Enlarged rete pegs with excessive accumulation of melanosomes leading to darker aging spots revealed by histomorphological measurements of internal structures of the epidermis / Tatsuo Yamamura in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 45, N° 3 (06/2023)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 45, N° 3 (06/2023) . - p. 387-399 Titre : Enlarged rete pegs with excessive accumulation of melanosomes leading to darker aging spots revealed by histomorphological measurements of internal structures of the epidermis Type de document : document électronique Auteurs : Tatsuo Yamamura, Auteur ; Soko Kobayashi, Auteur ; Ikuyo Yoshida, Auteur ; Ken-ichi Kuriyama, Auteur Année de publication : 2023 Article en page(s) : p. 387-399 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Cellules basales Chevilles de rete Les chevilles de rete (également appelées processus de rete ou crêtes de rete ) sont les extensions épithéliales qui se projettent dans le tissu conjonctif sous-jacent de la peau et des muqueuses. Épithélium cutané (violet) avec lamina propria (tissu conjonctif sous-jacent) (rose) - l'épithélium présente des chevilles rete. Les chevilles Rete protègent le tissu contre le cisaillement. Dans l'épithélium de la bouche, la gencive attachée présente des rete pegs, contrairement aux épithéliums sulculaire et jonctionnel. Le tissu cicatriciel manque de chevilles et les cicatrices ont tendance à se cisailler plus facilement que les tissus normaux. Aussi connues sous le nom de papilles, ce sont des épaississements vers le bas de l'épiderme entre les papilles dermiques. (Wikipedia) Dermatologie Mélanosome Microscopie confocale à balayage laser Peau -- Physiologie Taches pigmentaires (dermatologie) Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Various histological studies of facial pigmented spot sites such as solar lentigo have been reported, but few studies have used quantitative indices by histomorphometric analysis of the internal structure of pigmented spot sites using non-invasive methods. In the present study, to quantitatively elucidate morphological changes in the epidermis in male, darker-pigmented spots and female, light-pigmented spots, indices that characterize the internal structure of the epidermis in pigmented spot sites were measured using in vivo confocal laser scanning microscopy (CLSM). - Methods : The darkness of pigmented spots on the cheeks of 69 women and 43 men was analysed using image analysis software. The L* value was calculated from RGB values obtained from facial images. The internal structures of pigmented spots on the cheeks of 13 subjects were observed by CLSM. Various parameters were measured using CLSM images from the surface of the stratum corneum to the bottom of the dermal papillae, including the thickness of the epidermis, melanosome content, and shape of the dermal papillae. - Results : Mean ΔL* values between pigmented spots and non-pigmented areas of male subjects were significantly increased in the 40s and 50s compared with those of female subjects. Conspicuous pigmented spots increased in the 40s in male subjects and the 50s in female subjects. In CLSM observations, significant increases in the thickness of the epidermis and melanosome content were confirmed in pigmented spots compared with surrounding non-pigmented areas. In particular, melanosome content in the male subject group with dark-coloured pigmented spots increased significantly to about eight times that of non-pigmented areas, and more than double that of the male subject group with light-coloured pigmented spots. - Conclusion : From the measurements of quantitative parameters, morphological changes in the epidermis were clearly related to the surface colour tone of pigmented spots. Darker pigmented spot sites tended to show longer rete pegs in the epidermis. Accumulation of melanosomes in epidermal basal cells could be considered to increase with the degree of elongation of rete pegs at pigmented spot sites and, thus, induce darker pigmented spots. Note de contenu : - Darkness of pigmented spots - Classification of pigmented spots by facial images - In vivo confocal laser scanning microscopy imagin - Image analysis - Plasmin-like activity measurement - Table 1 : Skin internal structure parameters of pigmented spot sites DOI : https://doi.org/10.1111/ics.12846 En ligne : https://drive.google.com/file/d/1N7kURDEzzTsv7rwPy1lezdamlIsgqbi6/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=39569 [article]

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