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Coenzyme Q10 has anti-aging effects on human hair / Melanie Giesen in IFSCC MAGAZINE, Vol. 11, N° 1 (01-02-03/2008)
[article]
Titre : Coenzyme Q10 has anti-aging effects on human hair Type de document : texte imprimé Auteurs : Melanie Giesen, Auteur ; Thomas Welß, Auteur ; Erik Schulze zur Wiesche, Auteur ; Volker Scheunemann, Auteur ; Sabine Gruedl, Auteur ; Yasmin Oezkabakcioiglu, Auteur ; Elisabeth Poppe, Auteur ; Dirk Petersohn, Auteur Année de publication : 2008 Article en page(s) : p. 37-42 Note générale : Bibliogr. Langues : Anglais (eng) Tags : 'Coenzyme Q10' 'Follicule de cheveux' Vieillissement 'Kératinocytes externes la gaine racine' 'Synthèse kératine' Index. décimale : 668.5 Parfums et cosmétiques Résumé : Ubiquinones are the most widespread and therefore best investigated bioquinones. Due to their hydrophobic isoprenoid side chain, ubiquinones can be solubilized in organic solvents or lipids but are insoluble in water. Using a specific emulsifier system it has been possible to deliver positive effects to biological systems also from aqueous formulations. Ubiquinone-50, also referred to as coenzyme Q10, is well known in cosmetic science and especially in skin care because of its antioxidant activity. It is found in the membranes of peroxisomes, lysosomes, vesicles, the endoplasmic reticulum and notably in the inner membrane of the mitochondrion, where it is an important part of the electron transport chain. Using coenzyme Q10 in the proposed emulsifier system we could show that the molecule not only has relevance as an anti-aging bioactive in skin care but also has positive effects on the human hair follicle. The hair follicle is a complex mini organ and synthesis of hair keratin, the major component of hair fibers, is an essential prerequisite for the growth of strong and healthy hair. But like all biological systems the hair follicle, the biologically active part of the hair, also undergoes an aging process associated among other things with a decline in certain hair keratins. Due to this age-related shift in basic structural proteins of the hair shaft, mature hair often becomes fragile and difficult to manage. Therefore it is a challenge for cosmetic science to provide bioactives to fight age-related changes and maintain a youthful appearance of hair. Using cultivated hair follicle keratinocytes we identified coenzyme Q10 as a potent bioactive that stimulates the gene expression of different hair keratins, especially those which are reduced during aging processes in hair follicles. These results led us to investigate a shampoo and a tonic formulation enriched with coenzyme Q10 in a placebo-controlled panel study. In a left/right comparison a group of healthy volunteers older than 40 years of age applied the formulations daily for 4 days. Throughout the test period the gene expression of different hair keratins from plucked hair follicles was determined using quantitative polymerase chain reaction techniques. Subsequent statistical analysis revealed an increase in age-relevant hair keratins in human hair roots treated with coenzyme Q10, thus pointing out the striking benefits of coenzyme Q10 in hair care formulations. We conclude that coenzyme Q10 is an ideal ingredient for hair care formulations, providing anti-aging properties through activation of specific keratins aligned with the needs of mature hair. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10387
in IFSCC MAGAZINE > Vol. 11, N° 1 (01-02-03/2008) . - p. 37-42[article]Réservation
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Code-barres Cote Support Localisation Section Disponibilité 010282 - Périodique Bibliothèque principale Documentaires Disponible 010056 - Périodique Bibliothèque principale Documentaires Disponible Effect of the glyceride of pentadecanoic acid on energy metabolism in hair follicles / K. Adachi in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 15, N° 3 (06/1993)
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Titre : Effect of the glyceride of pentadecanoic acid on energy metabolism in hair follicles Type de document : texte imprimé Auteurs : K. Adachi, Auteur ; D. Yokoyama, Auteur ; H. Tamai, Auteur ; M. Sadai, Auteur ; K. Oba, Auteur Année de publication : 1993 Article en page(s) : p. 125–131 Note générale : Bibliogr. Langues : Anglais (eng) Tags : 'Métabolisme énergétique' 'Follicule pileux' Lapin 'Cochon de Guinée' 'Acide gras impair' Index. décimale : 668.5 Parfums et cosmétiques Résumé : L'effet du monoglycéride de l'acide pentadécanoique (PDA) dans le traitement de l'alopécie de configuration masculine a déjà été confirmé dans un test clinique en double aveugle. Afin d'étudier le mécanisme de l'effet de croissance sur les poils du PDG, les niveaux d'ATP ont été mesurés sur les follicules de poils de lapins. Les niveaux d'ATP des follicules pileux télogènes ont augmenté remarquablement avec l'application du PDG. Pour comprendre cet effet, les propriétés métaboliques de l'acide pentadécanoique (PDA) ont été étudiées en utilisant la fraction mitochondriale préparée à partir des follicules pileux de cobayes. Il a été démontré que le PDA pouvait être métabolisé dans les follicules pileux et que l'acide succinique, formé au cours du procédé de dégradation du PDA, présente une capacité de production d'ATP remarquable. Ces résultats suggèrent que l'effet de croissance du PDG dépend de sa propriété de fournir de l'énergie aux follicules pileux, et que ce mécanisme semble être dérivé de leur faculté de métaboliser un acide gras à nombre impair de carbones, le PDA. DOI : 10.1111/j.1468-2494.1993.tb00592.x En ligne : https://onlinelibrary.wiley.com/doi/10.1111/j.1468-2494.1993.tb00592.x Format de la ressource électronique : Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=26579
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 15, N° 3 (06/1993) . - p. 125–131[article]Versican expression by dermal papilla-regenerated hair follicles – a promising tool for hair-regrowth products / Jiro Kishimoto in IFSCC MAGAZINE, Vol. 7, N° 1 (01-02-03/2004)
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Titre : Versican expression by dermal papilla-regenerated hair follicles – a promising tool for hair-regrowth products Type de document : texte imprimé Auteurs : Jiro Kishimoto, Auteur ; Tsutomu Soma, Auteur ; Robert Burgeson, Auteur ; Toshihiko Hibino, Auteur Année de publication : 2004 Article en page(s) : p. 21-28 Note générale : Bibliogr. Langues : Anglais (eng) Tags : 'Follicule pileux' Protéoglycane Versicane Régéneration Index. décimale : 668.5 Parfums et cosmétiques Résumé : Hair follicle stem cells and dermal papilla cells play essential roles in the cyclical hair regeneration process. However, compared with the recent progress of follicular stem cell research, detailed analysis of dermal papilla cells is virtually unknown. We have focused on a large chondroitin sulfate proteoglycan molecule, versican, and prove its pivotal role in hair follicle induction both in vitro and in vivo. First, we examined versican expression with hair cycling by in situ hybridization (mRNA) and immunohistochemistry (protein). Results clearly showed specific versican expression in anagen onset of dermal papilla cells implying a function role of versican in hair induction. We then generated transgenic lines with LacZ or green fluorescent protein reporter genes under a versican regulatory element (promoter) control, and confirmed dermal papilla-specific activation of the reporter. These transgenic lines were utilized to isolate the dermal papilla cell population by means of a fluorescent activated cell sorter.
While freshly isolated dermal papilla cells were able to induce hair growth in a skin reconstitution assay when grafted with undifferentiated epidermal cells, this ability and versican expression were rapidly lost during passages in culture. In order to examine the functional role of versican in hair growth induction, versican full-length cDNAs were transfected into inactive passaged dermal papilla cells. Impressively, this forced expression of versican molecules partially restored hair inductivity of dermal papilla cells in a skin reconstitution assay. These results demonstrated the pivotal role of versican in hair induction both in vitro and in vivo and will connect the missing link between the signal from dermal papilla cells to follicular stem cells, and initiation of hair regeneration. We have also shown that the hair growth-promoting compound, cyclosporin A, can upregulate versican expression implying the application of a novel screening approach for hair growth-promoting compounds by monitoring versican expression as an indicator.Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10542
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