Arnica montana L. extract containing 6-O-methacryloylhelenalin and 6-O-isobutyrylhelenalin accelerates growth and differentiation of human subcutaneous preadipocytes and leads volumizing of skin / Kotaro Sakamoto in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 45, N° 1 (02/2023)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 45, N° 1 (02/2023) . - p. 1-13 Titre : Arnica montana L. extract containing 6-O-methacryloylhelenalin and 6-O-isobutyrylhelenalin accelerates growth and differentiation of human subcutaneous preadipocytes and leads volumizing of skin Type de document : document électronique Auteurs : Kotaro Sakamoto, Auteur ; Chiharu Watanabe, Auteur ; Teruaki Masutani, Auteur ; Asuka Hirasawa, Auteur ; Kanae Wakamatsu, Auteur ; Arunasiri Iddamalgoda, Auteur ; Yuya Kakumu, Auteur ; Kosei Yamauchi, Auteur ; Tohru Mitsunaga, Auteur Année de publication : 2023 Article en page(s) : p. 1-13 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Adipocytes Antiâge:Antirides Arnica et constituants Arnica est un genre d'environ 30 espèces de plantes pérennes, herbacées, appartenant à la famille des Asteraceae. Ce genre montagnard se développe essentiellement dans les régions tempérées néarctiques (Amérique du Nord). Seules deux espèces sont natives des régions paléarctiques (Eurasie) : Arnica angustifolia et Arnica montana. En médecine traditionnelle, l'usage de l'arnica des montagnes est décrit dans des pharmacopées européennes pour son usage sur le traitement de petits traumatismes comme les hématomes, troubles menstruels, mais cet usage n'est pas soutenu par des études scientifiques. Cellules -- Cultures et milieux de culture Chimie analytique Dermo-cosmétologie Extraits de plantes:Extraits (pharmacie) Peau -- Soins et hygiène Repulpant (cosmétique) Tests de sécurité Index. décimale : 668.5 Parfums et cosmétiques Résumé : Objective : An important factor in the aging of the face is a reduction in the volume of adipose tissue. This reduction in adipose tissue contributes to decreased skin elasticity, which is also part of the aging process. Overall, these lead to wrinkle formation. Fat injection is a common means of addressing this issue and is used to reduce the effects of aging on the face and to increase the fullness of the lips and breasts. However, fat injection is an invasive surgical procedure. This study aimed to discover novel cosmetic ingredients that increase the volume of subcutaneous (pre)adipocytes to create the appearance of more youthful skin. - Methods : We focused on the number of subcutaneous preadipocytes and the accumulation of lipid droplets. To discover natural ingredients that increase both of these, extracts of 380 natural products were prepared and screened for their effects on both growth and differentiation (i.e., lipid droplet accumulation) of human subcutaneous preadipocytes. One extract was found to have the desired effects, and this was further studied to determine the active compounds. We then evaluated its efficacy in a human clinical study. - Results : We found that Arnica montana L. flower extract (AFE) accelerates both the growth and the differentiation of human subcutaneous preadipocytes. AFE was found to significantly increase the volume of adipocyte spheroids. The active compounds 6-O-methacryloylhelenalin and 6-O-isobutyrylhelenalin were found to be responsible for the effects of AFE on preadipocytes. In a human clinical study, gels containing 1% AFE successfully enhanced the volume of the lips and face with reduction of wrinkles with no adverse reactions. - Conclusion : This is the first report to demonstrate that AFE and the included compounds, 6-O-methacryloylhelenalin and 6-O-isobutyrylhelenalin, act on preadipocytes. AFE would be ideal for use in products that plump the face to reduce wrinkles and create a more youthful appearance. Note de contenu : - MATERIALS AND METHODS : Plant extracts preparation - In vitro cell-based assay - Evaluation of adiponectin secretion - Preparation of cell spheroids - Evaluation of lipid droplet amount in spheroids - Fractionation and identification of active compounds of AFE - Ethics statement - Chemical trials - Statistics analysis - RESULTS : Screening of 380 natural extracts for their effects on the growth and differentiation of preadipocytes - AFE activation of subcutaneous preadipocytes - AFE volumizing effects on adipocytes spheroids (3D-cultured cells) - Active compounds responsible for the effects of AFE on preadipocytes - Volumizing and wrinkle-reducing effects of AFE on human skin DOI : https://doi.org/10.1111/ics.12815 En ligne : https://drive.google.com/file/d/1a9DVvVwVnqDJA4DkGFZOmqmp_Alfg-za/view?usp=share [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=38815 [article]

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Effects of watercress extract fraction on R-spondin 1-mediated growth of human hair / Masakazu Hashimoto in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 44, N° 2 (04/2022)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 44, N° 2 (04/2022) . - p. 154-165 Titre : Effects of watercress extract fraction on R-spondin 1-mediated growth of human hair Type de document : document électronique Auteurs : Masakazu Hashimoto, Auteur ; Yuka Kawai, Auteur ; Teruaki Masutani, Auteur ; Kiyotaka Tanaka, Auteur ; Kenichi Ito, Auteur ; Arunasiri Iddamalgoda, Auteur Année de publication : 2022 Article en page(s) : p. 154-165 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Alopécie Cheveux -- Croissance Cheveux -- Soins et hygiène Cheveux gris Cresson et constituants Cuir chevelu -- Soins et hygiène Extraits de plantes:Extraits (pharmacie) Produits capillaires Tests de sécurité Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Hair loss and greying affect men and women of all ages, often causing psychosocial difficulties. Dickkopf-1 (DKK1), a major hair loss factor secreted from dermal papilla (DP) cells in response to the secretion of dihydrotestosterone (DHT), has been reported to induce and accelerate androgenetic alopecia (AGA). In addition, DKK1 acts as a potent suppressor of melanogenesis and is closely related to hair colour. R-spondin 1 (RSPO1) is a secretory agonist of Wnt signalling known to antagonize the effects of DKK1, including DKK1-mediated hair follicle suppression. In this study, we investigated the effect of watercress extract (WCE) on the secretion of RSPO1 and DKK1 from DP cells as well as its anti-hair loss effect in human hair follicles and patients. - Methods : The in vitro secretion of RSPO1 and DKK1 was measured by ELISA. Human hair follicles were collected from the scalp of a female donor and used for ex vivo organ culture to investigate the effects of WCE on human hair loss. Finally, a 6-month human clinical trial was conducted to examine the effect of WCE-containing lotion on hair growth in a male panel. - Results : WCE significantly upregulated RSPO1 secretion and suppressed DKK1 secretion in a dose-dependent manner, even in the presence of DHT. WCE-treated hair follicles elongated 1.6-fold compared with the control, and the level of RSPO1 production in DP as well as RSPO1 bound to the outer root sheath (ORS) increased. In the clinical trial, the hair lotion containing 2% WCE increased hair thickness and density to improve against hair loss symptoms. - Conclusion : WCE exhibited a strong anti-androgenic effect through its ability to suppress DKK1 secretion and antagonize DKK1 via RSPO1. These findings highlighted the potential use of WCE for the treatment of hair loss. Note de contenu : - MATERIALS AND METHODS : Fractionation and identification of WCE components - Treatment with RSPO1, DKK1 and Wnt-3a - Measurements of protein secretion from DP cells - Elongation and immunohistochemistry of hair follicle ex vivo - Statistical analyses - RESULTS : Enhancement of Wnt signalling by RSPO1 - Effect of WCE on RSPO1 and DKK1 secretion in DP cells - Hair follicle elongation ex vivo - Clinical trial DOI : https://doi.org/10.1111/ics.12764 En ligne : https://drive.google.com/file/d/1mEtlNb-0EHtJAaI-UEiACOIUsnbeQepv/view?usp=shari [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=37719 [article]

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Melanosome transportation control via innovative active / Kiyotaka Tanaka in PERSONAL CARE EUROPE, Vol. 8, N° 6 (11/2015)  

[article]  inPERSONAL CARE EUROPE > Vol. 8, N° 6 (11/2015) . - p. 41-44 Titre : Melanosome transportation control via innovative active Type de document : texte imprimé Auteurs : Kiyotaka Tanaka, Auteur ; Arunasiri Iddamalgoda, Auteur Année de publication : 2015 Article en page(s) : p. 41-44 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Agents de blanchiment Biomolécules actives Kinésine Mélanosome Index. décimale : 668.5 Parfums et cosmétiques Résumé : Various biological parts and structures are formed within cells and transported to parts of the body by driving proteins called motor proteins. For example, melanin pigment that influences skin tone is produced in melanocytes and passed to keratinocytes through dendrites. Keratinocytes absorb melanin from surrrounding areas (or tips of dendrites including melanin) and darken. Usually, melanin generated in melanocytes is transported to the end of dendrites. In this process, melanosomes are transported by kinesin, a type of motor protein. Melanin is transported along dendrites while it is synthesised in sacks called melanosomes. Kinesin is involved in the transport of melanosomes to the end of dendrites (Fig. 1). Kinesin is a protein with limb-like strutures. Kinesin holds up melanosome using hand-like strutures (light chains) and walks on microtubules using leg-like structures (heavy chains). Kinesins travel in a specific direction, always toward the end of dendrites, namely keratinocytes. They move leg-like structures alternately as though they are walking; Since they look like micro robots, they are also know as 'biological nanomachines'. Note de contenu : - Kinesin as a new target of skin lightening - Development of a plant based kinesin inhibitor - Inhibition of melanin transportation - Skin lightening effect on 3D skin model - Clinical study on human skin - Identifying active molecule - Relationship between skin lightening and 'Cinderella time' - New skin lightening theory En ligne : https://drive.google.com/file/d/1PfSLWr4J3wXvuzO_h1qWuqxOgrx7Ohl4/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=24936 [article]

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New approach to suppressing wrinkles / Yukiko Fujita in GLOBAL PERSONAL CARE, Vol. 22, N° 9 (10/2021)  

[article]  inGLOBAL PERSONAL CARE > Vol. 22, N° 9 (10/2021) . - p. 65-67 Titre : New approach to suppressing wrinkles Type de document : texte imprimé Auteurs : Yukiko Fujita, Auteur ; Kazal Boron Biswas, Auteur ; Arunasiri Iddamalgoda, Auteur Année de publication : 2021 Article en page(s) : p. 65-67 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge:Antirides Cosmétiques Dermo-cosmétologie Extraits de plantes:Extraits (pharmacie) Ingrédients cosmétiques Menthe et constituants Peau -- Soins et hygiène Index. décimale : 668.5 Parfums et cosmétiques Résumé : Skin-thinning in aged skin is considered an important factor in the formation of wrinkles. Due to natural ageing of the epidermal keratinocytes, there is a remarkable production of senescenceassociated secretory phenotype (SASP) factor, which induces matrix metalloproteinase-1 production in dermal fibroblasts, resulting in dermal thinning. Meanwhile, extracellular ATP (eATP) is known to induce the production of SASP factors, but the relationship between eATP and natural ageing is unknown. In this study, we showed the relationship between the increase of eATP in the epidermis and the dermal thinning seen with natural ageing. Peppermint leaf extract (PME) effectively suppressed the rise in eATP concentration due to natural ageing and environmental stress. Furthermore, PME suppressed skin thinning and improved various wrinkles, such as crow’s feet and neck wrinkles. These results suggest that PME is an antiageing material that suppresses eATPmediated dermal thinning and effectively improves wrinkles in many areas. Note de contenu : - Testing PME - Human clinical study - Effects on crow's feet & neck wrinkles - Evaluation En ligne : https://drive.google.com/file/d/1yZIvPCS9ynQHaqx5T301sPK2dei9-X1m/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=36896 [article]

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Une nouvelle approche de protection anti-UVs / Arunasiri Iddamalgoda in EXPRESSION COSMETIQUE, N° Hors série (12/2017)  

[article]  inEXPRESSION COSMETIQUE > N° Hors série (12/2017) . - p. 302-306 Titre : Une nouvelle approche de protection anti-UVs Type de document : texte imprimé Auteurs : Arunasiri Iddamalgoda, Auteur ; Hideo Yamaguchi, Auteur ; Kazal Boron Biswas, Auteur ; Satoru Takayama, Auteur Année de publication : 2017 Article en page(s) : p. 302-306 Note générale : Bibliogr. Langues : Multilingue (mul) Catégories : Anti-inflammatoires Biomolécules actives Peau -- Effets du rayonnement solaire Peau -- Soins et hygiène Produits antisolaires Index. décimale : 668.5 Parfums et cosmétiques Résumé : Une exposition excessive à la lumière du soleil, en particulier aux rayons UV, peut nuire à la santé de plusieurs façons. A court terme, par une réaction inflammatoire de la peau communément appelée coup de soleil. A long terme, par un risque majeur de vieillissement prématuré et de cancer de la peau. Le but de cette étude sera de présenter un ingrédient actif naturel issu de la science innovante et qui permettra d'améliorer la performance des produits de protection solaire. Note de contenu : - Les DAMPs et l'inflammation induite par les UVs - Présentation d'Izayoi - Protection contre l'exposition au soleil : Inhibition des cytokines générées par les UVBs - Suppression de l'activation des kératinocytes par les auto-ARN induits par les UVBs - Test clinique évalué dermatologiquement - Inhibition de l'érythème solaire - Protection solaire - Réduction de l'indice de mélanine En ligne : https://drive.google.com/file/d/1Fo_23Se4jR8D8jJ8Vroe50UxMgTHl7S7/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=29720 [article]

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PrincessCare : Solution anti-âge novatrice / Arunasiri Iddamalgoda in EXPRESSION COSMETIQUE, N° 26 (03-04/2014)  

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Protection against pollution-induced skin ageing by a natural cosmetic ingredient / Arunasiri Iddamalgoda in SOFW JOURNAL, Vol. 142, N° 4 (04/2016)  

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A solution for pollution-induced ageing of skin / Kazal Boron Biswas in PERSONAL CARE EUROPE, Vol. 11, N° 2 (04/2017)  

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Taking a regenerative approach to hair growth / Masakazu Hashimoto in PERSONAL CARE EUROPE, Vol. 14, N° 3 (06/2020)  

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