Free radicals induce Acne aestivalis in sensitive subjects / Katinka Jung in PERSONAL CARE EUROPE, Vol. 12, N° 5 (11/2018)  

[article]  inPERSONAL CARE EUROPE > Vol. 12, N° 5 (11/2018) . - P. 66-69 Titre : Free radicals induce Acne aestivalis in sensitive subjects Type de document : texte imprimé Auteurs : Katinka Jung, Auteur ; Thomas Herrling, Auteur ; Ulrike Heinrich, Auteur ; Hagen Tronnier, Auteur ; Marcel Schnyder, Auteur ; Bernd Herzog, Auteur Année de publication : 2018 Article en page(s) : P. 66-69 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Acné L'acné (nom féminin) est une dermatose (maladie de la peau) inflammatoire des follicules pilosébacés (glandes sécrétant le sébum, à la racine des poils) avec formation de comédons. Cette maladie de la peau est représentée dans sa forme la plus fréquente par l'acné polymorphe juvénile qui touche les adolescents, mais qui ne résume pas toutes les acnés. Il existe aussi des acnés exogènes d'origine professionnelle, médicamenteuse, cosmétique... Etudes cliniques Formulation (Génie chimique) Peau -- Physiopathologie Peau -- Soins et hygiène Produits antisolaires Radicaux libres (chimie) Index. décimale : 668.5 Parfums et cosmétiques Résumé : The market segment of sun care products to protect sensitive skin is growing. There is evidence that peroxide free radicals derived from certain formulation components are involved in inducing allergic skin reactions. These UV-induced free radicals can be assessed by an ESR-based method called Radical Potential (RP), by exposing formulations to UV radiation. BASF experts found a correlation between the amount of UV-inducible peroxides in sunscreen products and the clinical symptoms of Acne aestivalis and, potentially, other types of skin reactions. Their findings offer a rationale for developing low-risk sunscreen formulations by selecting suitable filter systems combined with in-situ ESR analysis. Note de contenu : - Assessing the radical potential - Radical Potential method - Clinical study - Fig. 1 : Free radical generation in a cosmetic formulation (placebo) spiked with natural oil or perfume oils (PO) - Fig. 2 : Score evaluation of the clinical study - Table 1 : INCI of the SPF 30 sunscreen formulas 12-1 and 12-2 - Table 2 : Relative amount of free radicals, N=2 - Table 3 : Part 1 : Score value - Table 4 : Evaluation of the adverse skin reaction of treated subjects where 24 is the sum of the highest possible skin reaction (score value 4 x 6 subjects) En ligne : https://drive.google.com/file/d/178PeTFtn_HAAy0Wm8IK12VbwvVj8V1qs/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=31287 [article]

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High levels of free radicals in suncare products induce acne aestivalis in sensitive subjects / Katinka Jung in SOFW JOURNAL, Vol. 142, N° 3 (03/2016)  

[article]  inSOFW JOURNAL > Vol. 142, N° 3 (03/2016) . - p. 2-8 Titre : High levels of free radicals in suncare products induce acne aestivalis in sensitive subjects Type de document : texte imprimé Auteurs : Katinka Jung, Auteur ; Thomas Herrling, Auteur ; Ulrike Heinrich, Auteur ; Hagen Tronnier, Auteur ; Marcel Schnyder, Auteur ; Bernd Herzog, Auteur Année de publication : 2016 Article en page(s) : p. 2-8 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Acné L'acné (nom féminin) est une dermatose (maladie de la peau) inflammatoire des follicules pilosébacés (glandes sécrétant le sébum, à la racine des poils) avec formation de comédons. Cette maladie de la peau est représentée dans sa forme la plus fréquente par l'acné polymorphe juvénile qui touche les adolescents, mais qui ne résume pas toutes les acnés. Il existe aussi des acnés exogènes d'origine professionnelle, médicamenteuse, cosmétique... Cosmétiques -- Toxicologie Peau -- Inflammation Produits antisolaires Radicaux libres (chimie) Index. décimale : 668.5 Parfums et cosmétiques Résumé : The market segment of suncare products for protection of sensitive skin against photodermatosis is growing. Speciflcally, proection against Acne aestivalis ("Mallorca-Acne") is perceived as a strong claim for this product category. There is evidence that peroxide free radicals, deriving from certain formulation components, are involved in the induction of photo-toxic skin reactions. These UV-incluced free radicals can be assessed by an ESR-based method called Radical Potential (RP), by exposing formulations to UV radiation. The aim of this study was to find a correlation between the amount of UV inducible peroxides of sunscreen products and the clinical symptoms of Acne aestivalis. Two sunscreen formulas (SPF 30) containing organic UV-filters only, with an identical protection in the UV B region and a comparable protection in the UV A spectral range, have been produced. For both formulations the amount of UV-inducible free radicals was assessed by the RP (Radical Potential). In addition, bath formulas were tested in a clinical study with subjects with a history of Acne aestivalis. Very different RP values (levels of UV-induced free radicals) and completely different skin reactivity have been obtained, where an excellent correlation between the in vitro-parameter (RP) and the clinical symptoms could be shown. To our knowledge these results for the first time provide direct evidence for a strong correlation between UV inducible free radicals of formulations and the potential to induce A. aestivalis in sensitive subjects. Furthermore it offers a nationale for the development of law risk sunscreen formulations by selection of suitable filter systems combined with in situ ESR analysis. En ligne : https://drive.google.com/file/d/1xcreNyUK6raAM1sApbAVUsl5N9UabkIH/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=26668 [article]

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Impact of photostability and UVA/UVA-blue light protection on free radical generation / Myriam Sohn in SOFW JOURNAL, Vol. 145, N° 7/8 (07-08/2019)  

[article]  inSOFW JOURNAL > Vol. 145, N° 7/8 (07-08/2019) . - p. 2-10 Titre : Impact of photostability and UVA/UVA-blue light protection on free radical generation Type de document : texte imprimé Auteurs : Myriam Sohn, Auteur ; Stanislaw Krus, Auteur ; Marcel Schnyder, Auteur ; Katinka Jung, Auteur ; Marietta Seifert, Auteur Année de publication : 2019 Article en page(s) : p. 2-10 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Cosmétiques -- Analyse Evaluation Formulation (Génie chimique) Lumière bleue Mesure Peau -- Soins et hygiène Produits antisolaires Protection cutanée Radicaux libres (chimie) Rayonnement ultraviolet A Index. décimale : 668.5 Parfums et cosmétiques Résumé : The impact of UV-filter combination on the number of free radicals generated in sunscreen formulations and the skin following UV-VIS irradiation was assessed via electron spin resonance spectroscopy using a spin-probing approach. Four UV-filter combinations that differed in their photostability and range of UVA absorbance coverage were investigated. Fewer free radicals were generated in the sunscreen formulation when a photostable UVA filter system was used, compared to a stabilized UVA filter system. Additionally, fewer free radicals were generated in the skin when a sunscreen with long UVA protection extending to the short visible range was used, compared to a sunscreen with minimal UVA protection. This study showed that the photostability of a UV-filter system is central to the generation of free radicals in a formulation, and that long UVA-blue light protection is key for avoiding the generation of free radicals in the skin. A sunscreen product exhibiting both photostable UVA protection and long UVA-blue light protection is therefore the most appropriate choice for protecting against ROS-induced skin damage. Note de contenu : - MATERIALS AND METHODS : Sunscreen formulations - Measurement of free radicals - UV and blue light transmittance measurements with photostability assessment - RESULTS AND DISCUSSION : Photostability profile of investigated sunscreen formulations - Absorbance profile of organic particulate UV filters - Table 1 : Chassis of the sunscreen formulations used in both studies - Table 2 : Composition of UV-filter combinations in % by weight - Table 3 : Relative quantity of free radicals, N = 2 - Table 4 : Means and standard deviations for N = 3-5 - Fig. 1 : Photostability profile of the investigated sunscreens - Fig. 2 :Free radical formation in the unstable sunscreens as a function of UV irradiation time. Data fitted with a Boltzmann sigmoidal algorithm - Fig. 3 : Long UVA-blue light transmittance of Tinosorb M and Tinosorb A2B at 4%, 7% and 10% - Fig. 4 : UVA-blue light transmittance of UV-filter combinations with varying quantities of particulate organic UV filters : from O% (top curve), to 5.25% (middle curve) and 13.5% of organic particulate UV filters En ligne : https://drive.google.com/file/d/1pU6mF1OhvWam8jSEoNvLW2xn5Gu1dzrM/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=32927 [article]

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New methods for testing skin protection against Noxae using the Bovine Udder Skin (BUS) / Katinka Jung in IFSCC MAGAZINE, Vol. 15, N° 4 (10-11-12/2012)

[article]  inIFSCC MAGAZINE > Vol. 15, N° 4 (10-11-12/2012) . - p. 265-270 Titre : New methods for testing skin protection against Noxae using the Bovine Udder Skin (BUS) Type de document : texte imprimé Auteurs : Katinka Jung, Auteur ; Wolfgang F. Pittermann, Auteur ; Marietta Seifert, Auteur ; Thomas Herrling, Auteur Année de publication : 2012 Article en page(s) : p. 265-270 Note générale : Biobliogr. Langues : Anglais (eng) Catégories : Bovins Etude in vivo Expérimentation animale Mamelle Peau -- Inflammation Produits chimiques -- Toxicologie Protection cutanée Radicaux libres (chimie) Spectroscopie de résonance paramagnétique électronique Tests de toxicité Toxicologie cellulaire Index. décimale : 668.5 Parfums et cosmétiques Résumé : Quantitative and qualitative determination of skin irritation and skin protection through market formulations using an in vitro skin model, the perfused bovine udder (BUS) and different analytical methods, was the objective of the present research. Various noxae that are percutaneously absorbed cause skin irritation and damage through different mechanisms. Cell vitality, signs of inflammation, and the presence of inducible free radicals among the analytical parameters that enable quantification of skin damage. In this study cytotoxic effects were determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and tissue levels of the pre-inflammatory mediator prostaglandin E2 in treated/untreated whole skin biopsies were assessed using an enzyme immunoassay. The inducibility of free radicals was determined by electron resonance spectroscopy techniques. Noxae (standardized chemicals and products) like detergents, coolants, toluene, and n-octane caused reduced cell vitality and metabolic activity, inflammation as evidenced by the presence of prostaglandins, and enhanced values in the inducible free radical status in in vitro bovine udder skin. The effect of the noxae is dose-dependent and permeation time-dependent, allowing construction of dose-effect curves. The induced cytotoxicity and free radical status show a positive correlation, while the inflammatory actions analyzed by the prostaglandin E2 tissue concentration do not. As a consequence, the skin compatibility of noxae and performance of skin protection formulations can be evaluated by the measurement of different cell physiological and biophysical parameters at the very early stages of skin damage. Note de contenu : - Chemicals - Skin protective formulation A - Skin protective formulation B - BUS model - UV irradiation - ESR spectrometer - Determination of the radical skin status factor RSF Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=16885 [article]

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Stable nanoemulsions - versatile applications in cosmetics and pharmacy / Gabriele Blume in SOFW JOURNAL, Vol. 145, N° 5 (05/2019)

[article]  inSOFW JOURNAL > Vol. 145, N° 5 (05/2019) . - p. 30-33 Titre : Stable nanoemulsions - versatile applications in cosmetics and pharmacy Type de document : texte imprimé Auteurs : Gabriele Blume, Auteur ; Katinka Jung, Auteur ; Fischer Dagmar, Auteur Année de publication : 2019 Article en page(s) : p. 30-33 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Cosmétiques Emulsions -- Emploi en cosmétologie Médicaments -- Administration par voie cutanée Nanoémulsions Peau -- Soins et hygiène Index. décimale : 668.5 Parfums et cosmétiques Résumé : The major disadvantage in dermal drug delivery is the low penetration rate of active ingredients into the skin. To over¬corne this challenge vesicular carrier systems have gained a wide attention especially in the field of nanotechnology like e.g. liposomes, ethosomes or lipid nanoparticles. Also nanoemulsions are considered to be promising candidates for dermal drug delivery with the advantage of low skin irritation, high drug loading capacity and drug penetration enhancement. Among them new stable anionic nanoemulsions based on the membrane-forming emulsifier "Glyceryl Citrate/Lactate/ Linoleate/Oleate", an eatable and skin friendly emulsifier de¬rived from sunflower, became superior over other vesicular carriers. Depending on the usage of additional emollients/ oils and stabilizers two different emulsions can be obtained: a multiple water-in-oil-in-water nanoemulsion (Hydro-Tops®) or an oil-in-water nanoemulsion (Lipo-Tope). Note de contenu : - Structures of the different nano-vesicles - Vesicle sizes and polydispersity index - Toxicity - Hydro-tops EGCG - Lipo-tops tocopherol - Fig. 1 : Structures of different nanovesicles - Fig. 2 : Stability of encapsulated EGCG - Fig. 3 : Autioxidative power of different EGCG formulations - Fig. 4 : Antioxidative power of different vitamin E formulations - Table 1 : Vesicle sizes and polydispersity Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=32729 [article]

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