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Compatibility testing in vitro : a comparison with in vivo patch test data / Thomas Welss in IFSCC MAGAZINE, Vol. 9, N° 4 (10-11-12/2006)
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Titre : Compatibility testing in vitro : a comparison with in vivo patch test data Type de document : texte imprimé Auteurs : Thomas Welss, Auteur ; Wolfgang Matthies, Auteur ; K.-R. Schroeder, Auteur Année de publication : 2007 Article en page(s) : p. 295-302 Note générale : Bibliogr. Langues : Anglais (eng) Tags : 'Alternative aux tests sur les animaux' 'Compatibilité des tests' Cytokine 'Human risk assessment' 'Evaluation du risque humain' 'Reconstitution de l'épiderme 'Irritation la peau' Index. décimale : 668.5 Parfums et cosmétiques Résumé : For safety reasons cosmetic formulations have to be assessed for putative side effects like skin irritation. The human patch test is an appropriate method for this type of assessment, but it cannot be used for the higher throughput needed for screening innovative formulations and a distinct assessment is often difficult. The aim of this study was therefore to investigate the feasibility of using an in vitro approach for compatibility testing to determine the irritancy of surfactants. Test samples were provided by the German Society of Cosmetic Chemists (DGK), which conducted a human patch test study with the same set of samples in parallel. This gave us the unique opportunity to correlate in vitro with in vivo data. To assess irritant effects in vitro, reconstructed human epidermis was exposed to seven coded test samples consisting of individual anionic surfactants, blends of surfactants, and controls. A multiple endpoint analysis was established comprising the viability, cytotoxicity, histology, cytokine release and differential gene expression. Using this test strategy, a very good correlation was determined for our in vitro assessment of compatibility with a theoretical ranking and the human patch test data. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10429
in IFSCC MAGAZINE > Vol. 9, N° 4 (10-11-12/2006) . - p. 295-302[article]Réservation
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Code-barres Cote Support Localisation Section Disponibilité 007645 - Périodique Bibliothèque principale Documentaires Disponible Trends in ecological science. Is there a paradigm shift? / Walter Aulmann in IFSCC MAGAZINE, Vol. 9, N° 2 (04-05-06/2006)
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Titre : Trends in ecological science. Is there a paradigm shift? Type de document : texte imprimé Auteurs : Walter Aulmann, Auteur Année de publication : 2006 Article en page(s) : p. 91-95 Note générale : Bibliogr. Langues : Anglais (eng) Tags : 'Global trends' 'Dose paradigm' Persistence Accumulation 'Effect models' 'Alternative to animal tests' Index. décimale : 668.5 Parfums et cosmétiques Résumé : The cosmetic industry takes full responsability for the safety of its products. The common understanding of this responsibility has been moving lately from the basic concept of ensuring consumer protection to a wider perspective also encompassing the protection of indirectly exposed targets. Hence, a newly defined responsibility also accounts for exposure to chemicals that the possibly spread globally having an impact at any remote spot in the world. Such responsibility safeguards future human generations as well as other living organisms, both wildlife and experimental animals.
In pursuit of taking this responsibility seriously, the scientific and regulatory community has to accept new challenges. This compels us to question paradigms that were once considered indisputable. It may even be necessary to change them. The basic Paracelsus imperative of ecological and toxicological science, the dose, is such a paradigm which is increasingly called into question. The substantial erosion of the dose paradigm is illustrated by the example of persistence and bioccumulation. Likewise, in the search for in-vitro alternatives to animal tests possible future break-throughs will be linked to challenging the dose paradigm.Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10846
in IFSCC MAGAZINE > Vol. 9, N° 2 (04-05-06/2006) . - p. 91-95[article]Réservation
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Code-barres Cote Support Localisation Section Disponibilité 008185 - Périodique Bibliothèque principale Documentaires Disponible