Energizing the skin with phytoglycogen / Julia Baumann in GLOBAL PERSONAL CARE, Vol. 25, N° 1 (01/2024)  

[article]  inGLOBAL PERSONAL CARE > Vol. 25, N° 1 (01/2024) . - p. 36-39 Titre : Energizing the skin with phytoglycogen Type de document : texte imprimé Auteurs : Julia Baumann, Auteur ; Franziska Wandrey, Auteur ; Fred Zülli, Auteur Année de publication : 2024 Article en page(s) : p. 36-39 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge:Antirides Chimie végétale Dermo-cosmétologie Glycogène Le glycogène est un glucide complexe polymère du glucose. Il consiste en une chaîne de glucose lié en α (1-4) et est branché en α (1-6) tous les 8 ou 12 résidus. Il est utilisé par les animaux (et les champignons) pour stocker de l'énergie chimique et permet de libérer rapidement du glucose (principalement dans le foie et dans les cellules musculaires) au même titre que l'amidon chez les végétaux. Maïs et constituants Peau -- Soins et hygiène Phytocosmétiques Visage -- Soins et hygiène Index. décimale : 668.5 Parfums et cosmétiques Résumé : Skin cells are continuously exposed to environmental stresses, which makes them greatly reliant on large amounts of energy to combat cellular – and consequently skin – damage. As we age, cellular energy levels decline and the deficiencies in skin energy can result in premature skin ageing. By providing glycogen, the cells are given energy to use whenever it is needed and wherever it is needed, resulting in many beneficial effects for the skin. However, glycogen is usually isolated from animal sources. In this article a new plant-based glycogen is described, isolated from a special non-GMO sweetcorn, which is chemically identical to glycogen stored in animal cells. In vitro, the phytoglycogen was able to stimulate ATP production and cell metabolism, resulting in increased hyaluronic acid and collagen production. Clinically the topical application of the phytoglycogen provided fast and longlasting hydration effects, led to antiageing benefits and boosted the effects of hyaluronic acid. In summary, the safe and natural phytoglycogen is a multi-purpose cosmetic active, yielding excellent benefits for the skin. Note de contenu : - Glycogen : Densely packed energy for skin rejuvenation - A natural and safe plant-based glycogen to energize the skin - Methods : Cell culture and treatment - Quantification of intracellular ATP - HA and collagen I content - Clinical studies - Fig. 1 : Skin cells, energy and metabolism - Fig. 2 : Plant-based glycogen : structure and skin benefits En ligne : https://drive.google.com/file/d/1MsTA-MeRssu7govp3IEqTN-cuCVE7CYS/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=40633 [article]

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A novel Ca2+ double cone vector system to treat compromised skin / Julia Baumann in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 46, N° 2 (04/2024)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 46, N° 2 (04/2024) . - p. 228-238 Titre : A novel Ca2+ double cone vector system to treat compromised skin Type de document : texte imprimé Auteurs : Julia Baumann, Auteur ; Franziska Wandrey, Auteur ; Riikka Sacher, Auteur ; Fred Zülli, Auteur Année de publication : 2024 Article en page(s) : p. 228-238 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Barrière cutanée Dermo-cosmétologie Dermo-pharmacie Ions calcium Justification de l'allégation Peau -- Soins et hygiène Pénétration cutanée Systèmes de livraison (pharmacie) Vectorisation Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Background : Stressed, damaged or very aged skin is predominantly characterized by a malfunctioning skin barrier. Underlying skin barrier malfunction is a reduced or defective calcium gradient in the epidermis. Consequently, replenishing the compromised skin's calcium stores with topical calcium could be a potential therapeutic approach. - Methods : We investigated the effect of our novel Ca2+ double cone vector system on improving the differentiation and barrier function of reconstructed human epidermis (RHE), cultured at low basal calcium (0.3 mM) to represent very aged skin. Furthermore, in a randomized placebo-controlled clinical study the skin barrier of 20 healthy volunteers was challenged with 2% sodium lauryl sulphate (SLS) for 24 h under occlusion, following and/or prior to treatment with a gel containing 2% of our calcium vector system. - Results : Culture in reduced basal calcium conditions (0.3 mM) strongly impeded the formation of a dense stratified epidermis. The apical treatment with 1.1 mM CaCl2 was not able to restore a functional differentiation. Treatment with 0.1% of the Ca2+ delivery system rescued the differentiation process and resulted in a normal stratified epidermis. Clinically, application of the Ca2+ vector system prior to and following SLS stress prevented increases in skin irritation and transepidermal water loss (TEWL) compared to placebo controls. Importantly, the treatment also significantly accelerated the recovery time following SLS stress. - Conclusion : With our novel Ca2+ vector system, we highlight the delivery of bioavailable Ca2+ ions into the skin as a new and successful approach to treat a damaged barrier present in stressed, aged or atopic skin. Note de contenu : - Materials - Preparation of the Ca2+ double cone vector system - Freeze-fracture transmission electron microscopy - RHE culture and treatment - Skin explant treatment - Histology and immunohistochemistry - Clinical study - Statistical analysis DOI : https://doi.org/10.1111/ics.12926 En ligne : https://drive.google.com/file/d/1kR-2OF76x2qJYxVded6VP9A2YofW6QGP/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=40909 [article]

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A novel strategy for holistic skin rejuvenation / Julia Baumann in SOFW JOURNAL, Vol. 148, N° 10 (10/2022)  

[article]  inSOFW JOURNAL > Vol. 148, N° 10 (10/2022) . - p. 28-32 Titre : A novel strategy for holistic skin rejuvenation Type de document : texte imprimé Auteurs : Julia Baumann, Auteur ; Franziska Wandrey, Auteur ; Fred Zülli, Auteur Année de publication : 2022 Article en page(s) : p. 28-32 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge Biomolécules actives Cellules souches Dermo-cosmétologie Extraits de plantes:Extraits (pharmacie) Peau -- Soins et hygiène Rhododendron ferrugineum et constituants Sénolyse Index. décimale : 668.5 Parfums et cosmétiques Résumé : A revolutionary anti-aging concept, senolytics, has entered the medical world. Demonstrating remarkable results in early trials, senolytics can provoke rejuvenation in various tissues by specifically eliminating senescent cells without harming healthy cells. This concept has now been adapted for the cosmetic industry, by targeting and eliminating senescent fibroblasts in aged and photo-aged skin. To optimally complete skin rejuvenation however, the eliminated fibroblasts must be replaced with new cells - a feat that can be achieved by the activation of dermal stem cells. This revolutionary idea has been realized with the innovative ingredient concept SenoCellTecTM. Note de contenu : - MATERIALS AND METHODS : Senolytic assay - Dermal - epidermal communication in a full thickness skin model - Clinical study : effects of alipine rose leaf extract on skin redness - RESULTS AND DISUSSION : A novel senolytic active from Swiss alpine rose leaves - Holistic rejuvenation treatment : activating dermal progenitor cells - Clinically proven efficacy of the natural plant extracts En ligne : https://drive.google.com/file/d/1tRfffLTR5L7eo7o6V1MzjxLg8xAvRBar/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=38246 [article]

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Restoring skin with a novel Ca2+ delivery system / Julia Baumann in GLOBAL PERSONAL CARE, Vol. 23, N° 9 (10/2022)  

[article]  inGLOBAL PERSONAL CARE > Vol. 23, N° 9 (10/2022) . - p. 29-32 Titre : Restoring skin with a novel Ca2+ delivery system Type de document : texte imprimé Auteurs : Julia Baumann, Auteur ; Franziska Wandrey, Auteur ; Fred Zülli, Auteur Année de publication : 2022 Article en page(s) : p. 29-32 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Barrière cutanée Calcium Dermo-cosmétologie Peau -- Soins et hygiène Régénération (biologie) Index. décimale : 668.5 Parfums et cosmétiques Résumé : Ageing and metabolic disorders such as diabetes are key drivers that can lead to skin barrier disruption. Despite the increasing demand for cosmetic treatments for old/diabetic skin, current options are limited and often include occlusive formulations. A major characteristic of a disrupted skin barrier is a defective calcium gradient in the epidermis. Therefore, replenishing the aged/diabetic skin’s calcium stores with topical calcium could be a potential therapeutic approach. Both in vitro and clinical studies have shown, that a novel calcium ion (Ca2+) vector system enables the successful delivery of bioavailable Ca2+ ions into the skin, aiding not only in recovery but also in protection of the skin from SLS stress. This highlights the use of this vector system as a new and superior approach to treat a damaged barrier present in diabetic, aged, or atopic skin. Note de contenu : - The epidermal calcium gradient underlies skin health - Replenish the skin's calcium stores with bioavailable Ca2+ - Methods : Preparation of the Ca2° double cone carrier system - RHE culture and treatment - Skin explant treatment - Clinical study En ligne : https://drive.google.com/file/d/1oFixv4w4hcbcbLw3G3e1WTSMil4Tax_M/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=38659 [article]

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Senolytics : Eliminating senescent cells / Julia Baumann in GLOBAL PERSONAL CARE, Vol. 23, N° 1 (01/2022)  

[article]  inGLOBAL PERSONAL CARE > Vol. 23, N° 1 (01/2022) . - p. 35-37 Titre : Senolytics : Eliminating senescent cells Type de document : texte imprimé Auteurs : Julia Baumann, Auteur ; Franziska Wandrey, Auteur ; Fred Zülli, Auteur Année de publication : 2022 Article en page(s) : p. 35-37 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Anti-inflammatoires Cuir chevelu -- Soins et hygiène Dermo-cosmétologie Extraits de plantes:Extraits (pharmacie) Sénolyse Index. décimale : 668.5 Parfums et cosmétiques Résumé : Cellular senescence, a condition of irreversible cell cycle arrest, can lead to inflammation and accelerated ageing of tissues, including the skin. To prevent this, current strategies aim specifically to eliminate the senescent cells, or ‘zombie cells’, by means of senolytics. Sensitive scalps are a prominent problem and one potential treatment option is the use of senolytics in scalp care. As with the skin, zombie cells in the scalp can cause local inflammation, leading to dry and irritated scalps, so clearing these cells could promote a healthy scalp. An extract from the leaves of the Swiss Alpine rose was found to have strong senolytic activity in fibroblasts. In a placebo-controlled clinical study, the extract further demonstrated a significant soothing effect on sensitive scalps. This study firstly highlights the positive impact of senolytics in scalp health and care. Note de contenu : - Nature' senolytic - Sensitive scalps : A common problem - Methods - Results a discussion - Scalp redness & itching En ligne : https://drive.google.com/file/d/1Fc4-mpR4S9dqy4i40gj4q0-vwYFPEzU_/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=37087 [article]

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