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Production of the tissue inhibitor of metalloproteinase-2 (TIMP-2) and evaluation of its potential as anti-aging active / Rolf Schütz in IFSCC MAGAZINE, Vol. 8, N° 3 (07-08-09/2005)
[article]
Titre : Production of the tissue inhibitor of metalloproteinase-2 (TIMP-2) and evaluation of its potential as anti-aging active Type de document : texte imprimé Auteurs : Rolf Schütz, Auteur ; Beatrice König, Auteur ; Beat Hochtrasser, Auteur ; Patrick Stolz, Auteur ; Dominik Imfeld, Auteur Année de publication : 2005 Article en page(s) : p. 171-177 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge
Biomolécules activesTags : 'Matrice métalloprotéinases' TIMP 'Expression de la protéine recombinante' du collagène' Ingrédient cosmétique' Index. décimale : 668.5 Parfums et cosmétiques Résumé : Collagen-degrading matrix metalloproteinases (MMPs) show increased activities predominantly in UV-irradiated skin as well as in chronologically aged skin. MMPs are therefore reasoned to be associated with the degenerative alterations in the collagenous dermal extracellular matrix, which in turn may accelerate the signs of skin aging such as wrinkle formation and skin sagging. In normal physiological processes MMP activity is controlled by the endogenous tissue inhibitors of metalloproteinases (TIMPs). Here we report the biotechnological production of the human-identical inhibitor TIMP-2 and its evaluation as an anti-aging active through attenuation of the degenerative MMP activity. The recombinant TIMP-2 polypeptide selectively inhibited MMPs in vitro which are involved in aging processes and showed efficient IC50 values in the low nanomolar range. Topical application of formulated TIMP-2 on skin explants with subsequent UVB irradiation (2-3 MED) resulted in an almost quantitative protection against collagen degradation. Thus, our biotechnological production of TIMP-2 leads to the active broad-spectrum MMP inhibitor that reduces excessive MMP activity and thereby preserves the structural integrity of collagen network. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10490
in IFSCC MAGAZINE > Vol. 8, N° 3 (07-08-09/2005) . - p. 171-177[article]Réservation
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Code-barres Cote Support Localisation Section Disponibilité 003888 - Périodique Bibliothèque principale Documentaires Disponible The effects of Areca Catechu L extract on anti-aging / Kun-Kook Lee in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 21, N° 4 (08/1999)
[article]
Titre : The effects of Areca Catechu L extract on anti-aging Type de document : texte imprimé Auteurs : Kun-Kook Lee, Auteur ; Jung-Do Choi, Auteur Année de publication : 1999 Article en page(s) : p. 285–295 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge
Cosmétiques
Peau -- Soins et hygièneTags : Elastase 'Anti-âge' 'Synthèse du collagène' 'Palmier à bétel' Inhibition Index. décimale : 668.5 Parfums et cosmétiques Résumé : The anti-aging effects of Areca catechu L extract (CC-516) on skin were investigate both in vitro and in vivo. The CC-516 has a high proportion of proline (13%) of free amino acid content. The inhibitory effect of CC-516 on the elastase exhibited 37 to 90% inhibition by 10 to 250 μg/ml concentration ; the IC values with 40.8 μg/ml for porcine pancreatic elastase (PPE) and 48.1 μg/ml for human leukocyte elastase (HLE), respectively. One of the effects of elastase is that it is known to reduce the number of elastin fibers at the level of the enzyme deposition. The number of elastin fibers was increased when we drift from the deposit number of elastase with 100 mg/ml of CC-516. CC-516 showed protection of elastic fiber against degradation by the enzyme in an ex vivo assay. The CC-516 increased proliferation of human fibroblast cell by 85% at 10 concentration, compared with control, whereas the increase by ascorbic acid was 50%. The collagen synthesis was increased by 40% at 10% concentration of CC-516. The treatment with CC-516 improved skin hydration, the skin elasticity, and skin wrinkles. From this study, we suggest that CC-516 can be used as a new anti-aging component for cosmetics. DOI : 10.1046/j.1467-2494.1999.196563.x En ligne : https://onlinelibrary.wiley.com/doi/10.1046/j.1467-2494.1999.196563.x Format de la ressource électronique : Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=26486
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 21, N° 4 (08/1999) . - p. 285–295[article]