Highly stable and fast-dissolving ascorbic acid-loaded microneedles / Jeerapond Leelawattanachai in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 45, N° 5 (10/2023)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 45, N° 5 (10/2023) . - p. 612-626 Titre : Highly stable and fast-dissolving ascorbic acid-loaded microneedles Type de document : texte imprimé Auteurs : Jeerapond Leelawattanachai, Auteur ; Kedsara Panyasu, Auteur ; Kornkanok Prasertsom, Auteur ; Supone Manakasettharn, Auteur ; Hathaiphat Duangdaw, Auteur ; Pitchaon Budthong, Auteur ; Naranya Thepphornbanchakit, Auteur ; Kullachate Muangnapoh, Auteur ; Sira Srinives, Auteur ; Dujduan Waraho-Zhmayev, Auteur ; Darapond Triampo, Auteur Année de publication : 2023 Article en page(s) : p. 612-626 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Dissolution (chimie) Formulation (génie chimique) -- Stabilité Micro-aiguilles Pénétration cutanée Polyéthylèneimine Systèmes de livraison (pharmacie) Tests de sécurité Vectorisation Vitamine C Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objectives : Ascorbic acid has many benefits to the skin. Numerous attempts to promote its topical delivery show great challenges since its chemical instability and poor skin impermeability. Microneedle delivery is a simple, safe, painless and effective means to deliver therapeutic or nourishing molecules into the skin. The purpose of this study was twofold : (a) to develop a new formulation of ascorbic acid-loaded microneedles to enhance ascorbic acid stability by investigating an optimal amount of polyethyleneimine as an additive to the dextran-based microneedle formulation and (b) to assess microneedle properties in terms of dissolving rate, skin penetration ability, biocompatibility and antimicrobial activity. - Methods : The microneedles formulated with ascorbic acid and varied polyethyleneimine concentrations were fabricated and subsequently tested for ascorbic acid stability using 2,2-diphenyl-1-picrylhydrazyl assay. The dissolution rate and skin penetration depth were investigated in porcine skin and the reconstructed human full-thickness skin model respectively. The skin irritation tests were done according to the Organisation for Economic Co-operation and Development Test Guideline No. 439. An antimicrobial disc susceptibility test was performed against Escherichia coli, Staphylococcus aureus and Staphylococcus epidermidis. - Results : Among varied amounts of 0%, 1.5%, 3.0% and 4.5% (w/v), the 3.0% polyethyleneimine showed the most desirable characteristics, including well-preserved shape integrity after demoulding, significantly improved stability of ascorbic acid (p < 0.001) from 33% to 96% antioxidant activity after 8 weeks of storage at 40°C, increased dissolving rate (p < 0.001) by being completely dissolved within 2 min after the skin insertion, passing skin penetration and biocompatibility tests as well as having a broad spectrum of antimicrobial property. - Conclusion : With a safety profile and enhanced properties, the new formulation of ascorbic acid-loaded microneedles shows outstanding potential as commercially available cosmetics and healthcare products. Note de contenu : - MATERIALS AND METHODS : Materials - Fabrication and characterization of AA-loaded dissolving microneedles - Stability test of AA-loaded microneedle after storage at various conditions - Fourier-transform infrared spectroscopy (FTIR) - Dissolution test of AA-loaded microneedles - In vitro skin permeation experiment with AA - Skin penetration experiment - Antimicrobial disc susceptibility test - Skin irritation test of AA-loaded microneedles - Statistical analysis - RESULTS AND DISCUSSION : Fabrication and characterization of AA-loaded microneedles - Stability test of AA-loaded microneedle after storage at various conditions - Dissolution test of AA-loaded microneedles - In vitro skin permeation experiment with AA - Skin penetration experiment - Antimicrobial disc susceptibility test - Skin irritation test of AA-loaded microneedles DOI : https://doi.org/10.1111/ics.12865 En ligne : https://drive.google.com/file/d/1A7uzPuS6f_fW_vYCVoxz74idDbVfUPQO/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=40088 [article]

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