Efficient dermal delivery of ascorbic acid 2-glucoside with photoacoustic waves / Sofia Melo-Guímaro in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 44, N° 4 (08/2022)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 44, N° 4 (08/2022) . - p. 453-463 Titre : Efficient dermal delivery of ascorbic acid 2-glucoside with photoacoustic waves Type de document : document électronique Auteurs : Sofia Melo-Guímaro, Auteur ; Renato Cardoso, Auteur ; Celso Paiva João, Auteur ; João Santos, Auteur ; Elodie Melro, Auteur ; Luis G. Arnaut, Auteur ; Jorge Costa Pereira, Auteur ; Carlos Serpa, Auteur Année de publication : 2022 Article en page(s) : p. 453-463 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge Barrière cutanée Dermo-cosmétologie Formulation (Génie chimique) Gels -- Emploi en cosmétologie Ondes photoacoustiques Pénétration cutanée Systèmes de livraison (pharmacie) Vitamine C Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Ascorbic acid (i.e., vitamin C) is an important antioxidant present in skin. The protective role of vitamin C against photoaging motivated numerous attempts to promote its topical delivery, with a success limited by its chemical instability and poor skin permeability. Vitamin C precursors, such as ascorbic acid 2-glucoside (AA2G), which are metabolized to vitamin C by enzymes present in the skin, solve the problem of stability but are limited by low skin permeability. We developed a 2% (w/v) gel formulation of AA2G application (viscosity 4.30 × 104 Pa.s, pH 5.94) and compared its passive dermal delivery with the delivery promoted by photoacoustic waves that transiently perturb the skin barrier. - Methods : Photoacoustic (PA) waves were generated by laser pulses absorbed by piezophotonic (light-to-pressure) transducers. Pig skin samples were exposed to the 2% AA2G formulation alone or combined with 5 min of PA waves. One hour later, AA2G was extracted from the skin and quantified by reverse-phase HPLC. AA2G transdermal fluxes using Franz cells with 760 μm thick pig skin samples were also measured. - Results : Photoacoustic waves transiently enhanced skin permeability and increased dermal delivery of AA2G. AA2G was released from the formulation nearly quantitatively (92.6 ± 6.2%) in 24 h, showing a non-Fickian behaviour controlled by diffusion and swelling. AA2G dermal delivery with exposure for 5 min to PA waves was compared with passive delivery to pig skin. PA waves increased the delivery of AA2G to the skin by a factor of 15-fold with respect to passive delivery, as measured from skin extracts after 1 h of contact of the formulation with the skin. - Conclusion : Five minutes of exposure to PA waves is a safe and effective method to deliver large quantities of AA2G to the skin. Note de contenu : - MATERIALS AND METHODS : Materials - Characterization of photoacoustic waves - Skin samples preparation - Preparation of ascorbic acid 2-glucoside gel formulation - In vitro release of ascorbic acid 2-glucoside - In vitro transdermal delivery of ascorbic acid 2-glucoside - HPLC analytical methods - Data analysis - Statistical analysis - RESULTS AND DISCUSSION : In vitro release of ascorbic acid 2-glucoside - In vitro dermal delivery of ascorbic acid 2-glucoside - Table 1 : High-performance liquid chromatography elution protocol for the quantitative analysis of the transdermal delivery in vitro experiments samples - Table 2 : Summary of the AA2G release data fit using mathematical models - Table 3 : Amount of AA2G extracted from skin samples after 12h and 1h of contact with the formulation DOI : https://doi.org/10.1111/ics.12793 En ligne : https://drive.google.com/file/d/1p9GpgZCE40JSS3624kii6ujQnuogcMdV/view?usp=shari [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=38145 [article]

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