Development of SEDDS formulation containing caffeine for dermal delivery / Igor de Andrade Assunção de Almeida in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 45, N° 2 (03-04/2023)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 45, N° 2 (03-04/2023) . - p. 255-265 Titre : Development of SEDDS formulation containing caffeine for dermal delivery Type de document : document électronique Auteurs : Igor de Andrade Assunção de Almeida, Auteur ; Thiago da Silva Honório, Auteur ; Flavia Almada do Carmo, Auteur ; Zaida Maria Faria de Freitas, Auteur ; Lucio Mendes Cabral, Auteur ; Letícia Coli Louvisse de Abreu, Auteur Année de publication : 2023 Article en page(s) : p. 255-265 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Amincissants Caféine Caractérisation Cellules -- Cultures et milieux de culture Cellulite Dermo-cosmétologie Emulsions -- Emploi en cosmétologie Essais (technologie) Formulation (Génie chimique) Médicaments -- Administration par voie cutanée Nanoémulsions Peau -- Soins et hygiène Perméation Potentiel zeta Solubilité Taille des gouttelettes Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : The objective of this work was to develop a self-emulsifying drug delivery system (SEDDS) containing caffeine for the treatment of cellulite. - Methods : SEDDS were prepared using the solution method. 0.5% (w/v) caffeine was added to the previously selected excipients. The system was characterized by droplet size, zeta potential, emulsification time and long-term stability. In vitro release and skin permeation were investigated using Franz-type diffusion cells. The cytotoxicity was evaluated on normal human keratinocytes. - Results : Caffeine SEDDS were thermodynamically stable, with a zeta potential less than - 22 mV and droplet size around 30 nm, and were long-term stable. The permeation study showed that the formulation promoted caffeine accumulation in the skin layers, suggesting an increase in local circulation. Cytotoxicity studies on HaCaT cells were not conclusive as the surfactant used indicated false-positive results due to its high molar mass. - Conclusion : It was possible to obtain a stable SEDDS that could cause an increase in blood flow in the applied area, resulting in cellulite reduction. Note de contenu : - MATERIALS AND METHODS : Preparations of self-emulsifying drug delivery systems - Characterization of self-emulsifying drug delivery systems - Measurement of droplet size, polydispersity index and zeta potential - Cytotoxicity evaluation in HaCaT cells - Statistical analysis - RESULTS AND DISCUSSION : Preparation of SEDDS caffeine formulations - Characterization of SEDDS - Evaluation of the permeation profile - Formulation safety - Table 1 : SEDDS formulations - Table 2 : Nanoemulsion classification system - Table 3 : Solubility tests - Table 4 : Droplet size results - Table 5 : Initial zeta potential and after 6 months - Table 6 : Stability study T0 and T6 months DOI : https://doi.org/10.1111/ics.12841 En ligne : https://drive.google.com/file/d/1-ASq7IknoSSPuChlSeOqGI4aCCpdvrOi/view?usp=share [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=39175 [article]

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Preparation and evaluation of caffeine bioadhesive emulgels for cosmetic applications based on formulation design using QbD tools / Y. de Lafuente in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 42, N° 6 (12/2020)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 42, N° 6 (12/2020) . - p. 548-556 Titre : Preparation and evaluation of caffeine bioadhesive emulgels for cosmetic applications based on formulation design using QbD tools Type de document : document électronique Auteurs : Y. de Lafuente, Auteur ; Maria Emma Parente, Auteur ; M. C. Palena, Auteur ; A. F. Jimenez-Kairuz, Auteur Année de publication : 2020 Article en page(s) : p. 548-556 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Adhésifs biologiques Caféine Caractérisation Cosmétiques Emulsions -- Stabilité Formulation (Génie chimique) Gels -- Emploi en cosmétologie Médicaments -- Administration par voie cutanée Médicaments dermatologiques Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : The aim of the present study was to evaluate the influence of the incorporation of caffeine as a model active ingredient on the quality attributes of a bioadhesive emulgel formulation previously optimized by Quality by Design (QbD) tools. Emulgels are emerging topical drug delivery systems for cosmetic or pharmaceutical uses, which combine the advantages of both emulsions and gels. - Methods : In this work, the observed and predicted values for spreadability, phase separation by centrifugation and detachment forces performed by texturometer were compared with those of the control and active‐containing emulgel formulations. In addition, rheological properties, release of caffeine and comparative in vitro/ex vivo bioadhesion properties were evaluated using human skin. - Results : The flow curves of emulgel formulations showed the typical pseudoplastic and no thixotropic flow with yield stress. The incorporation of active ingredient did not produce significant changes. All emulgels were uniformly spread and no significant differences in spreadability values between control and caffeine containing formulations and neither respect to those predicted values from experimental design optimization were found. Emulgel formulations showed appropriate detachment forces values and no significant differences between caffeine loading and control emulgel formulations were observed. - Conclusion : Caffeine was successfully vehiculized in this optimized bioadhesive emulgel formulation, which showed high robustness regarding the process variability. There were no significant changes in the critical quality attributes after the incorporation of the active ingredient and a promising stability was observed for at least one year. Results suggested that the optimized emulgel is an interesting topical biodhesive delivery system for cosmetic applications, including agents for skin conditioning, not present in gels formulations. Note de contenu : - MATERIALS AND METHODS : Materials - Preparation of emulgels - Preparation of compounded creams - Characterization of emulgels - Skin membrane preparation - Determination of Caffeine concentration by HPLC - Stability evaluation - Data analysis - RESULTS AND DISCUSSION : Rheological studies - Spreadability - Physical stability - Adhesion and bioadhesion properties - Drug release studies - Stability evaluation - Table 1 : Qualitative and quantitative formula of optimized emulgel - Table 2 : Quality attributes of freshly prepared emulgels (time = 0) and stored at 25°C and 60% RH during 1 year. Data expressed as main values with standard deviations (N = 3) - Table 3 : Detachment forces (Fdetach) of emulgel and compounded creams loaded with CAF and control formulations, measured at 32°C - Table 4 : In vitro release parameters of caffeine from emulgel and compounded cream using diffusional Higuchi kinetic model. Both formulations contained 10 mg mL-1 of caffeine DOI : https://doi.org/10.1111/ics.12638 En ligne : https://drive.google.com/file/d/1kDZNJlS5f3c8X1MarU4uVFf8JZ4POw7R/view?usp=shari [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=35420 [article]

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Stable nanoemulsions - versatile applications in cosmetics and pharmacy / Gabriele Blume in SOFW JOURNAL, Vol. 145, N° 5 (05/2019)

[article]  inSOFW JOURNAL > Vol. 145, N° 5 (05/2019) . - p. 30-33 Titre : Stable nanoemulsions - versatile applications in cosmetics and pharmacy Type de document : texte imprimé Auteurs : Gabriele Blume, Auteur ; Katinka Jung, Auteur ; Fischer Dagmar, Auteur Année de publication : 2019 Article en page(s) : p. 30-33 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Cosmétiques Emulsions -- Emploi en cosmétologie Médicaments -- Administration par voie cutanée Nanoémulsions Peau -- Soins et hygiène Index. décimale : 668.5 Parfums et cosmétiques Résumé : The major disadvantage in dermal drug delivery is the low penetration rate of active ingredients into the skin. To over¬corne this challenge vesicular carrier systems have gained a wide attention especially in the field of nanotechnology like e.g. liposomes, ethosomes or lipid nanoparticles. Also nanoemulsions are considered to be promising candidates for dermal drug delivery with the advantage of low skin irritation, high drug loading capacity and drug penetration enhancement. Among them new stable anionic nanoemulsions based on the membrane-forming emulsifier "Glyceryl Citrate/Lactate/ Linoleate/Oleate", an eatable and skin friendly emulsifier de¬rived from sunflower, became superior over other vesicular carriers. Depending on the usage of additional emollients/ oils and stabilizers two different emulsions can be obtained: a multiple water-in-oil-in-water nanoemulsion (Hydro-Tops®) or an oil-in-water nanoemulsion (Lipo-Tope). Note de contenu : - Structures of the different nano-vesicles - Vesicle sizes and polydispersity index - Toxicity - Hydro-tops EGCG - Lipo-tops tocopherol - Fig. 1 : Structures of different nanovesicles - Fig. 2 : Stability of encapsulated EGCG - Fig. 3 : Autioxidative power of different EGCG formulations - Fig. 4 : Antioxidative power of different vitamin E formulations - Table 1 : Vesicle sizes and polydispersity Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=32729 [article]

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