Effects of watercress extract fraction on R-spondin 1-mediated growth of human hair / Masakazu Hashimoto in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 44, N° 2 (04/2022)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 44, N° 2 (04/2022) . - p. 154-165 Titre : Effects of watercress extract fraction on R-spondin 1-mediated growth of human hair Type de document : document électronique Auteurs : Masakazu Hashimoto, Auteur ; Yuka Kawai, Auteur ; Teruaki Masutani, Auteur ; Kiyotaka Tanaka, Auteur ; Kenichi Ito, Auteur ; Arunasiri Iddamalgoda, Auteur Année de publication : 2022 Article en page(s) : p. 154-165 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Alopécie Cheveux -- Croissance Cheveux -- Soins et hygiène Cheveux gris Cresson et constituants Cuir chevelu -- Soins et hygiène Extraits de plantes:Extraits (pharmacie) Produits capillaires Tests de sécurité Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Hair loss and greying affect men and women of all ages, often causing psychosocial difficulties. Dickkopf-1 (DKK1), a major hair loss factor secreted from dermal papilla (DP) cells in response to the secretion of dihydrotestosterone (DHT), has been reported to induce and accelerate androgenetic alopecia (AGA). In addition, DKK1 acts as a potent suppressor of melanogenesis and is closely related to hair colour. R-spondin 1 (RSPO1) is a secretory agonist of Wnt signalling known to antagonize the effects of DKK1, including DKK1-mediated hair follicle suppression. In this study, we investigated the effect of watercress extract (WCE) on the secretion of RSPO1 and DKK1 from DP cells as well as its anti-hair loss effect in human hair follicles and patients. - Methods : The in vitro secretion of RSPO1 and DKK1 was measured by ELISA. Human hair follicles were collected from the scalp of a female donor and used for ex vivo organ culture to investigate the effects of WCE on human hair loss. Finally, a 6-month human clinical trial was conducted to examine the effect of WCE-containing lotion on hair growth in a male panel. - Results : WCE significantly upregulated RSPO1 secretion and suppressed DKK1 secretion in a dose-dependent manner, even in the presence of DHT. WCE-treated hair follicles elongated 1.6-fold compared with the control, and the level of RSPO1 production in DP as well as RSPO1 bound to the outer root sheath (ORS) increased. In the clinical trial, the hair lotion containing 2% WCE increased hair thickness and density to improve against hair loss symptoms. - Conclusion : WCE exhibited a strong anti-androgenic effect through its ability to suppress DKK1 secretion and antagonize DKK1 via RSPO1. These findings highlighted the potential use of WCE for the treatment of hair loss. Note de contenu : - MATERIALS AND METHODS : Fractionation and identification of WCE components - Treatment with RSPO1, DKK1 and Wnt-3a - Measurements of protein secretion from DP cells - Elongation and immunohistochemistry of hair follicle ex vivo - Statistical analyses - RESULTS : Enhancement of Wnt signalling by RSPO1 - Effect of WCE on RSPO1 and DKK1 secretion in DP cells - Hair follicle elongation ex vivo - Clinical trial DOI : https://doi.org/10.1111/ics.12764 En ligne : https://drive.google.com/file/d/1mEtlNb-0EHtJAaI-UEiACOIUsnbeQepv/view?usp=shari [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=37719 [article]

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Melanosome transportation control via innovative active / Kiyotaka Tanaka in PERSONAL CARE EUROPE, Vol. 8, N° 6 (11/2015)  

[article]  inPERSONAL CARE EUROPE > Vol. 8, N° 6 (11/2015) . - p. 41-44 Titre : Melanosome transportation control via innovative active Type de document : texte imprimé Auteurs : Kiyotaka Tanaka, Auteur ; Arunasiri Iddamalgoda, Auteur Année de publication : 2015 Article en page(s) : p. 41-44 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Agents de blanchiment Biomolécules actives Kinésine Mélanosome Index. décimale : 668.5 Parfums et cosmétiques Résumé : Various biological parts and structures are formed within cells and transported to parts of the body by driving proteins called motor proteins. For example, melanin pigment that influences skin tone is produced in melanocytes and passed to keratinocytes through dendrites. Keratinocytes absorb melanin from surrrounding areas (or tips of dendrites including melanin) and darken. Usually, melanin generated in melanocytes is transported to the end of dendrites. In this process, melanosomes are transported by kinesin, a type of motor protein. Melanin is transported along dendrites while it is synthesised in sacks called melanosomes. Kinesin is involved in the transport of melanosomes to the end of dendrites (Fig. 1). Kinesin is a protein with limb-like strutures. Kinesin holds up melanosome using hand-like strutures (light chains) and walks on microtubules using leg-like structures (heavy chains). Kinesins travel in a specific direction, always toward the end of dendrites, namely keratinocytes. They move leg-like structures alternately as though they are walking; Since they look like micro robots, they are also know as 'biological nanomachines'. Note de contenu : - Kinesin as a new target of skin lightening - Development of a plant based kinesin inhibitor - Inhibition of melanin transportation - Skin lightening effect on 3D skin model - Clinical study on human skin - Identifying active molecule - Relationship between skin lightening and 'Cinderella time' - New skin lightening theory En ligne : https://drive.google.com/file/d/1PfSLWr4J3wXvuzO_h1qWuqxOgrx7Ohl4/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=24936 [article]

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Protection against pollution-induced skin ageing by a natural cosmetic ingredient / Arunasiri Iddamalgoda in SOFW JOURNAL, Vol. 142, N° 4 (04/2016)  

[article]  inSOFW JOURNAL > Vol. 142, N° 4 (04/2016) . - p. 8-13 Titre : Protection against pollution-induced skin ageing by a natural cosmetic ingredient Type de document : texte imprimé Auteurs : Arunasiri Iddamalgoda, Auteur ; Kazal Boron Biswas, Auteur ; Kiyotaka Tanaka, Auteur ; Satoru Takayama, Auteur Année de publication : 2016 Article en page(s) : p. 8-13 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge:Antirides Extraits de plantes:Extraits (pharmacie) Ingrédients cosmétiques Particules fines Peau -- Effets de la pollution atmosphérique Peau -- Soins et hygiène Polluants atmosphériques Pollution -- Effets physiologiques Produits naturels Tabac -- Effets physiologiques Vieillissement cutané -- Prévention Index. décimale : 668.5 Parfums et cosmétiques Résumé : Environmental pollution now-a-days is considered one of the main causes of skin ageing. Among the pollutants, tobacco smoke and PM2.5 (particulate matter) are thought to be the major health hazardous components responsible for skin in-flammation, pigmentation, and wrinkling, as evident from sporadic clinical and epidemiological studies. Our objective was to develop a plant-based natural ingredient that could suppress the detrimental effects of those two pro-minent pollutants on human skin tells. Normal human epidermal keratinocytes (NHEK) and normal human dermal fibroblasts (NHDF) were exposed to PM2.5 and tobacco smoke, respectively, for the induction of inflammation and collagenase activity. Various plant extracts were screened for their efficacy in showing anti-ageing properties against these pollutants. We showed that our unique extract, Ougon, was able to suppress the tobacco smoke-induced expression of matrix metalloproteinase-1 (an enzyme responsible for the degradation of extracellular matrix) in NHDF by inhibiting the expression of CYP1B1 (a member of the cytochrome p450 family). Moreover, Ougon was found to have strong efficacy in inhibiting the PM2.5-induced expression of some inflammatory mediators (e.g. IL-113, IL-6, and IL-8) in NHEK in concentration-dependent manners. Therefore, we suggest that Ougon extract may protect the MMP-1 and inflammation-mediated ageing of skin induced by environmental stress factors. En ligne : https://drive.google.com/file/d/1naDB1gpwo9TNHkx0Fn4gdzbGC-3cvcWQ/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=26686 [article]

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A solution for pollution-induced ageing of skin / Kazal Boron Biswas in PERSONAL CARE EUROPE, Vol. 11, N° 2 (04/2017)  

[article]  inPERSONAL CARE EUROPE > Vol. 11, N° 2 (04/2017) . - p. 131-134 Titre : A solution for pollution-induced ageing of skin Type de document : texte imprimé Auteurs : Kazal Boron Biswas, Auteur ; Kiyotaka Tanaka, Auteur ; Satoru Takayama, Auteur ; Arunasiri Iddamalgoda, Auteur Année de publication : 2017 Article en page(s) : p. 131-134 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge Cosmétiques Extraits de plantes:Extraits (pharmacie) Peau -- Effets de la pollution atmosphérique Peau -- Soins et hygiène Protection cutanée Tabac -- Effets physiologiques Index. décimale : 668.5 Parfums et cosmétiques Résumé : For the last 20-30 years UV was really the main topic in skin care science. Until recently, people might not have been aware of the detrimentaI effects of environmental pollution on skin mainly because UV was thought to be the one to cause extrinsic skin ageing. Nowadays, people have come to know that pollutants have harmful affects similar to that of UV on skin, and also that pollutants in combination with UV may have greater impact on skin because of the production of ozone from photochemical reactions between the pollutants, heat, and UV. One of the pollutants is tobacco smoke, which is well-known for its harmful effects on health, and another is PM2.5, against which scientists have already declared war all over the world. People are now looking for solutions to the harmful affects of pollution. We have been conducting exclusive research on environmental factor-induced skin ageing for many years. Among these factors we investigated tobacco smoke and PM2.5's relationship with skin ageing with the aim of developing a natural-based cosmetic ingredient to be used in cosmetic formulations. We could provide one optimistic solution that ougon extract could be an ideal cosmetic ingredient for manufacturers willing to develop an anti-ageing finished product based on skin care against environmental pollution, particularly tobacco smoke and PM2.5. Note de contenu : - AIR POLLUTION AND ITS MECHANISM OF ACTION - FIGURES : 1. Inhibition of tobacco smoke (extracted in an organic solvent, hexane)-induced expression of CYP1B1 in human cultured fibroblasts by ougon - 2. Reduction of MMP-1 expression induced by oil (a) and water (b) soluble components of tobacco smoke by ougon - 3. Down-regulation of PM2.5-induced expression of CYP1A1 by ougon in NHEK - 4. Inhibition of PM2.5-induced expression of CYP1B1 in NHEK by ougon - 5. Suppression of mRNA expression of IL-1b induced by PM2.5 in human cultured keratinocytes - 6. Down-regulation of PM2.5-induced expression of IL-6 in NHEK by ougon - 7. Dose-dependent inhibition of IL-8 expression induced by PM2.5 in human cultured keratinocytes by ougon - 8. Ougon significantly reduced the formation of wrinkle (a) and improved skin elasticity (b) on human skin - 9. Ougon decreased pigmented spots as well as melanin index on the faces of smokers significantly En ligne : https://drive.google.com/file/d/1NJlrChGyqH7tx-Aoz1JI6esQcoUDz1V8/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=28351 [article]

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