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Modulation of Piezo1 influences human skin architecture and oxytocin expression / Florian Labarrade in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 45, N° 5 (10/2023)
[article]
Titre : Modulation of Piezo1 influences human skin architecture and oxytocin expression Type de document : texte imprimé Auteurs : Florian Labarrade, Auteur ; Armelle Perrin, Auteur ; Yolene Ferreira, Auteur ; Jean-Marie Botto, Auteur ; Isabelle Imbert, Auteur Année de publication : 2023 Article en page(s) : p. 604-611 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Anticorps
Barrière cutanée
Cadhérine
Dermatologie
Mécanosensorialité
Ocytocine
Peau -- Anatomie
Peau -- Physiologie
Statistiques
ToucherIndex. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Throughout our existence, the skin senses and analyses the mechanical forces imposed by the environment. In response to these environmental forces, skin can deform itself and achieve a biological response. The subsequent cutaneous plasticity emerges from mechanical properties arising from the collective action of the skin cells, particularly keratinocytes, that govern the tensile strength via cell-to-cell adhesions and via cell–matrix adhesion structures. In addition to serving as force-bearing entities, keratinocytes respond to forces by activating signalling pathways to control their own fate and function. To detect and adapt to mechanical signals, keratinocytes possess a panel of sensory receptors and junctional intercellular structures. Mechanically activated ion channel Piezo1 has been described as a force sensor and as being involved in pleasant touch perception. In this study, relationships between Piezo1 modulation and oxytocin synthesis were investigated.
- Methods : The expression of Piezo1 in the skin was studied and compared with the expression of TRPV1. Dooku1 antagonist and Jedi1 agonist were used to modulate Piezo1. The level of E-cadherin and oxytocin was monitored in ex vivo skin biopsies by immunodetection.
- Results : Taken together, our results illustrate the major role of mechanosensitive ion channel Piezo1 in skin barrier integrity, and in peripheral oxytocin synthesis in the skin.
- Conclusion : In conclusion, this study highlights the relationships between pleasant touch, soft touch and local oxytocin synthesis.Note de contenu : - Antibodies
- Immunohistological fluorescent studies
- Haematoxylin and eosin staining
- Statistical analysisDOI : https://doi.org/10.1111/ics.12864 En ligne : https://drive.google.com/file/d/1Rhjjp-MCVbwC2qcra5JkPYUYHd34CP92/view?usp=drive [...] Format de la ressource électronique : Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=40081
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 45, N° 5 (10/2023) . - p. 604-611[article]Multidirectional activity of bakuchiol against cellular mechanisms of facial ageing - Experimental evidence for a holistic treatment approach / Anika Bluemke in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 44, N° 3 (06/2022)
[article]
Titre : Multidirectional activity of bakuchiol against cellular mechanisms of facial ageing - Experimental evidence for a holistic treatment approach Type de document : document électronique Auteurs : Anika Bluemke, Auteur ; Annika P. Ring, Auteur ; Jeannine Immeyer, Auteur ; Anke Hoff, Auteur ; Tanya Eisenberg, Auteur ; Wolfram Gerwat, Auteur ; Franziska Meyer, Auteur ; Sabrina Breitkreutz, Auteur ; Lina M. Klinger, Auteur ; Johanna M. Brandner, Auteur ; Marietta Seifert, Auteur ; Doerte Segger, Auteur ; Frank Rippke, Auteur ; Dorothea Schweiger, Auteur Année de publication : 2022 Article en page(s) : p. 377-393 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge
BakuchiolLe Bakuchiol est un méroterpène (composé chimique à structure terpénoïde partielle) de la classe des terpénophénols. On le trouve dans Psoralea corylifolia et dans Otholobium pubescens. (wikipedia)
Dermo-cosmétologie
Ingrédients cosmétiques
Justification de l'allégation
Peau -- Anatomie
Peau -- Physiologie
Vitamine AIndex. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Skin ageing is a multifactorial process involving formation of reactive oxygen species, consecutive inflammation with reduced epidermal and dermal cell viability and resulting damage to the extracellular matrix. Effective dermocosmetic treatment modalities should ideally address these hallmarks in a holistic approach. Here, we determined the corresponding activity profile of bakuchiol, a plant-derived meroterpene, in an array of in vitro, ex vivo and in vivo studies and compared it to retinol, currently considered as gold standard in topical antiageing cosmetics.
- Methods : The antioxidative capacity and power of bakuchiol and retinol were analysed by measuring 2,2′-diphenyl-1-picrylhydrazyl (DPPH) reduction via its absorption decay and electron spin resonance spectroscopy, respectively. Effects on prostaglandin E2 (PGE2), macrophage migration inhibitory factor (MIF), fibroblast growth factor 7 (FGF7), collagen type I and VII (COL1A1, COL7A1), fibronectin (FN) levels as well as the metabolization of water-soluble tetrazolium 1 (WST-1) were determined in human dermal fibroblasts. Epidermal regeneration was assessed utilizing an in vitro wound healing model. FN protein levels were analysed ex vivo after treatment with a formulation containing bakuchiol, retinol or vehicle using suction blister fluid. Skin condition improvement was determined in vivo in a split-face comparison study after application of bakuchiol or vehicle.
- Results : In contrast to retinol, bakuchiol demonstrated high antioxidative efficacy. Levels of PGE2 and MIF were significantly decreased by both bakuchiol and retinol. Bakuchiol but not retinol significantly increased FGF7 protein levels. WST-1 metabolization levels were significantly augmented by bakuchiol and retinol. Bakuchiol and retinol application led to a significant augmentation of COL1A1, COL7A1 and FN protein levels. Wounds supplemented with bakuchiol but not retinol displayed a significant increase in epidermis regeneration. Clinically, areas treated with a bakuchiol-containing formulation showed a statistically significant increase in FN protein values after a 4-week application compared to untreated areas and areas treated with vehicle.
- Conclusion : These data provide evidence for the multidirectional efficacy of bakuchiol against cellular hallmarks of skin ageing. Its activity profile shares some common features with retinol but demonstrates several hitherto unknown biopositive effects in our studies, namely stimulation of the critical extracellular matrix component FN, and accelerated epidermal regeneration and wound healing.Note de contenu : - MATERIALS AND METHODS : Test materials - In vitro studies - In vivo studies I and II - Study I : Ex vivo determination of FN protein levels - Study II : In vivo determination of skin condition improvement - Statistical analysis
- RESULTS : In vitro studies - Study I: Ex vivo determination of FN protein levels - Study II : In vivo determination of skin condition improvement
In vivo studies : TolerabilityDOI : https://doi.org/10.1111/ics.12784 En ligne : https://drive.google.com/file/d/1OjIAr7zsVF9vrJc0smRlFvAEIpWDsK46/view?usp=shari [...] Format de la ressource électronique : Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=38137
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 44, N° 3 (06/2022) . - p. 377-393[article]Multifaceted amelioration of cutaneous photoageing by (0.3%) retinol / Kieran T. Mellody in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 44, N° 6 (12/2022)
[article]
Titre : Multifaceted amelioration of cutaneous photoageing by (0.3%) retinol Type de document : document électronique Auteurs : Kieran T. Mellody, Auteur ; Eleanor J. Bradley, Auteur ; Bezaleel Mambwe, Auteur ; Lindsay F. Cotterell, Auteur ; Orsolya Kiss, Auteur ; Poonam Halai, Auteur ; Zeena Loftus, Auteur ; Mike Bell, Auteur ; Tamara W. Griffiths, Auteur ; Christopher E. M. Griffiths, Auteur ; Rachel E. B. Watson, Auteur Année de publication : 2022 Article en page(s) : p. 625-635 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Anatomie
Antiâge
Barrière cutanée
Formulation (Génie chimique)
Peau -- Anatomie
Peau -- Physiologie
Peau noire -- Soins et hygiène
Photodétérioration
Vitamine AIndex. décimale : 668.5 Parfums et cosmétiques Résumé : - BACKGROUND : Although retinol skin care products improve the appearance of photoaged skin, there is a need for an effective retinol concentration that provides skin benefits without irritation.
- OBJECTIVE : To compare the efficacy of topical 0.1%, 0.3% and 1% retinol in remodelling the cutaneous architecture in an in vivo experimental patch test study, and to determine tolerance of the most effective formulations when used in a daily in-use escalation study.
- METHODS : For the patch test study, retinol products were applied under occlusion, to the extensor forearm of photoaged volunteers (n = 5 ; age range 66–84 years), and 3 mm skin biopsies obtained after 12 days. Effects of different retinol concentrations, and a vehicle control, on key epidermal and dermal biomarkers of cellular proliferation and dermal remodelling were compared to untreated baseline. Separately, participants (n = 218) recorded their tolerance to 0.3 % or 1 % retinol over a six-week, approved regimen, which gradually increased the facial applications to once nightly.
- RESULTS : Retinol treatment induced a stepwise increase in epidermal thickness and induced the expression of stratum corneum proteins, filaggrin and KPRP. 0.3 % retinol and 1 % retinol were comparably effective at inducing keratinocyte proliferation in the epidermis, whilst reducing e-cadherin expression. Fibrillin-rich microfibril deposition was increased following treatment with 0.3% and 1% retinol (p < 0.01) ; other dermal components remained unaltered (e.g., fibronectin, collagen fibrils, elastin), and no evidence of local inflammation was detected. The in-use study found that 0.3% retinol was better tolerated than 1 % retinol, with fewer and milder adverse events reported (χ2(1) = 23.97 ; p < 0.001).
- CONCLUSIONS : This study suggests that 1 % and 0.3 % retinol concentrations were similarly effective at remodelling photodamaged skin in an in vivo model of long-term use. Use of 0.3 % retinol in the escalation study was associated with fewer adverse reactions when applied daily. Hence, 0.3% retinol may be better tolerated than 1 % retinol, thereby allowing longer-term topical application.Note de contenu : - Tissue sample acquisition and preparation
- Biomarker detection and imaging
- Image analysis
- Statistical analysis
- Consumer tolerance study
- Tolerance profile study analysisDOI : https://doi.org/10.1111/ics.12799 En ligne : https://drive.google.com/file/d/1C2tBcYfsMW37WaPs8Q-k0HjuTCahQAuk/view?usp=share [...] Format de la ressource électronique : Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=38387
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 44, N° 6 (12/2022) . - p. 625-635[article]Naturally occurring w-Hydroxyacids / P. W. Wertz in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 40, N° 1 (02/2018)
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Titre : Naturally occurring w-Hydroxyacids Type de document : texte imprimé Auteurs : P. W. Wertz, Auteur Année de publication : 2018 Article en page(s) : p. 31-33 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Barrière cutanée
CéramidesUn céramide est un sphingolipide résultant de la combinaison d'un acide gras avec la sphingosine via une liaison amide. On trouve de telles molécules en abondance dans les membranes cellulaires, où elles entrent notamment dans la constitution des sphingomyélines. Les céramides ne jouent pas qu'un rôle structurel dans les membranes biologiques, et peuvent également revêtir des fonctions de signalisation lipidique. Leurs actions les mieux comprises vont de la différenciation cellulaire à la mort cellulaire programmée (apoptose) en passant par la prolifération cellulaire.
Les acides gras qui les constituent ont généralement un nombre pair (de 16 à 24) d'atomes de carbone, sont saturés ou monoinsaturés, et sont souvent α-hydroxylés.
La plupart des céramides n'existent pas à l'état naturel si ce n'est comme précurseurs de la biosynthèse des sphingolipides par une réaction d'addition sur la fonction alcool primaire de la sphingosine. (Wikipedia)
Chimie analytique
Glucosylcéramide
Peau -- PhysiologieIndex. décimale : 668.5 Parfums et cosmétiques Résumé : w-Hydroxyacids are fatty acids bearing a hydroxyl group on the terminal carbon. They are found in mammals and higher plants and are often involved in providing a permeability barrier, the primary purpose of which is to reduce water loss. Some w-hydroxyacid derivatives may be involved in waterproofing and signalling. The purpose of this review was to survey the known natural sources of w-hydroxyacids. w-Hydroxyacids are produced by two different P450-dependent mechanisms. The longer (30–34 carbons) w-hydroxyacids are produced by chain extension from palmitic acid until the chain extends across the membrane in which the extension is taking place, and then the terminal carbon is hydroxylated. Shorter fatty acids can be hydroxylated directly to produce C16 and C18 ω-hydroxyacids found in plants and 20-eicosatetraenoic acid (20-HETE) by a different P450. The C16 and C18 ω-hydroxyacids are components of polymers in plants. The long-chain w-hydroxyacids are found in epidermal sphingolipids, in giant-ring lactones from the sebum of members of the equidae, as a component of meibum and in carnauba wax and wool wax. Note de contenu : - Mammalian epidermal sphingolipids
- Meibum
- Equine sebum
- 20-HETE
- Carnauba wax
- Plant cuticle
- SuberinDOI : 10.1111/ics.12432 En ligne : http://onlinelibrary.wiley.com/doi/10.1111/ics.12432 Format de la ressource électronique : Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=29893
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Code-barres Cote Support Localisation Section Disponibilité 19964 - Périodique Bibliothèque principale Documentaires Disponible 19529 - Périodique Bibliothèque principale Documentaires Disponible A new matrikine-derived peptide up-regulates longevity genes for improving extracellular matrix architecture and connections of dermal cell with its matrix / R. Leroux in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 42, N° 1 (02/2020)
[article]
Titre : A new matrikine-derived peptide up-regulates longevity genes for improving extracellular matrix architecture and connections of dermal cell with its matrix Type de document : texte imprimé Auteurs : R. Leroux, Auteur ; Caroline Ringenbach, Auteur ; Thibault Marchand, Auteur ; Olivier Peschard, Auteur ; Philippe Mondon, Auteur ; Pascaline Criton, Auteur Année de publication : 2020 Article en page(s) : p. 53-59 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Cellules -- Cultures et milieux de culture
Composés organiques -- Synthèse
Dermatologie
Elisa, TestLe test ELISA est une méthode de laboratoire qualifiée d'immuno-enzymatique. Il s'agit d'un test immunologique, car il a pour principal objectif de mettre en évidence la présence d'anticorps ou d'antigènes spécifiques à une pathologie, dans un échantillon de sang. Cet examen utilise une protéine appelée enzyme, qui va se fixer à certains constituants spécifiques de la maladie, et par repérage et quantification de cette enzyme, la maladie pourra être affirmée, ainsi que son intensité évaluée.
Génétique
Peau -- Anatomie
Peau -- Physiologie
Peptides
ProtéomiqueLa protéomique désigne la science qui étudie les protéomes, c'est-à -dire l'ensemble des protéines d'une cellule, d'un organite, d'un tissu, d'un organe ou d'un organisme à un moment donné et sous des conditions données.
Dans la pratique, la protéomique s'attache à identifier de manière globale les protéines extraites d'une culture cellulaire, d'un tissu ou d'un fluide biologique, leur localisation dans les compartiments cellulaires, leurs éventuelles modifications post-traductionnelles ainsi que leur quantité.
Elle permet de quantifier les variations de leur taux d'expression en fonction du temps, de leur environnement, de leur état de développement, de leur état physiologique et pathologique, de l'espèce d'origine. Elle étudie aussi les interactions que les protéines ont avec d'autres protéines, avec l'ADN ou l'ARN, ou d'autres substances.
La protéomique fonctionnelle étudie les fonctions de chaque protéine.
La protéomique étudie enfin la structure primaire, secondaire et tertiaire des protéines. (Wikipedia)Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Skin extracellular matrix (ECM) is a dense and well-organized structure produced by fibroblasts. This ECM transduces environmental mechano-signals to cell nucleus through the integrin–actin complex, thus triggering ECM protein syntheses. The aim of this study was to discover a novel peptide, structurally related to dermal matrikines, that promotes syntheses of ECM components.
- Methods and results : Screening tests with 120 peptides were carried out by using normal dermal human fibroblasts (HF). As a result, one candidate of interest was isolated, the N-Prolyl Palmitoyl Tripeptide-56 Acetate (PP56), which increases collagen and fibronectin productions at gene and/or protein levels. Using liquid chromatography–tandem mass spectrometry (LC-MS/MS), a recent and innovative analytical technology, in addition to more traditional techniques, it was showed that two metabolic pathways were significantly modulated: one for collagen production and one for actin. Moreover, this peptide up-regulated the transcription of Forkhead Box O (FOXO) and sestrin messenger RNAs (mRNA), leading to production of proteins involved into longevity and more recently in collagen production.
- Results : Results indicated that this peptide is a potential candidate to improve ECM density and organization in a new way.DOI : 10.1111/ics.12584 Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=33679
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Code-barres Cote Support Localisation Section Disponibilité 21486 - Périodique Bibliothèque principale Documentaires Disponible Niacinamide mitigates SASP-related inflammation induced by environmental stressors in human epidermal keratinocytes and skin / John C. Bierman in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 42, N° 5 (10/2021)
PermalinkNovel double staining of the stratum corneum with fluorescent ε-poly-l-lysine and anionic dextran / Moemi Yoshida in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 45, N° 3 (06/2023)
PermalinkA novel water-in-oil emulsion with a lecithin-modified bentonite prevents skin damage from urban dust and cedar pollen / Tetsuro Iwanaga in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 42, N° 3 (06/2020)
PermalinkObserver-blind randomized controlled study of a cosmetic blend of safflower, olive and other plant oils in the improvement of scar and striae appearance / Stephan Bielfeldt in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 40, N° 1 (02/2018)
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PermalinkOverall renewal of skin lipids with Vetiver extract for a complete anti-ageing strategy / Morgane de Tollenaere in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 43, N° 2 (04/2021)
PermalinkOxidative stress – a key emerging impact factor in health, ageing, lifestyle and aesthetics / K. Kandola in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 37, suppl. 2 (12/2015)
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PermalinkLa peau / Alexandre Mélissopoulos / Paris : Technique & Documentation - Lavoisier (1998)
PermalinkPhotoageing-related skin changes in different age groups: a clinical evaluation by biophysical and imaging techniques / M. M. Fossa Shirata in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 41, N° 3 (06/2019)
PermalinkPhotoprotection in changing times – UV filter efficacy and safety, sensitization processes and regulatory aspects / C. Stiefel in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 37, N° 1 (02/2015)
PermalinkPotential anti-ageing effect of chondroitin sulphate through skin regeneration / D. Min in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 42, N° 5 (10/2021)
PermalinkPreliminary performance data of the RHE/IL-18 assay performed on SkinEthic™ RHE for the identification of contact sensitizers / Eric Andres in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 39, N° 2 (04/2017)
PermalinkQuantifying dyspigmentation in facial skin ageing : an explorative study / G. Dobos in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 37, N° 5 (10/2015)
PermalinkRedox proteomic evaluation of oxidative modification and recovery in a 3D reconstituted human skin tissue model exposed to UVB / J. M. Dyer in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 39, N° 2 (04/2017)
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