Anti-Inflammatory Activity of Pseudopterosins by Laser Doppler Blood Flow Evaluation / Nava Dayan in IFSCC MAGAZINE, Vol. 12, N° 1 (01-02-03/2009)

[article]  inIFSCC MAGAZINE > Vol. 12, N° 1 (01-02-03/2009) . - p. 17-22 Titre : Anti-Inflammatory Activity of Pseudopterosins by Laser Doppler Blood Flow Evaluation Type de document : texte imprimé Auteurs : Nava Dayan, Auteur ; Gary Grove, Auteur ; Rajarajeswari Sivalenka, Auteur Année de publication : 2009 Article en page(s) : p. 17-22 Note générale : Bibliogr. Langues : Anglais (eng) Tags : Anti-inflammatory  Clinical  study  Laser  doppler  blood  flowmetry  Pseudopterosins Index. décimale : 668.5 Parfums et cosmétiques Résumé : Pseudopterosins extracted from Caribbean Sea Whip (Pseudopterogorgia elisabethae) were previously shown to inhibit phospholipase A2, an enzyme that functions in the arachidonic acid cascade of inflammation. With an objective to test its in vivo anti-inflammatory potential, we conducted a screening clinical bioassay using randomized analysis on sixteen panelists. An emulsion containing 0.02% of sea whip extract was applied to the volar forearm of subjects prior to or after an ethyl nicotinate challenge. Blood flow rate at the application site monitored using a laser doppler blood flowmeter served as a measure of inflammation induced by ethyl nicotinate. Upon post-challenge treatment, sea whip extract reduced blood flow by 35.04% against untreated control and also delayed the blood flow. More pronounced reduction in blood flow, as low as 59.50%, was noted upon pretreatment. This reduction was significant (p < 0.0095). Pretreatment caused not only a delay in onset of inflammation but also a reduction in the peak time of blood flow. This study further substantiates the previously reported in vitro anti-inflammatory effect of sea whip extract, demonstrating its activity in deep skin layers by affecting blood flow. The preventive application prior to induction of inflammation was more effective when compared to post-treatment. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=4773 [article]

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A practical clinical device for evaluating changes to the skin's sebum from ozone / Frank Liebel in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 46, N° 4 (08/2024)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 46, N° 4 (08/2024) . - p. 598-602 Titre : A practical clinical device for evaluating changes to the skin's sebum from ozone Type de document : texte imprimé Auteurs : Frank Liebel, Auteur ; Stephanie Petersen, Auteur ; Gary Grove, Auteur ; Tim Houser, Auteur Année de publication : 2024 Article en page(s) : p. 598-602 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Cosmétiques Dermo-cosmétologie Ozone Peau -- analyse Peau -- Effets de la pollution atmosphérique Peau -- Soins et hygiène Sébum Squalène Index. décimale : 668.5 Parfums et cosmétiques Résumé : - BACKGROUND : It is known that tropospheric ozone (O3) generated from pollutants reacting with UV forms lipid peroxidation products and induces oxidative stress to the skin. With the ever-increasing consumer awareness of the effects pollution has on skin, more testing methods will be needed to evaluate cosmetic ingredients. Recently, others have shown how antioxidants are able to reduce the effects from ozone on skin through in vitro, ex vivo and clinical studies where human subjects place their arms into large stationary chambers. - OBJECTIVE : To develop a small, easy to use ozone exposure module (OEM) that can be used on various sites of the body and to validate this device for use in testing the ability of topical products to mitigate the effects of ozone exposure on the skin. - MATERIALS AND METHODS : We have produced an OEM which can generate levels of ozone in excess of 1000 ppb and can be set to achieve the equivalent exposure to what is found in polluted environmental conditions. After exposure we used D-squame discs to remove the sebum and analytically quantitate squalene depletion. Squalene, which is very sensitive to ROS, easily oxidizes into early metabolite squalene monohydroperoxide (SQOOH) with ozone exposure. - RESULTS : We were able to show decreases in squalene levels after exposure and protective effects from a topical formulation. - CONCLUSION : This generator will be a useful tool for researchers to easily create a small and safe exposure from ozone for clinical testing. Note de contenu : - MATERIALS AND METHODS : Device specifics - In vivo studies - Analytical method for squalene detection from D-Squame tapes - Data analysis - RESULTS AND DISCUSSION : Results - Discussion DOI : https://doi.org/10.1111/ics.12998 En ligne : https://drive.google.com/file/d/1gmXdZ-4YIa3jjn8qbqyWq6SnU25v6W_A/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=41358 [article]

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