| Titre : |
Fabrication and characterization of electrospun thermoplastic polyurethane/fibroin small-diameter vascular grafts for vascular tissue engineering |
| Type de document : |
texte imprimé |
| Auteurs : |
E. Yu, Auteur ; J. Zhang, Auteur ; J. A. Thomson, Auteur ; Lih-Sheng Turng, Auteur |
| Année de publication : |
2016 |
| Article en page(s) : |
p. 638-646 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Cellules -- Cultures et milieux de culture
Electrofilature
Fourier, Spectroscopie infrarouge à transformée de
Ingénierie tissulaire
Polymères en chirurgie
Polymères en médecine
Polyuréthanes
Protéines végétales
Prothèses
Prothèses vasculaires
Soie et constituants
Technologie médicale
Textiles et tissus à usages médicaux
Textiles et tissus à usages techniques
Textiles et tissus à usages techniques -- Propriétés mécaniques
|
| Index. décimale : |
668.4 Plastiques, vinyles |
| Résumé : |
The demand for small-diameter blood vessel substitutes has been increasing due to a shortage of autograft vessels and problems with thrombosis and intimal hyperplasia with synthetic grafts. In this study, hybrid small-diameter vascular grafts made of thermoplastic polyurethane (TPU) and silk fibroin, which possessed a hybrid fibrous structure of an aligned inner layer and a random outer layer, were fabricated by the electrospinning technique using a customized striated collector that generated both aligned and random fibers simultaneously. A methanol post-treatment process induced the transition of fibroin protein conformation from the water-soluble, amorphous, and less ordered structures to the water-insoluble ?-sheet structures that possessed robust mechanical properties and relatively slow proteolytic degradation. The methanol post-treatment also created crimped fibers that mimicked the wavy structure of collagen fibers in natural blood vessels. Ultrafine nanofibers and nanowebs were found on the electrospun TPU/fibroin samples, which effectively increased the surface area for cell adhesion and migration. Cyclic circumferential tensile test results showed compatible mechanical properties for grafts made of a soft TPU/fibroin blend compared to human coronary arteries. In addition, cell culture tests with endothelial cells after 6 and 60 days of culture exhibited high cell viability and good biocompatibility of TPU/fibroin grafts, suggesting the potential of applying electrospun TPU/fibroin grafts in vascular tissue engineering. |
| Note de contenu : |
- CELL CULTURE AND SEEDING
- RESULTS AND DISCUSSION : Fourier transform infrared spectroscopy - Structure and morphology - Mechanical properties - Cell culture results |
| DOI : |
10.3139/217.3247 |
| En ligne : |
https://drive.google.com/file/d/194seUjb8XJD2n49MLWsSuLnGz-z9Vk8L/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=27401 |
in INTERNATIONAL POLYMER PROCESSING > Vol. XXXI, N° 5 (11/2016) . - p. 638-646
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