| Titre : |
Development of SEDDS formulation containing caffeine for dermal delivery |
| Type de document : |
document électronique |
| Auteurs : |
Igor de Andrade Assunção de Almeida, Auteur ; Thiago da Silva Honório, Auteur ; Flavia Almada do Carmo, Auteur ; Zaida Maria Faria de Freitas, Auteur ; Lucio Mendes Cabral, Auteur ; LetÃcia Coli Louvisse de Abreu, Auteur |
| Année de publication : |
2023 |
| Article en page(s) : |
p. 255-265 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Amincissants
Caféine
Caractérisation
Cellules -- Cultures et milieux de culture
Cellulite
Dermo-cosmétologie
Emulsions -- Emploi en cosmétologie
Essais (technologie)
Formulation (Génie chimique)
Médicaments -- Administration par voie cutanée
Nanoémulsions
Peau -- Soins et hygiène
Perméation
Potentiel zeta
Solubilité
Taille des gouttelettes
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
- Objective : The objective of this work was to develop a self-emulsifying drug delivery system (SEDDS) containing caffeine for the treatment of cellulite.
- Methods : SEDDS were prepared using the solution method. 0.5% (w/v) caffeine was added to the previously selected excipients. The system was characterized by droplet size, zeta potential, emulsification time and long-term stability. In vitro release and skin permeation were investigated using Franz-type diffusion cells. The cytotoxicity was evaluated on normal human keratinocytes.
- Results : Caffeine SEDDS were thermodynamically stable, with a zeta potential less than - 22 mV and droplet size around 30 nm, and were long-term stable. The permeation study showed that the formulation promoted caffeine accumulation in the skin layers, suggesting an increase in local circulation. Cytotoxicity studies on HaCaT cells were not conclusive as the surfactant used indicated false-positive results due to its high molar mass.
- Conclusion : It was possible to obtain a stable SEDDS that could cause an increase in blood flow in the applied area, resulting in cellulite reduction. |
| Note de contenu : |
- MATERIALS AND METHODS : Preparations of self-emulsifying drug delivery systems - Characterization of self-emulsifying drug delivery systems - Measurement of droplet size, polydispersity index and zeta potential - Cytotoxicity evaluation in HaCaT cells - Statistical analysis
- RESULTS AND DISCUSSION : Preparation of SEDDS caffeine formulations - Characterization of SEDDS - Evaluation of the permeation profile - Formulation safety
- Table 1 : SEDDS formulations
- Table 2 : Nanoemulsion classification system
- Table 3 : Solubility tests
- Table 4 : Droplet size results
- Table 5 : Initial zeta potential and after 6 months
- Table 6 : Stability study T0 and T6 months |
| DOI : |
https://doi.org/10.1111/ics.12841 |
| En ligne : |
https://drive.google.com/file/d/1-ASq7IknoSSPuChlSeOqGI4aCCpdvrOi/view?usp=share [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=39175 |
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 45, N° 2 (03-04/2023) . - p. 255-265
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Development of SEDDS formulation containing caffeine for dermal delivery in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 45, N° 2 (03-04/2023)
