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Coenzyme Q10 has anti-aging effects on human hair / Melanie Giesen in IFSCC MAGAZINE, Vol. 11, N° 1 (01-02-03/2008)
[article]
Titre : Coenzyme Q10 has anti-aging effects on human hair Type de document : texte imprimé Auteurs : Melanie Giesen, Auteur ; Thomas Welß, Auteur ; Erik Schulze zur Wiesche, Auteur ; Volker Scheunemann, Auteur ; Sabine Gruedl, Auteur ; Yasmin Oezkabakcioiglu, Auteur ; Elisabeth Poppe, Auteur ; Dirk Petersohn, Auteur Année de publication : 2008 Article en page(s) : p. 37-42 Note générale : Bibliogr. Langues : Anglais (eng) Tags : 'Coenzyme Q10' 'Follicule de cheveux' Vieillissement 'Kératinocytes externes la gaine racine' 'Synthèse kératine' Index. décimale : 668.5 Parfums et cosmétiques Résumé : Ubiquinones are the most widespread and therefore best investigated bioquinones. Due to their hydrophobic isoprenoid side chain, ubiquinones can be solubilized in organic solvents or lipids but are insoluble in water. Using a specific emulsifier system it has been possible to deliver positive effects to biological systems also from aqueous formulations. Ubiquinone-50, also referred to as coenzyme Q10, is well known in cosmetic science and especially in skin care because of its antioxidant activity. It is found in the membranes of peroxisomes, lysosomes, vesicles, the endoplasmic reticulum and notably in the inner membrane of the mitochondrion, where it is an important part of the electron transport chain. Using coenzyme Q10 in the proposed emulsifier system we could show that the molecule not only has relevance as an anti-aging bioactive in skin care but also has positive effects on the human hair follicle. The hair follicle is a complex mini organ and synthesis of hair keratin, the major component of hair fibers, is an essential prerequisite for the growth of strong and healthy hair. But like all biological systems the hair follicle, the biologically active part of the hair, also undergoes an aging process associated among other things with a decline in certain hair keratins. Due to this age-related shift in basic structural proteins of the hair shaft, mature hair often becomes fragile and difficult to manage. Therefore it is a challenge for cosmetic science to provide bioactives to fight age-related changes and maintain a youthful appearance of hair. Using cultivated hair follicle keratinocytes we identified coenzyme Q10 as a potent bioactive that stimulates the gene expression of different hair keratins, especially those which are reduced during aging processes in hair follicles. These results led us to investigate a shampoo and a tonic formulation enriched with coenzyme Q10 in a placebo-controlled panel study. In a left/right comparison a group of healthy volunteers older than 40 years of age applied the formulations daily for 4 days. Throughout the test period the gene expression of different hair keratins from plucked hair follicles was determined using quantitative polymerase chain reaction techniques. Subsequent statistical analysis revealed an increase in age-relevant hair keratins in human hair roots treated with coenzyme Q10, thus pointing out the striking benefits of coenzyme Q10 in hair care formulations. We conclude that coenzyme Q10 is an ideal ingredient for hair care formulations, providing anti-aging properties through activation of specific keratins aligned with the needs of mature hair. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10387
in IFSCC MAGAZINE > Vol. 11, N° 1 (01-02-03/2008) . - p. 37-42[article]Réservation
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Code-barres Cote Support Localisation Section Disponibilité 010282 - Périodique Bibliothèque principale Documentaires Disponible 010056 - Périodique Bibliothèque principale Documentaires Disponible Comparative topical absorption and antioxidant effectiveness of two forms of coenzyme Q10 after a single dose and after long-term supplementation in the skin of young and middle-aged subjects / Joe Vinson in IFSCC MAGAZINE, Vol. 8, N° 4 (10-11-12/2005)
[article]
Titre : Comparative topical absorption and antioxidant effectiveness of two forms of coenzyme Q10 after a single dose and after long-term supplementation in the skin of young and middle-aged subjects Type de document : texte imprimé Auteurs : Joe Vinson, Auteur ; Sunil Anamandla, Auteur Année de publication : 2005 Article en page(s) : p. 287-292 Note générale : Bibliogr. Langues : Anglais (eng) Tags : 'Coenzyme Q10' 'Peau humaine' 'Péroxydes lipidiques' Antioxydants 'Stratum corneum' Index. décimale : 668.5 Parfums et cosmétiques Résumé : Coenzyme Q10 is an endogenous antioxidant found in the skin along with vitamins A, C and E. Coenzyme Q10 is used
increasingly in cosmetic products and is advertised as a skin energizer, protector against skin aging, skin repairer, and
an anti-wrinkling agent. As the outermost layer of skin, the stratum corneum is the interface between the body and
the environment and requires antioxidants to protect it and the epidermis and dermis below it. Nutrient levels in the
stratum corneum correlate with those in the skin. Two forms of coenzyme Q10 (pure coenzyme Q10 and a yeast-based
coenzyme Q10) were investigated in a commercial vehicle. Two groups of subjects were tested aged 21-29 and 51-70,
respectively. Coenzyme Q10 absorption in the stratum corneum was determined after a 1-hour application and ethanol
extraction. Significantly more yeast coenzyme Q10 was absorbed than the pure coenzyme Q10 and the middle-aged
subjects absorbed about twice as much coenzyme Q10 as did the younger subjects. Skin antioxidants were significantly
increased by yeast coenzyme Q10 but not by pure coenzyme Q10. Peroxides declined in the stratum corneum
after twice daily application of coenzyme Q10 with both forms but the decrease was greater with the yeast form. The
older subjects had significantly higher baseline levels of lipid peroxides than did the younger group, indicating an increase
in skin oxidative damage with age. The yeast coenzyme Q10 is the superior form of coenzyme Q10 for human
skin application.Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10451
in IFSCC MAGAZINE > Vol. 8, N° 4 (10-11-12/2005) . - p. 287-292[article]Réservation
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Code-barres Cote Support Localisation Section Disponibilité 003889 - Périodique Bibliothèque principale Documentaires Disponible