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Skin-lightening agent with different pathways of action on melanogenesis / S. John in SOFW JOURNAL, Vol. 131, N° 7 (07/2005)
[article]
Titre : Skin-lightening agent with different pathways of action on melanogenesis Type de document : texte imprimé Auteurs : S. John, Auteur ; P. Lorenz, Auteur ; R.-D. Petersen, Auteur ; Martina Heldermann, Auteur ; S. Borchert, Auteur Année de publication : 2005 Article en page(s) : p. 40-49 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Agents de blanchiment
CosmétiquesTags : 'Bellis perennis' 'Blanchiment de la peau' 'Expression tyrosinase' 'Inhibition tyrosinase ROS 'Scannage par superoxyde (O2-)' mélanine' Mélanosome MC1-R ?-MSH Endothéline-1 (ET-1) Index. décimale : 668.5 Parfums et cosmétiques Résumé : A novel botanical ingredient -trade name: Belides - obtained from daisy flower blossoms (Bellis perennis L.) consists of bioactive constituents such a saponins (triterpene glycosides), polyphenols and polysaccharides. The presence of these constituents suggests that this active produces a variety of effects which are also used in phytomedicine. Surprisingly, Belides was found to exhibit a strong inhibitory effect on melanogenesis (patent pending). The fraction of polyphenols is known to inhibit tyrosinase enzymatic activity. results of a comparative study conducted with Belides and aubutin, used at equivalent polyphenol concentrations, revealed that Belides was about twice as active as arbutin. Tests carried out on melanoma cells (B16V) have shown that Belides controls transcription of tyrosinase expression, thus inhibiting its synthesis. In addiction, Belides has been found to significantly decrease the release of the peptide hormone endothelin (ET-1), the binding capacity of alpha-MSH (melanocyte-stimulating hormaone) on the melanocortin receptor-1 (MC1-R) and also melanosome uptake mechanisms. Furthermore, results of a pilot study performed on human volunteers demonstrate the in vivo skin-lightening efficacy of Belides. Belides is recommended for use in skin-lightening cosmetics and in case of pigmentation disorders, hyperpigmentation or age spots. Note de contenu : - INTRODUCTION : The plant
- MATERIALS AND METHODS : Manufacturing process of Belides - Total polyphenol content - Speroxide scavenging(O2-) capacity - Tyrosinase enzymatic activity - Melanin inhibition assay - Enzymatic quantification of tyrosinase expression - Endothelin-1 (ET-1) assay - The alpha-MSH assay - Phagocytosis activity of keratinocytes as a function of melanosome uptake - Skin-lightening efficacy test on human volunteers (in vivo pilot study)Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=28130
in SOFW JOURNAL > Vol. 131, N° 7 (07/2005) . - p. 40-49[article]Réservation
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Code-barres Cote Support Localisation Section Disponibilité 18185 - Périodique Bibliothèque principale Documentaires Disponible Photosynthesis-inhibiting effects of cationic biodegradable gemini surfactants / K. Kràl'ovà in TENSIDE, SURFACTANTS, DETERGENTS, Vol. 47, N° 5/2010 (09-10/2010)
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Titre : Photosynthesis-inhibiting effects of cationic biodegradable gemini surfactants Type de document : texte imprimé Auteurs : K. Kràl'ovà, Auteur ; F. Sersen, Auteur ; F. Devinsky, Auteur ; I. Lacko, Auteur Année de publication : 2010 Article en page(s) : p. 288-295 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Surfactants Tags : 'Surfactants gemini' 'Chlorella vulgaris' 'Dérivés des diamides de l'acide succinique' 'Inhibition transport photosynthétique d'électron' Chloroplastes Index. décimale : 668.1 Agents tensioactifs : savons, détergents Résumé : Cationic biodegradable gemini surfactants 3,8-diaza-4,7-dioxodecane-1,10-diylbis(alkyldimethylammonium bromide) (I) with R = C9H19–C18H37 inhibited photosynthetic electron transport (PET) in spinach chloroplasts and reduced chlorophyll (Chl) content in Chlorella vulgaris. The inhibitory effects of I intensively depended on the length of alkyl chain showing quasi-parabolic (Chlorella vulgaris) or bilinear (PET) course. IC50 value related to reduction of Chl content in C. vulgaris for dodecyl derivative was 0.6 × 10–6 mol dm–3 indicating its strong anti-algal effect. Using EPR spectroscopy as the site of inhibitory action of I in the photosynthetic apparatus the intermediates Z* and D* or their close surroundings were determined. As a further target of I inhibitory action the manganese cluster occurring on the donor side of photosystem II was estimated. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=9954
in TENSIDE, SURFACTANTS, DETERGENTS > Vol. 47, N° 5/2010 (09-10/2010) . - p. 288-295[article]Réservation
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Code-barres Cote Support Localisation Section Disponibilité 012471 - Périodique Bibliothèque principale Documentaires Disponible