCC MAGAZINE, Vol. 4, N° 2 (04-05-06/2001)
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Titre : The Protective Function of Compatible Solute Ectoin on the Skin, Skin Cells and its Biomolecules with Respect to UV-Radiation, Immunosupression and Membrane Damage Type de document : texte imprimé Auteurs : Joachim Bünger, Auteur ; Joachim Degwert, Auteur ; Hansjürgen Driller, Auteur Année de publication : 2001 Article en page(s) : p. 127-131 Note générale : Bibliogr. Langues : Anglais (eng) Tags : Ectoin 'membrane protection' 'Langerhans cells' 'sun burn 'UV-induced skin damage', 'immune suppression' Index. décimale : 668.5 Parfums et cosmétiques Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10744
in IFSCC MAGAZINE > Vol. 4, N° 2 (04-05-06/2001) . - p. 127-131[article]Réservation
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Code-barres Cote Support Localisation Section Disponibilité 003871 - Périodique Bibliothèque principale Documentaires Disponible Development of leachable enalapril tablets by controlled porosity osmotic pump technique ; a unique approach to enhance its sustained release effect / Muhammad Faheem Akhtar in JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH, Vol. 19, N° 2 (03/2022)
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Titre : Development of leachable enalapril tablets by controlled porosity osmotic pump technique ; a unique approach to enhance its sustained release effect Type de document : texte imprimé Auteurs : Muhammad Faheem Akhtar, Auteur ; Hira Ashraf, Auteur ; Muhammad Uzair, Auteur ; Shabbir Ahmad, Auteur ; Akhtar Rasul, Auteur ; Ghulam Abbas, Auteur ; Shahid Shah, Auteur ; Muhammad Hanif, Auteur Année de publication : 2022 Article en page(s) : p. 497-507 Note générale : Bibliogr. Langues : Américain (ame) Catégories : Acétate de cellulose L'acétate de cellulose est une matière plastique inventée en 1865. C'est l'ester acétate de la cellulose.
Agent osmotique
Médicaments -- Mise au point
Membranes (technologie)Tags : CPOP 'Membrane lixiviable' 'Agent osmotique' 'Acétate de cellulose' 'Conception surface réponse optimale D' Index. décimale : 667.9 Revêtements et enduits Résumé : The present study aimed to design and evaluate controlled porosity osmotic pump (CPOP) tablets of enalapril maleate (ENP) being used for the treatment of hypertension. D-optimal response surface design was used, considering cellulose acetate and osmotic agents (lactose and fructose) as variables while physicochemical parameters of tablets were taken as responses. The asymmetric, leachable membrane of cellulose acetate on ENP tablets was applied and an increase in the thickness of core tablets from 5 ± 0.01 to 5.4 ± 0.17 mm was observed. The average weight of all CPOP formulations ranged from 376.7 ± 0.4 to 389.1 ± 0.3 mg and hardness was 6.2 ± 0.02 to 6.32 ± 0.06 Kg/cm2. The friability of all formulations was less than 1%. 89.53 ± 1.05% of ENP release was observed in phosphate buffer pH 6.8 after 12 h. Due to the smallest AIC (Akaike information criteria) and the greatest r2 values, zero-order release kinetics model with non-Fickian diffusion behavior was observed in all proposed formulations. f1 (difference factor) values were 1.28 ± 0.06 to 12.64 ± 0.41% and f2 (similarity factor) values were 59.75 ± 0.24 to 94.03 ± 1.36% in the same dissolution medium. pH-independent behavior was observed in pH-responsive study. Dissolution efficiency (DE) ranged from 51.49 ± 0.23 to 53.52 ± 0.52% and mean dissolution time (MDT) values ranged from 5.27 ± 0.05 to 5.59 ± 0.23 h. No interaction between the ingredients was found in FTIR analysis. The optimized formulation with improved drug release property was found stable in the accelerated stability study of six months. CPOP tablets of ENP can be considered as an effective substitute for immediate-release tablets to control hypertension in chronic conditions. Note de contenu : - MATERIALS AND METHODS : Materials - Experimental design - Preformulation studies - Preparation of core tablets - Preparation of CPOP tablets - Physicochemical evaluation of core and CPOP tablets - In vitro ENP release studies - Effects of osmotic agent and cellulose acetate concentrations - Effects of pH and agitational intensity - FTIR analysis and stability study
- RESULTS AND DISCUSSION : Preformulation properties of powder blends - Physical properties of core and CPOP tablets - D-optimal design responses - In vitro ENP release studies - Effects of osmotic agent and cellulose acetate concentrations on %ENP release - Effects of pH and agitational intensity on % ENP release through CPOP tablets - FTIR analysis and stability study
- Table 1 : Coded factors* for D-optimal design
- Table 2 : Composition of controlled porosity osmotic pump tablets with varying concentrations of osmotic agents and coating polymer. ENP, magnesium stearate, and average weight of core tablet were kept constant at 5.33% (20 mg), 1%, and 375 mg, respectively. DCM/methanol (1:1) was used as a coating solvent, PEG-400 used in coating solution was 15% of CA*
- Table 3 : Micromeritic and physicochemical properties of core and CPOP tablets
- Table 4 : Statistics obtained from in vitro model-dependent kinetic approaches of controlled porosity osmotic pump tablets
- Table 5 : Values of difference factor (f1) and similarity factor (f2) for CPOP tablets
- Table 6 : Characteristics of optimized formulation (CPOP2) stored at 40 ± 2°C/75 ± 5% RH for six monthsDOI : https://doi.org/10.1007/s11998-021-00536-3 En ligne : https://link.springer.com/content/pdf/10.1007/s11998-021-00536-3.pdf Format de la ressource électronique : Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=37281
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Code-barres Cote Support Localisation Section Disponibilité 23408 - Périodique Bibliothèque principale Documentaires Disponible