Titre : |
The benefits of skin lipidomics |
Type de document : |
texte imprimé |
Auteurs : |
Oliver Uecke, Auteur |
Année de publication : |
2017 |
Article en page(s) : |
p. 62-63 |
Langues : |
Anglais (eng) |
Catégories : |
Chimie analytique Dermatologie Lipides Peau -- analyse Spectrométrie de masse
|
Index. décimale : |
668.5 Parfums et cosmétiques |
Résumé : |
The lipid composition of human skin is essential for its function. However, the simultaneous quantification of a wide range of stratum corneum and sebaceous lipids is not trivial. We developed and validated a quantitative high-throughput shotgun mass spectrometry-based platform for lipid analysis of tape-stripped skin samples. Lipotype analyses also other types of skin samples, from monolayers to 3D models. It is now easy to investigate how the healthy skin lipidome is composed, how it changes in diseases or upon intervention with a drug or a cosmetic product. This lipidomic data can be used for cosmetic claim support, topical drug development and personalised cosmetics. More details about this method and its application can be found in: Sadowskii T. et al. 'Large-scale human skin lipidomics by quantitative, high-throughput shotgun mass spectrometry' Scientific Report 2017, doi: 10.1038/srep43761 |
Note de contenu : |
- Ultra-broad coverage
- Easy sampling
- Absolute quantification
- Reproducible results
- Full high-throughput
- Individual skin lipid profiles
- Advantages of lipidomics
- Table : Lipid classes covered by our method in skin samples
- FIGURES : 1. Tape sampling is comparable with scrape-biopsy - 2. Lipids are quantifiable in wide ranges - 3. Measurements are highly reproducible - 4. Various body spots have different lipid composition - 5. Skin lipid composition changes with age |
En ligne : |
https://drive.google.com/file/d/1rfosDp-xGRtqK1cOkzxH8lKrDGl-shpD/view?usp=drive [...] |
Format de la ressource électronique : |
Pdf |
Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=29382 |
in PERSONAL CARE EUROPE > Vol. 11, N° 5 (11/2017) . - p. 62-63