| Titre : |
Sebum regulation activity of mangifera indica for multiple skin ethnicities : A biological evaluation |
| Type de document : |
texte imprimé |
| Auteurs : |
Chloé Boira, Auteur ; Morgane de Tollenaere, Auteur ; Emilie Chapuis, Auteur ; Laura Lapierre, Auteur ; Bénédicte Sennelier-Portet, Auteur ; Jessy Martinez, Auteur ; Amandine Scandolera, Auteur ; Romain Reynaud, Auteur |
| Année de publication : |
2022 |
| Article en page(s) : |
p. 16-20 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Acné L'acné (nom féminin) est une dermatose (maladie de la peau) inflammatoire des follicules pilosébacés (glandes sécrétant le sébum, à la racine des poils) avec formation de comédons.
Cette maladie de la peau est représentée dans sa forme la plus fréquente par l'acné polymorphe juvénile qui touche les adolescents, mais qui ne résume pas toutes les acnés. Il existe aussi des acnés exogènes d'origine professionnelle, médicamenteuse, cosmétique...
Cosmétiques
Dermo-cosmétologie
Extraits de plantes:Extraits (pharmacie)
Lipogénèse
Peau -- Soins et hygiène
Séborrhée
Sécrétion -- Régulation
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Oily skin is one of the most common issue in the cosmetic field and concern both teenagers and adults from all ethnicities. Unfortunately, the current irritating treatments lead to skin dryness, sebaceous gland atrophy and impact the skin barrier integrity. The aim of this study was to evaluate Mangifera indica extract as a new way to solve oily condition for Caucasian, African and Asian skins. Mangifera indica significantly reduced the production of lipids on various ethnicities on human sebocytes derived from iPS. Transcriptomic analysis on all ethnicities of several genes involved in sebum production has demonstrated that Mangifera indica significantly regulated lipogenesis on iPS-derived-human sebocytes. Ex vivo studies confirmed that Mangifera indica played on lipogenesis inhibition without impacting integrity of sebaceous glands. Finally, we confirmed at the clinical level a significant reduction of sebum production on Caucasian, Asian and African skins. Our results showed that Mangifera indica is an inclusive seboregulator, efficient on the three major ethnicities through an innovative mode of action controlling lipogenesis without impacting sebaceous gland morphology. Considering that sebum overproduction is related to acne concern, our results support a role for Mangifera indica in the therapeutic strategy for prevention and treatment of acne. |
| Note de contenu : |
- MATERIALS & METHODS : In vitro lipogenesis inhibition in sebocytes derived from iPS - Identification of the mode of action by qPCR - Ex vivo sebum release inhibition in sebaceous gland - Clinical investigation - Statistical analysis
- RESULTS : Inhibition of sebum production on human sebocytes IPS from caucasian, asian and african origins - Elucidation of mode of action related to sebo-regulation property - Sebaceous gland volume reduction analysis - Integrity of the sebaceous glands - Impact of mangifera indica at 1% on caucasian volunteers - Impact of mangifera indica at 2% on asian volunteers - Impact of mangifera indica at 2% on african volunteers |
| En ligne : |
https://drive.google.com/file/d/11wyw3RvpVLSJmR0EuwnEOnBcZACZfyCi/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=38058 |
in SOFW JOURNAL > Vol. 148, N° 9 (09/2022) . - p. 16-20
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