| Titre : |
5-a reductase inhibition by Epilobioum fleischeri extract modulates facial microbiota structure |
| Type de document : |
document électronique |
| Auteurs : |
Riccardo Sfriso, Auteur ; Joshua Claypool, Auteur ; Magalie Roche, Auteur ; Dominik Imfeld, Auteur |
| Année de publication : |
2022 |
| Article en page(s) : |
p. 440-452 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Antienzymes
Extraits de plantes:Extraits (pharmacie)
Formulation (Génie chimique)
Justification de l'allégation
Microbiome cutané
Microbiote cutané
Peau -- Soins et hygiène
RéductaseUne réductase est une enzyme qui diminue l'énergie d'activation d'une réaction d'oxydo-réduction. (Wikipedia)
Visage -- Soins et hygiène
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
- Background : Facial skin is a particularly complex environment made of different skin types such as sebaceous (forehead) and dry (cheeks). The skin microbiota composition on different facial sites has not yet been addressed.
- Methods : We conducted a 4-week-long, single-centre, randomized and placebo-controlled clinical study involving 23 Caucasian females. We assessed both bacterial composition on five different facial areas and the microbiome modulatory effects resulting from the topical application of a plant extract (Epilobium fleischeri). Skin microbiome samples were collected before and after 4 weeks of product application. Microbiota profiling was performed via 16S rRNA gene sequencing, and relative abundance data were used to calculate differentials via a multinomial regression model.
- Results : Via ‘reference frames’, we observed shifts in microbial composition after 4 weeks of twice-daily product application and identify certain microbiota species, which were positively associated with the application of the product containing the Epilobium fleischeri extract. Staphylococcus hominis, Staphylococcus epidermidis, and Micrococcus yunnanensis appeared to be significantly enriched in the final microbiota composition of the active treatment group.
- Conclusion : Facial skin was found to be colonized by an heterogenous microbiota, and the Epilobium fleischeri extract had a modulatory effect on commensal bacteria on the different facial sites. |
| Note de contenu : |
- INTRODUCTION : Objectives
- MATERIALS AND METHODS : Test formulations - Clinical study design - Porphyrins
Non-inflammatory lesions
Skin microbiome sampling
16S rRNA gene sequencing and predicted metagenomics
Data filtering and analysis
Facial colour mapping
RESULTS
Relative abundance and diversity
Reference frames and differential ranking
Porphyrins and non-inflammatory lesions assessment
- Table 1 : Formulations used in the clinical study
- Table 2 : Songbird output values for pathways related to N-acetylneuraminate degradation, mandelate degradation, hexitol degradation and tryptophan degradation |
| DOI : |
https://doi.org/10.1111/ics.12777 |
| En ligne : |
https://drive.google.com/file/d/1O4avryVbmE2KCmKDwKdGIKdskdHRNMHU/view?usp=shari [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=38144 |
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 44, N° 4 (08/2022) . - p. 440-452
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