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Senolytics : Eliminating senescent cells / Julia Baumann in GLOBAL PERSONAL CARE, Vol. 23, N° 1 (01/2022)
[article]
Titre : Senolytics : Eliminating senescent cells Type de document : texte imprimé Auteurs : Julia Baumann, Auteur ; Franziska Wandrey, Auteur ; Fred Zülli, Auteur Année de publication : 2022 Article en page(s) : p. 35-37 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Anti-inflammatoires
Cuir chevelu -- Soins et hygiène
Dermo-cosmétologie
Extraits de plantes:Extraits (pharmacie)
SénolyseIndex. décimale : 668.5 Parfums et cosmétiques Résumé : Cellular senescence, a condition of irreversible cell cycle arrest, can lead to inflammation and accelerated ageing of tissues, including the skin. To prevent this, current strategies aim specifically to eliminate the senescent cells, or ‘zombie cells’, by means of senolytics. Sensitive scalps are a prominent problem and one potential treatment option is the use of senolytics in scalp care. As with the skin, zombie cells in the scalp can cause local inflammation, leading to dry and irritated scalps, so clearing these cells could promote a healthy scalp. An extract from the leaves of the Swiss Alpine rose was found to have strong senolytic activity in fibroblasts. In a placebo-controlled clinical study, the extract further demonstrated a significant soothing effect on sensitive scalps. This study firstly highlights the positive impact of senolytics in scalp health and care. Note de contenu : - Nature' senolytic
- Sensitive scalps : A common problem
- Methods
- Results a discussion
- Scalp redness & itchingEn ligne : https://drive.google.com/file/d/1Fc4-mpR4S9dqy4i40gj4q0-vwYFPEzU_/view?usp=drive [...] Format de la ressource électronique : Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=37087
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Code-barres Cote Support Localisation Section Disponibilité 23094 - Périodique Bibliothèque principale Documentaires Disponible Stem cell activation for a V-shaped face / Franziska Wandrey in PERSONAL CARE EUROPE, Vol. 13, N° 3 (04/2019)
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Titre : Stem cell activation for a V-shaped face Type de document : texte imprimé Auteurs : Franziska Wandrey, Auteur ; Daniel Schmid, Auteur ; Fred Zülli, Auteur Année de publication : 2019 Article en page(s) : p. 35-38 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge
Antiâge:Antirides
Dermo-cosmétologie
Extraits de plantes:Extraits (pharmacie)
Peau -- Soins et hygièneIndex. décimale : 668.5 Parfums et cosmétiques Résumé : As we age, the production of collagen and elastin is reduced, which results in sagging skin that can most notably be observed at the face contours of the jawline. Mesenchymal stem cells have been shown to improve collagen productionsand regenerate the skin, for example during wound healing. These processes are mediated by vesicles known as exosomes which are produced and secreted by these stem cells. A novel active ingredient based on goji plant stem cells was shown to improve the stemness of aged mesenchymal stem cells as well as increase exosome signalling by mesenchymal stem cells, which in turn improves extracellular matrix production in fibroblasts. The improved extracellular matrix rejuvenates the skin by improving skin density, reducing wrinkles and reshaping the face for an improved V-shape of the face Note de contenu : - Cell-to-cell communication via exosomes
- Goji - the superfruit
- Producing plant stem celle
- MATERIALS AND METHODS : Expression of stem cell markers in age MSCs - Quantification of exosome production by MSCs - Gene expression in fibroblasts after treatment with MSC-conditioned medium - Clinical study on photoaged skin - Skin study on oval face shape
- RESULTS AND DISCUSSION : Maintenance of stemness in aged MSCs - Increase in MSC exosome production - Stimulation of extracellular matrix genes through cell-to-cell communication - Improvement of wrinkle depth and skin density in photoaged skin - Improvement of the oval face shape
- Fig. 1 : Schematic illustration of exosome signalling between mesenchyma stem cells and fibroblasts
- Fig. 2 : Increase in stem cell marker expression in aged mesenchymal stem cells after treatment with goji stem cell extract
- Fig. 3 : Increase in exosome production by mesenchymal stem cells after treatment with goji stem cell extract
- Fig. 4 : Gene expression of extracellular matrix genes by fibroblasts treated by conditioned medium for either untreated or goji stem cell extract treated mesenchymal stem cells
- Fig. 5 : Increase in epidermis + dermis density after 28 days treatment with 0.4 % goji stem cell active
- Fig. 6 : Representative ultrasound image of the increase in epidermis + dermis density after 28 days treatment with 0.4 % goji stem cell active. SLEB = subepidermal low-echogenic band
- Fig. 7 : Decrease in wrinkle depth on crow's feet after 56 days treatment with 0.4 % goji stem cell active
- Fig. 8 : Representative before/after pictures of two volunteers to illustrate the decrease in wrinkle depth on crow's feet after 56 days treatment with 0.4 % goji stem cell active
- Fig. 9 : Improvement of oval face shape after 28 days treatment with 0.4 % goji stem cell active
- Fig. 10 : Visibly improved V-shape of the face after 28 days treatment with 0.4 % goji stem cell activeEn ligne : https://drive.google.com/file/d/1w9R1CQkBtghzvjHrou4HlI_jaPJoXpPY/view?usp=drive [...] Format de la ressource électronique : Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=32231
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Code-barres Cote Support Localisation Section Disponibilité 20796 - Périodique Bibliothèque principale Documentaires Disponible Stimulating endorphins and sex hormones in the skin / Daniel Schmid in PERSONAL CARE EUROPE, Vol. 11, N° 4 (09/2017)
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Titre : Stimulating endorphins and sex hormones in the skin Type de document : texte imprimé Auteurs : Daniel Schmid, Auteur ; Franziska Wandrey, Auteur ; Fred Zülli, Auteur Année de publication : 2017 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Dermo-cosmétologie
Endorphines
Hormones sexuelles
Peau -- Soins et hygiène
Poivres et constituantsIndex. décimale : 668.5 Parfums et cosmétiques Résumé : The peptide hormone beta-endorphin and the steroid hormone
dehydroepiandrosterone (DHEA) play important roles in the skin. The fast that they are aise synthesised locally in the skin makes them interesting targets for cosmetic ingredients. An extract of monk's pepper (Vitex agnus-castus) was found to perform like beta-endorphin and to stimulate the synthesis of DHEA. In a clinical study, the extract showed significant effects on skin elasticity and density.Note de contenu : - Fig. 1. Competition between beta-endorphin and an extract of Vtex agnus-castus in binding to opioid receptors. The smaller the indicated IC50-values (µg/ml) the stronger the brinding of the extract to the receptor
- Fig. 2. The biosynthesis of the sex hormones from the cholesterol precursor
- Fig. 3. Stimulation of the synthesis of DHEA and androstenedione by the monk's pepper extract at 0,1 %
- Fig. 4. Improvement of skin elasticity after four weeks of treatment witha cream containing 2% monk's pepper ingredient
- Fig. 5. Ultrasonographic images of the forearm of a volunteer before and after tratment. Colour scale : white - yellow - red - green - blue - black ; light colours indicating high echogenicity and thus high skin densityEn ligne : https://drive.google.com/file/d/1ikZrRzzU5gqSEH9mXZsZ2PPLAJIK9KnU/view?usp=drive [...] Format de la ressource électronique : Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=29330
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Code-barres Cote Support Localisation Section Disponibilité 19098 - Périodique Bibliothèque principale Documentaires Disponible A Swiss glacier bacterium to vitalize tired skin / Christina Pickel in SOFW JOURNAL, Vol. 146, N° 3 (03/2020)
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Titre : A Swiss glacier bacterium to vitalize tired skin Type de document : texte imprimé Auteurs : Christina Pickel, Auteur ; Franziska Wandrey, Auteur ; Daniel Schmid, Auteur ; Bernhard Henes, Auteur ; Fred Zülli, Auteur Année de publication : 2020 Article en page(s) : p. 2-7 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Actifs anti-fatigue (cosmétique)
Antiâge:Antirides
Bactéries
Cosmétiques
Dermo-cosmétologie
Extraits de plantes:Extraits (pharmacie)
Fibroblastes
Molécules chaperonnes
Peau -- Soins et hygièneIndex. décimale : 668.5 Parfums et cosmétiques Résumé : Today’s society is characterized by demanding jobs, long working hours and an increasingly hectic lifestyle, which frequently results in a lack of sleep. This is often markedly reflected of the skin by a tired appearance of the face. Recent research showed that also on the molecular level, lack of sleep causes stress and leads to premature aging. A major stress mechanism, the unfolded protein response (UPR) of the endoplasmic reticulum (ER), gets compromised by sleep deprivation, leading to the accumulation of misfolded proteins which damage the cell. To target this novel cellular aging mechanism, an extract of the psychrotolerant Swiss glacier bacterium Iodobacter ssp. was developed and analyzed for its efficacy to reduce ER stress and visible signs of tiredness. Treatment of aged fibroblasts with the extract led to an increase in the expression of ER chaperones which mediate the UPR and energized cells through an increase of ATP levels in a cellular model of sleep deprivation. Placebo-controlled randomized clinical studies conducted with sleep-deprived and overworked volunteers demonstrated that treatment with the Iodobacter-derived active ingredient IceAwakeâ„¢ improved several skin parameters associated with skin aging, leading to a vitalized and rejuvenated appearance. Note de contenu : - INTRODUCTION : Lack of sleep impacts on the cellular stress response - Harnessing the potential of extremophile organisms - A freshness kick for tired skin with a swiss glacier bacterium
- METHODS AND RESULTS : Iodobacter ssp. extract re-activates chaperone expression in aged fibroblasts - ER stress is reduced by iodobacter ssp. extract in a cellular model of sleep deprivation - IceAwakeTM ameliorate visible signs of tiredness in mixed study population
- Fig. 1 : Gene expression of chaperone genes in aged fibroblasts treated with Iodobacter ssp. extract relative to untreated cells
- Fig. 2 : ATP levels in AD fibroblasts upon treatment with Iodobacter ssp. extract relative to untreated cells
- Fig. 3 : Quantification of MAM contact points in healthy cells or AD fibroblasts treated with the Iodobacter active or left untreated
- Fig. 4 : Immunofluorescence staining of MAM contact points in healthy cells or AD fibroblasts treated with the Iodobacter active or left untreated
- Fig. 5 : Decrease of wrinkle depth upon treatment with IceAwakeâ„¢
- Fig. 6 : Reduction of tired appearance upon treatment with IceAwakeâ„¢
- Fig. 7 : Visible improvement of wrinkle depth and dark circles with IceAwakeâ„¢
- Fig. 8 : Increase in radiance with IceAwake™En ligne : https://drive.google.com/file/d/1loBLI9V-EftSW37JaxNslSg-kvYiOCzi/view?usp=drive [...] Format de la ressource électronique : Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=33820
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Code-barres Cote Support Localisation Section Disponibilité 21589 - Périodique Bibliothèque principale Documentaires Disponible