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Titre : The benefits of skin lipidomics Type de document : texte imprimé Auteurs : Oliver Uecke, Auteur Année de publication : 2017 Article en page(s) : p. 62-63 Langues : Anglais (eng) Catégories : Chimie analytique
Dermatologie
Lipides
Peau -- analyse
Spectrométrie de masseIndex. décimale : 668.5 Parfums et cosmétiques Résumé : The lipid composition of human skin is essential for its function. However, the simultaneous quantification of a wide range of stratum corneum and sebaceous lipids is not trivial. We developed and validated a quantitative high-throughput shotgun mass spectrometry-based platform for lipid analysis of tape-stripped skin samples. Lipotype analyses also other types of skin samples, from monolayers to 3D models. It is now easy to investigate how the healthy skin lipidome is composed, how it changes in diseases or upon intervention with a drug or a cosmetic product. This lipidomic data can be used for cosmetic claim support, topical drug development and personalised cosmetics. More details about this method and its application can be found in: Sadowskii T. et al. 'Large-scale human skin lipidomics by quantitative, high-throughput shotgun mass spectrometry' Scientific Report 2017, doi: 10.1038/srep43761 Note de contenu : - Ultra-broad coverage
- Easy sampling
- Absolute quantification
- Reproducible results
- Full high-throughput
- Individual skin lipid profiles
- Advantages of lipidomics
- Table : Lipid classes covered by our method in skin samples
- FIGURES : 1. Tape sampling is comparable with scrape-biopsy - 2. Lipids are quantifiable in wide ranges - 3. Measurements are highly reproducible - 4. Various body spots have different lipid composition - 5. Skin lipid composition changes with ageEn ligne : https://drive.google.com/file/d/1rfosDp-xGRtqK1cOkzxH8lKrDGl-shpD/view?usp=drive [...] Format de la ressource électronique : Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=29382
in PERSONAL CARE EUROPE > Vol. 11, N° 5 (11/2017) . - p. 62-63[article]Réservation
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