| Titre : |
The effect of Salix alba L. bark extract on dark circles in vitro and in vivo |
| Type de document : |
texte imprimé |
| Auteurs : |
Suwon Jeon, Auteur ; Sohyun Yoon, Auteur ; Yuna Kim, Auteur ; Seoungwoo Shin, Auteur ; Hyanggi Ji, Auteur ; Eunae Cho, Auteur ; Deokhoon Park, Auteur ; Eunsun Jung, Auteur |
| Année de publication : |
2023 |
| Article en page(s) : |
p. 636-646 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Barrière cutanée
Cellules -- Cultures et milieux de culture
Cernes
Cosmétiques
Dermo-cosmétologie
Extraits de plantes:Extraits (pharmacie)
Formulation (Génie chimique)
Ongle -- Anatomie
Peau -- Physiologie
Peau -- Soins et hygiène
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
- Objective : Dark circles in the infraorbital area are a common cosmetic concern among individuals because they exhibit fatigue and are undesirable across all ages. Of the dark circle etiologies, blood stasis by poor-vascular integrity can cause darkening of the lower eyelid skin, which might be alleviated by reduced endothelial permeability. In this study, we investigated the effects of Salix alba bark extract (SABE) on the synthesis of hyaluronic acid (HA) in fibroblasts and vascular integrity protection from inflammatory cytokine. We also performed a clinical trial investigating the effect of SABE on dark circles.
- Methods : To confirm the effect of SABE on HA synthesis in human dermal fibroblasts (HDFs), we performed ELISA and real-time PCR. We investigated the interaction HDF-secreted substance with vascular integrity, and human dermal microvascular endothelial cells (HMEC-1) were treated with conditioned medium (CM) from HDF treated with or without SABE. Subsequently, we conducted a clinical study on 29 subjects by having them apply SABE containing cream for 8 weeks.
- Results : Salix alba bark extract treatment increased HA synthesis and regulated HMW–HA-related gene expressions in HDF. CM from SABE-treated HDF alleviated endothelial permeability and led to improved vascular integrity in HMEC-1 cells. Treatment with the cream containing 2% SABE for 8 weeks improved the parameters measuring dark circles, skin microcirculation and elasticity.
- Conclusion : Our results showed that SABE could protect against dark circles in vitro, and that topical treatment of SABE improved the clinical indexes of dark circles in a clinical study. Therefore, SABE can be used as an active ingredient for improving dark circles. |
| Note de contenu : |
- MATERIALS AND METHODS : Preparation of Salix alba bark extract (SABE) - Cell culture and reagent - Hyaluronic acid enzyme-linked immunosorbent assay (ELISA) - RNA preparation and quantitative realtime PCR - Endothelial permeability assays - Preparation of cream - Clinical trial on dark circles
- RESULTS : SABE increases HA synthesis and regulates HA-related genes in HDF - Conditioned medium produced by HDF reinforces vascular endothelial integrity in HMEC-1 - Effect of SABE on infraorbital dark circles in clinical trial
- Table 1 : Formulation of test and placebo cream
- Table 2 : Dark circles grade scale |
| Référence de l'article : |
https://doi.org/10.1111/ics.12873 |
| En ligne : |
https://drive.google.com/file/d/1obc6x3Pt5lk3aseRPepM4h_TCBrfAukX/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=40090 |
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 45, N° 5 (10/2023) . - p. 636-646
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The effect of Salix alba L. bark extract on dark circles in vitro and in vivo in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 45, N° 5 (10/2023)
