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The Protective Function of Compatible Solute Ectoin on the Skin, Skin Cells and its Biomolecules with Respect to UV-Radiation, Immunosupression and Membrane Damage / Joachim Bünger in IFSCC MAGAZINE, Vol. 4, N° 2 (04-05-06/2001)
[article]
Titre : The Protective Function of Compatible Solute Ectoin on the Skin, Skin Cells and its Biomolecules with Respect to UV-Radiation, Immunosupression and Membrane Damage Type de document : texte imprimé Auteurs : Joachim Bünger, Auteur ; Joachim Degwert, Auteur ; Hansjürgen Driller, Auteur Année de publication : 2001 Article en page(s) : p. 127-131 Note générale : Bibliogr. Langues : Anglais (eng) Tags : Ectoin 'membrane protection' 'Langerhans cells' 'sun burn 'UV-induced skin damage', 'immune suppression' Index. décimale : 668.5 Parfums et cosmétiques Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10744
in IFSCC MAGAZINE > Vol. 4, N° 2 (04-05-06/2001) . - p. 127-131[article]Réservation
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Code-barres Cote Support Localisation Section Disponibilité 003871 - Périodique Bibliothèque principale Documentaires Disponible PCA, A key NMF component, enhances micro blood circulation by modulating constitutive NO production / Kazuko Ogasahara in IFSCC MAGAZINE, Vol. 6, N° 3 (07-08-09/2003)
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Titre : PCA, A key NMF component, enhances micro blood circulation by modulating constitutive NO production Type de document : texte imprimé Auteurs : Kazuko Ogasahara, Auteur ; Manabu Kitazawa, Auteur ; Hiroshi Hayashi, Auteur Année de publication : 2003 Article en page(s) : p. 229-232 Note générale : Bibliogr. Langues : Anglais (eng) Tags : 'Amino acid transport' 'L-arginine (L-Arg)' 'Human aortic endothelial cells' 'Micro blood circulation' 'Nitric oxide (NO)' 'L-2-pyrrolidone-5-carboxylic (L-PCA)' Index. décimale : 668.5 Parfums et cosmétiques Résumé : This study revealed an intrinsic biological function of 2-pyrrolidone-5-carboxylic acid (L-PCA) to enhance micro blood circulation by modulating constitutive nitric oxide (NO) production. It is well known that NO, generated from L-arginine (L-Arg) by the action of NO synthase (NOS), plays a key role in the control of vascular tone and peripheral blood flow. In these studies we found a dose-dependent enhancement of constitutive NO production by L-PCA in human aortic endothelial cells. In contrast, D-PCA had no influence on NO production. Furthermore, L-PCA stimulated L-Arg uptake into human aortic endothelial cells in a dose-dependent manner while D-PCA had no effect, similar to its effect on NO production. L-Arg uptake and its stimulation by L-PCA to human aortic endothelial cells were suppressed with the cationic amino acid transporter. This result suggests that the enhancement of the NO production by L-PCA is due to the increase of L-Arg uptake via cationic amino acid transporter pathway. In conclusion, we found that L-PCA enhances micro blood circulation via a modulation of constitutive NO production. This intrinsic biological effect of L-PCA could lead to the development of innovative cosmetic products to care for problematic skin, such as dark circles under the eyes where a reduced micro blood circulation is one of the underlying causes. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10585
in IFSCC MAGAZINE > Vol. 6, N° 3 (07-08-09/2003) . - p. 229-232[article]Réservation
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Code-barres Cote Support Localisation Section Disponibilité 003880 - Périodique Bibliothèque principale Documentaires Disponible