| Titre : |
A novel Ca2+ double cone vector system to treat compromised skin |
| Type de document : |
texte imprimé |
| Auteurs : |
Julia Baumann, Auteur ; Franziska Wandrey, Auteur ; Riikka Sacher, Auteur ; Fred Zülli, Auteur |
| Année de publication : |
2024 |
| Article en page(s) : |
p. 228-238 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Barrière cutanée
Dermo-cosmétologie
Dermo-pharmacie
Ions calcium
Justification de l'allégation
Peau -- Soins et hygiène
Pénétration cutanée
Systèmes de livraison (pharmacie)
Vectorisation
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
- Background : Stressed, damaged or very aged skin is predominantly characterized by a malfunctioning skin barrier. Underlying skin barrier malfunction is a reduced or defective calcium gradient in the epidermis. Consequently, replenishing the compromised skin's calcium stores with topical calcium could be a potential therapeutic approach.
- Methods : We investigated the effect of our novel Ca2+ double cone vector system on improving the differentiation and barrier function of reconstructed human epidermis (RHE), cultured at low basal calcium (0.3 mM) to represent very aged skin. Furthermore, in a randomized placebo-controlled clinical study the skin barrier of 20 healthy volunteers was challenged with 2% sodium lauryl sulphate (SLS) for 24 h under occlusion, following and/or prior to treatment with a gel containing 2% of our calcium vector system.
- Results : Culture in reduced basal calcium conditions (0.3 mM) strongly impeded the formation of a dense stratified epidermis. The apical treatment with 1.1 mM CaCl2 was not able to restore a functional differentiation. Treatment with 0.1% of the Ca2+ delivery system rescued the differentiation process and resulted in a normal stratified epidermis. Clinically, application of the Ca2+ vector system prior to and following SLS stress prevented increases in skin irritation and transepidermal water loss (TEWL) compared to placebo controls. Importantly, the treatment also significantly accelerated the recovery time following SLS stress.
- Conclusion : With our novel Ca2+ vector system, we highlight the delivery of bioavailable Ca2+ ions into the skin as a new and successful approach to treat a damaged barrier present in stressed, aged or atopic skin. |
| Note de contenu : |
- Materials
- Preparation of the Ca2+ double cone vector system
- Freeze-fracture transmission electron microscopy
- RHE culture and treatment
- Skin explant treatment
- Histology and immunohistochemistry
- Clinical study
- Statistical analysis |
| DOI : |
https://doi.org/10.1111/ics.12926 |
| En ligne : |
https://drive.google.com/file/d/1kR-2OF76x2qJYxVded6VP9A2YofW6QGP/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=40909 |
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 46, N° 2 (04/2024) . - p. 228-238
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A novel Ca2+ double cone vector system to treat compromised skin in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 46, N° 2 (04/2024)
