Coenzyme Q10 has anti-aging effects on human hair / Melanie Giesen in IFSCC MAGAZINE, Vol. 11, N° 1 (01-02-03/2008)

[article]  inIFSCC MAGAZINE > Vol. 11, N° 1 (01-02-03/2008) . - p. 37-42 Titre : Coenzyme Q10 has anti-aging effects on human hair Type de document : texte imprimé Auteurs : Melanie Giesen, Auteur ; Thomas Welß, Auteur ; Erik Schulze zur Wiesche, Auteur ; Volker Scheunemann, Auteur ; Sabine Gruedl, Auteur ; Yasmin Oezkabakcioiglu, Auteur ; Elisabeth Poppe, Auteur ; Dirk Petersohn, Auteur Année de publication : 2008 Article en page(s) : p. 37-42 Note générale : Bibliogr. Langues : Anglais (eng) Tags : 'Coenzyme  Q10'  'Follicule  de  cheveux'  Vieillissement  'Kératinocytes  externes  la  gaine  racine'  'Synthèse  kératine' Index. décimale : 668.5 Parfums et cosmétiques Résumé : Ubiquinones are the most widespread and therefore best investigated bioquinones. Due to their hydrophobic isoprenoid side chain, ubiquinones can be solubilized in organic solvents or lipids but are insoluble in water. Using a specific emulsifier system it has been possible to deliver positive effects to biological systems also from aqueous formulations. Ubiquinone-50, also referred to as coenzyme Q10, is well known in cosmetic science and especially in skin care because of its antioxidant activity. It is found in the membranes of peroxisomes, lysosomes, vesicles, the endoplasmic reticulum and notably in the inner membrane of the mitochondrion, where it is an important part of the electron transport chain. Using coenzyme Q10 in the proposed emulsifier system we could show that the molecule not only has relevance as an anti-aging bioactive in skin care but also has positive effects on the human hair follicle. The hair follicle is a complex mini organ and synthesis of hair keratin, the major component of hair fibers, is an essential prerequisite for the growth of strong and healthy hair. But like all biological systems the hair follicle, the biologically active part of the hair, also undergoes an aging process associated among other things with a decline in certain hair keratins. Due to this age-related shift in basic structural proteins of the hair shaft, mature hair often becomes fragile and difficult to manage. Therefore it is a challenge for cosmetic science to provide bioactives to fight age-related changes and maintain a youthful appearance of hair. Using cultivated hair follicle keratinocytes we identified coenzyme Q10 as a potent bioactive that stimulates the gene expression of different hair keratins, especially those which are reduced during aging processes in hair follicles. These results led us to investigate a shampoo and a tonic formulation enriched with coenzyme Q10 in a placebo-controlled panel study. In a left/right comparison a group of healthy volunteers older than 40 years of age applied the formulations daily for 4 days. Throughout the test period the gene expression of different hair keratins from plucked hair follicles was determined using quantitative polymerase chain reaction techniques. Subsequent statistical analysis revealed an increase in age-relevant hair keratins in human hair roots treated with coenzyme Q10, thus pointing out the striking benefits of coenzyme Q10 in hair care formulations. We conclude that coenzyme Q10 is an ideal ingredient for hair care formulations, providing anti-aging properties through activation of specific keratins aligned with the needs of mature hair. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10387 [article]

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Cutaneous restructuration by apple seed phytosterols : from DNA chip analysis to morphological alteration / Thomas Doering in IFSCC MAGAZINE, Vol. 7, N° 4 (10-11-12/2004)

[article]  inIFSCC MAGAZINE > Vol. 7, N° 4 (10-11-12/2004) Titre : Cutaneous restructuration by apple seed phytosterols : from DNA chip analysis to morphological alteration Type de document : texte imprimé Auteurs : Thomas Doering, Auteur ; Olaf Holtkötter, Auteur ; Kordula Schlotmann, Auteur ; Claudia Jassoy, Auteur ; Dirk Petersohn, Auteur ; Armin Wadle, Auteur ; Marianne Waldmann-Laue, Auteur Année de publication : 2004 Note générale : Bibliogr. Langues : Anglais (eng) Tags : 'Skin  equivalent'  'cDNA  microarray'  'hyaluronic  acid'  phytosterols  'anti-wrinkle'  'skin  elasticity' Index. décimale : 668.5 Parfums et cosmétiques Résumé : Plant secondary metabolites such as flavonoids, isoflavones and phytosterols have been proposed as cosmetic ingredients displaying anti-aging effects. On the cellular level, however, the activity profiles of these ingredients are only partially understood. In this study we analyzed the effects of apple seed phytosterols on age-related structural and functional parameters using cell biochemical, molecular biological and bioengineering techniques. The expression of age-related genes was studied using skin equivalents and cDNA microarrays. Incubation of skin equivalents with apple seed phytosterols had significant consequences: (i) differential regulation of a set of genes associated with keratinocyte proliferation and differentiation, (ii) stimulation of hyaluronic acid synthesis, and (iii) increase of epidermal thickness. In vivo studies revealed that apple seed phytosterols improve skin elasticity and decrease skin roughness. In conclusion, apple seed phytosterols display distinct biological effects and significantly improve the structure and function of mature skin. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10481 [article]

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Synergistic effects of taurine and caffeine on regulation of the hair cycle : composition of bioactives against premature hair loss / Thomas Welss in IFSCC MAGAZINE, Vol. 15, N° 2 (04-05-06/2012)

[article]  inIFSCC MAGAZINE > Vol. 15, N° 2 (04-05-06/2012) . - p. 81-87 Titre : Synergistic effects of taurine and caffeine on regulation of the hair cycle : composition of bioactives against premature hair loss Type de document : texte imprimé Auteurs : Thomas Welss, Auteur ; Melanie Giesen, Auteur ; Thorsten Knappe, Auteur ; Melanie Briese, Auteur ; Philipp Spuhler, Auteur ; Dirk Petersohn, Auteur ; Thomas Förster, Auteur Année de publication : 2012 Article en page(s) : p. 81-87 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Alopécie Caféine Cheveux -- Soins et hygiène Cuir chevelu -- Soins et hygiène Produits capillaires Taurine Index. décimale : 668.5 Parfums et cosmétiques Résumé : Hair is an attribute of health, youth and attractiveness. Therefore, premature hair loss often is indicative for the well-being of the affected persons. The focus of this study was to identify bioactive substances which counteract premature hair loss by targeted support of the anagen phase of the hair cycle. Therefore, we implemented a test strategy comprising a novel three-dimensional organotypic tissue model of the human dermal papilla for in vitro screening purpose and a noninvasive method to validate the effects in vivo. In the screening approach physiological changes after stimulation with caffeine, taurine or combinations of both were described by analyzing the gene expression of typical anagen and catagen markers (HGF and GFBP-3) as well as the release of the anagen associated growth factor HGF. These results revealed synergistic effects of caffeine and taurine in terms of anagen-stimulatory processes assuming an elongation of the anagen phase. This was additionally supported by analyzing changes in the molecular profiles of anagen-associated HGF protein release and catagen-associated IGFBP-3 gene expression in the plucked hair follicle in vivo after using products containing the active combination. Both methods support the assumption that combination of caffeine and taurine in a hair care composition positively influences hair growth and reduces premature hair loss. Note de contenu : - EXPERIMENTAL : Preparation of the reconstructed human dermal papilla - Formulation assisting software toolkit (FAST) - Cytotoxicity in vitro - Differential gene expression - Protein analysis - RESULTS : Design of experiment - Analysis of cytotoxicity - Analysis of differential gene expression in vitro - Protein analysis in vitro - Evaluation of molecular profile in vivo Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=14956 [article]

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