Cutaneous restructuration by apple seed phytosterols : from DNA chip analysis to morphological alteration / Thomas Doering in IFSCC MAGAZINE, Vol. 7, N° 4 (10-11-12/2004)

[article]  inIFSCC MAGAZINE > Vol. 7, N° 4 (10-11-12/2004) Titre : Cutaneous restructuration by apple seed phytosterols : from DNA chip analysis to morphological alteration Type de document : texte imprimé Auteurs : Thomas Doering, Auteur ; Olaf Holtkötter, Auteur ; Kordula Schlotmann, Auteur ; Claudia Jassoy, Auteur ; Dirk Petersohn, Auteur ; Armin Wadle, Auteur ; Marianne Waldmann-Laue, Auteur Année de publication : 2004 Note générale : Bibliogr. Langues : Anglais (eng) Tags : 'Skin  equivalent'  'cDNA  microarray'  'hyaluronic  acid'  phytosterols  'anti-wrinkle'  'skin  elasticity' Index. décimale : 668.5 Parfums et cosmétiques Résumé : Plant secondary metabolites such as flavonoids, isoflavones and phytosterols have been proposed as cosmetic ingredients displaying anti-aging effects. On the cellular level, however, the activity profiles of these ingredients are only partially understood. In this study we analyzed the effects of apple seed phytosterols on age-related structural and functional parameters using cell biochemical, molecular biological and bioengineering techniques. The expression of age-related genes was studied using skin equivalents and cDNA microarrays. Incubation of skin equivalents with apple seed phytosterols had significant consequences: (i) differential regulation of a set of genes associated with keratinocyte proliferation and differentiation, (ii) stimulation of hyaluronic acid synthesis, and (iii) increase of epidermal thickness. In vivo studies revealed that apple seed phytosterols improve skin elasticity and decrease skin roughness. In conclusion, apple seed phytosterols display distinct biological effects and significantly improve the structure and function of mature skin. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10481 [article]

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Super mild oxidation coloring : preventing hair damage at the molecular level / Thomas Doering in IFSCC MAGAZINE, Vol. 10, N° 4 (10-11-12/2007)

[article]  inIFSCC MAGAZINE > Vol. 10, N° 4 (10-11-12/2007) . - p. 323-329 Titre : Super mild oxidation coloring : preventing hair damage at the molecular level Type de document : texte imprimé Auteurs : Thomas Doering, Auteur ; Claudia Brockmann, Auteur ; Armin Wadle, Auteur ; Detlef Hollenberg, Auteur ; Thomas Förster, Auteur Année de publication : 2008 Article en page(s) : p. 323-329 Note générale : Bibliogr. Langues : Anglais (eng) Tags : 'Acide  alpha  lipoique'  'Anti-oxydant'  'Cheveux  abimés'  'Colorant  pour  cheveux'  'Spectroscopie  infrarouge  proche' Index. décimale : 668.5 Parfums et cosmétiques Résumé : Hydrogen peroxide is widely used for oxidation hair coloring or bleaching. It displays a high redox potential and easily penetrates into the hair fiber. This renders hydrogen peroxide capable of non-specific interactions with cortex and cuticle proteins resulting in irreversible cleavage of cystine crosslinks. Various classes of antioxidants were screened for their anti-hair damage effect in a permanent hair dye formulation using NIR spectroscopy. In parallel, the effect on the coloring and lightening performance was studied to exclude unwanted side effects on primary product performance. The screening criteria were fulfilled by organic disulfides such as α-lipoic acid but interestingly not by powerful antioxidants such as tocoperol, dibutylhydroxytoluene, or beta-carotene. Alpha-lipoic acid significantly protected human hair during oxidation coloring as demonstrated by (i) amino acid and protein analysis, (ii) surface polarity measurement, (iii) lipid analysis, (iv) differential scanning calorimetry, and (v) combing work measurement. Our results show that radical scavenging properties alone do not render antioxidants suitable for hair protection during oxidative treatments. The presence of disulfide bonds appears to be very favorable and it is likely that the intramolecular cross-link within α-lipoic acid provides a kinetically controlled protection for cystine crosslinks during oxidation coloring. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10417 [article]

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