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Technological strategies to improve photostability of a sunscreen agent / Paola Perugini in IFSCC MAGAZINE, Vol. 8, N° 4 (10-11-12/2005)
[article]
Titre : Technological strategies to improve photostability of a sunscreen agent Type de document : texte imprimé Auteurs : Paola Perugini, Auteur ; Manuela Vettor, Auteur ; Rosanna Tursilli, Auteur ; Santo Scalia, Auteur ; Ida Genta, Auteur ; Tiziana Modena, Auteur ; Franca Pavanetto, Auteur ; Bice Conti, Auteur Année de publication : 2005 Article en page(s) : p. 301-305 Note générale : Bibliogr. Langues : Anglais (eng) Tags : 'Produits de protection solaire' 'Photodégradation d'agent '2-éthylhexyl-p-méthoxycinnamate' Nanoparticules Index. décimale : 668.5 Parfums et cosmétiques Résumé : Due to the reduction of the ozone layer, there is an increasing need of effective UV protection systems with minimised side-effects. Trans-2-ethylhexyl-p-methoxycinnamate (trans-EHMC) represents one of the most widely used sunscreen compound. Several studies demonstrated that trans-EHMC is unstable following UV irradiation both in solution and in emulsion formulations. Moreover, various reports of photocontact sensitization induced by trans-EHMC have appeared in the literature. Consequently, in order to ensure adequate efficacy and safety for this sunscreen agent, there is a need for new carrier systems to enhance trans-EHMC photostability. In the present study the photostability of the filter in different formulation types (emulsion-gel, gel and emulsion) with various ingredients is evaluated. In addition, nanoparticles based on poly-D,L-lactide-co-glycolide (PLGA) as carrier for trans-EHMC are investigated. The influence of nanoparticle matrix on the photochemical stability of the sunscreen agent is also presented. The results obtained demonstrated that PLGA nanoparticles are effective in reducing the light-induced degradation of the sunscreen agent. Moreover, the choice of formulation type and the excipients used play an important role in order to obtain a stable cosmetic product containing trans-EHMC. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10453
in IFSCC MAGAZINE > Vol. 8, N° 4 (10-11-12/2005) . - p. 301-305[article]Réservation
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Code-barres Cote Support Localisation Section Disponibilité 003889 - Périodique Bibliothèque principale Documentaires Disponible The application of mixed micelle theory to personal care ingredients / John Gormley in IFSCC MAGAZINE, Vol. 6, N° 2 (04-05-06/2003)
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Titre : The application of mixed micelle theory to personal care ingredients Type de document : texte imprimé Auteurs : John Gormley, Auteur ; Chris Cook, Auteur Année de publication : 2003 Article en page(s) : p. 133-138 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Concentration micellaire critique
Micelles
Parabènes
Produits de toilette
SurfactantsTags : 'Synergie d'agent tensio-actif' 'Théorie régulière de solution' 'Compteur-irritation' 'Nettoyage doux' 'Efficacité des parabens' Index. décimale : 668.5 Parfums et cosmétiques Résumé : Specific surfactant blends may contribute to reduce irritation by synergistically lowering the critical micelle concentration (CMC)and the monomer level of the more irritating surfactant in bulk solution. A computer program was made and used to calculate molecular interaction parameters (beta) using the widely accepted regular solution theory. This information allowed for the prediction of monomer levels at and above the CMC in mixed surfactant solutions having known CMC values. Such information is included for a series of amphoteric surfactants interacting with SLES-2 at pH 7 and ranked according to their efficiency in lowering the free anionic monomer content in the bulk phase. There is strong debate over whether a correlation truly exists between skin irritancy and CMC techniques. This technique and software provide part of the data set that can help support of refuse such a correlation.
This technique was also used to prescreen a developmental non-ionic surfactant for counter-irritancy with C14-16 alpha olefin sulfonates. The test surfactant was found to lack synergy with the anionic mixture, thus predicting that it would not be a milder system. This prescreening prevented testing this system on humans or animals.
The model was extended to calculate the interaction of Polysorbate-20 with propylparaben. The free active level(ex-micelle) of preservative was calculated as a function of total amount of preservative added. A strong interaction reduced the unbound propylparaben concentration such that anti-microbial activity was lost.Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10604
in IFSCC MAGAZINE > Vol. 6, N° 2 (04-05-06/2003) . - p. 133-138[article]Réservation
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Code-barres Cote Support Localisation Section Disponibilité 003879 - Périodique Bibliothèque principale Documentaires Disponible