5-a reductase inhibition by Epilobioum fleischeri extract modulates facial microbiota structure / Riccardo Sfriso in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 44, N° 4 (08/2022)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 44, N° 4 (08/2022) . - p. 440-452 Titre : 5-a reductase inhibition by Epilobioum fleischeri extract modulates facial microbiota structure Type de document : document électronique Auteurs : Riccardo Sfriso, Auteur ; Joshua Claypool, Auteur ; Magalie Roche, Auteur ; Dominik Imfeld, Auteur Année de publication : 2022 Article en page(s) : p. 440-452 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antienzymes Extraits de plantes:Extraits (pharmacie) Formulation (Génie chimique) Justification de l'allégation Microbiome cutané Microbiote cutané Peau -- Soins et hygiène Réductase Une réductase est une enzyme qui diminue l'énergie d'activation d'une réaction d'oxydo-réduction. (Wikipedia) Visage -- Soins et hygiène Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Background : Facial skin is a particularly complex environment made of different skin types such as sebaceous (forehead) and dry (cheeks). The skin microbiota composition on different facial sites has not yet been addressed. - Methods : We conducted a 4-week-long, single-centre, randomized and placebo-controlled clinical study involving 23 Caucasian females. We assessed both bacterial composition on five different facial areas and the microbiome modulatory effects resulting from the topical application of a plant extract (Epilobium fleischeri). Skin microbiome samples were collected before and after 4 weeks of product application. Microbiota profiling was performed via 16S rRNA gene sequencing, and relative abundance data were used to calculate differentials via a multinomial regression model. - Results : Via ‘reference frames’, we observed shifts in microbial composition after 4 weeks of twice-daily product application and identify certain microbiota species, which were positively associated with the application of the product containing the Epilobium fleischeri extract. Staphylococcus hominis, Staphylococcus epidermidis, and Micrococcus yunnanensis appeared to be significantly enriched in the final microbiota composition of the active treatment group. - Conclusion : Facial skin was found to be colonized by an heterogenous microbiota, and the Epilobium fleischeri extract had a modulatory effect on commensal bacteria on the different facial sites. Note de contenu : - INTRODUCTION : Objectives - MATERIALS AND METHODS : Test formulations - Clinical study design - Porphyrins Non-inflammatory lesions Skin microbiome sampling 16S rRNA gene sequencing and predicted metagenomics Data filtering and analysis Facial colour mapping RESULTS Relative abundance and diversity Reference frames and differential ranking Porphyrins and non-inflammatory lesions assessment - Table 1 : Formulations used in the clinical study - Table 2 : Songbird output values for pathways related to N-acetylneuraminate degradation, mandelate degradation, hexitol degradation and tryptophan degradation DOI : https://doi.org/10.1111/ics.12777 En ligne : https://drive.google.com/file/d/1O4avryVbmE2KCmKDwKdGIKdskdHRNMHU/view?usp=shari [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=38144 [article]

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Sunscreens can preserve human skin microbiome upon erythemal UV exposure / Rolf Schuetz in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 46, N° 1 (02/2024)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 46, N° 1 (02/2024) . - p. 71-84 Titre : Sunscreens can preserve human skin microbiome upon erythemal UV exposure Type de document : texte imprimé Auteurs : Rolf Schuetz, Auteur ; Joshua Claypool, Auteur ; Riccardo Sfriso, Auteur ; Vollhardt Juergen H., Auteur Année de publication : 2024 Article en page(s) : p. 71-84 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Cosmétiques Dermo-cosmétologie Etudes cliniques Justification de l'allégation Microbiologie Microbiote cutané Peau -- Anatomie Peau -- Physiologie Peau -- Soins et hygiène Peau noire -- Physiologie Produits antisolaires Protection contre le rayonnement ultraviolet Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Ultraviolet radiation (UVR) is a known environmental key factor for premature skin ageing. Only few scientific evidence is available to support the effects of UVR on the skin microbiome. This in vivo pilot study aimed to evaluate the impact on the skin microbiome upon erythemal UV exposure and the protection of UV-exposed skin microbiome by UV filters. - Methods : Ten female volunteers were treated with an sun protection factor (SPF) 20 sunscreen and placebo formulation (without UV filters) on their upper middle backs and irradiated with an erythemal dose (2 MED) by a solar simulator. Skin swabbing samples from four zones (i.e., unexposed, exposed, sunscreen- and placebo-treated on exposed skin) were collected for the microbiome analysis before and 2 h after UV exposure, respectively, and processed via shallow 16S rRNA Amplicon and Shotgun metagenomic sequencing. An in vitro UV method was developed to confirm the protection of isolated bacterial strains by single UV filters and combinations. - Results : Alpha diversity was impacted by significant inter-individual differences and by treatment rather than by irradiation. Cutibacterium acnes was found to be the most abundant and a confounding factor for diversity. On a species level, Lactobacillus crispatus was negatively associated with UVR and placebo treatment, whereas there was a positive association with sunscreen treatment. The sunscreen treatment also favoured an interaction network with central Micrococcus genus. The in vitro results showed that both single UV filters and combinations had specific effects on the survival rates of L. crispatus, C. acnes, and Staphylococcus epidermidis. - Conclusion : We identified potential microorganisms and bacterial interactions that were associated with an SPF 20 sunscreen treatment. The specific protection of L. crispatus as a key player in the UV-exposed skin microbiome and reduction of C. acnes population by UV filters might lead to new cosmetic concepts for photoprotection. Note de contenu : - METHODS : Clinical test products - Human study design - Skin microbiome sampling - DNA extraction - 16S rRNA amplicon sequencing - Illumina shotgun sequencing and data processing - Alignment-based filtering (Illumina) - Canonical correspondence analysis (CCA) - Songbird - Spiec-Easi : Microbial interactions - In vitro UV model - RESULTS AND DISCUSSION : Clinical study results - 16S sequencing results - Diversity - Differential ranking analysis - Interaction network - Metagenomics - In vitro UV model with isolated bacteria DOI : https://doi.org/10.1111/ics.12910 En ligne : https://drive.google.com/file/d/17ySV5EMMh2OIbzqRLOQowy6BGvVyGcWk/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=40580 [article]

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