Anti-inflammatory and scalp care efficacy of a multi-herb extraction against malassezia furfur / Yina Lu in SOFW JOURNAL, Vol. 147, N° 11 (11/2021)  

[article]  inSOFW JOURNAL > Vol. 147, N° 11 (11/2021) . - p. 6-11 Titre : Anti-inflammatory and scalp care efficacy of a multi-herb extraction against malassezia furfur Type de document : texte imprimé Auteurs : Yina Lu, Auteur ; Jun Tian, Auteur Année de publication : 2021 Article en page(s) : p. 6-11 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Anti-inflammatoires Biomolécules actives Cosmétiques Cuir chevelu -- Soins et hygiène Dermatite sébhorrhéique Dermatites fongiques Dermo-cosmétologie Eczéma constitutionnel Essais (technologie) Malassezia Index. décimale : 668.5 Parfums et cosmétiques Résumé :  Malassezia furfur is a lipophilic and dermatological pathogenic yeast, which normally exists on human skin, and causes tinea versicolor, seborrhoeic dermatitis, and atopic dermatitis, especially on human scalp. The multi-herb extraction VGP which consists of Vitex trifolia fruit, Gentiana scabra, and Polygonum multiflorum root extract was used to study its effect of anti-inflammation, controlling sebum and dandruff on scalp care. Results showed that on the model of NHEK and THP1 cell inflammation induced by Malassezia furfur, VGP can inhibit the expression of interleukin 6 (IL-6), prostaglandin E2 (PGE-2), monocyte chemoattractant protein 1 (MCP-1) and interleukin 1β (IL-1β) in a dose-dependent manner under 0.01% to 0.125% concentration. On the inflammatory model of 3D reconstructed skin induced by H2O2, VGP significantly improved the cell viability and skin structure, and reduced the production of interleukin 8 (IL-8), PGE-2, and leukotriene B4 (LTB4). During 4 week’s treatment with test shampoo contained 0.5% VGP thrice a week on 16 subjects met with different symptom, VGP reduced the sebum content and TEWL, improved the redness, itching and dandruff on human scalp skin. Therefore, as a natural active ingredient VGP can play a role in scalp care and skin care by targeting inflammation. Note de contenu : - MATERIALS AND METHODS : VGP preparation - Maintenance of cells - Anti-inflammatory experiments on cells - Anti-inflammatory experiments on 3D reconstructed skin - Scalp care test in vivo - Statistical analysis - RESULTS : Anti-inflammatory efficacy of VGP against M. furfur on cells - VGP inhibited the inflammation and cell damage on reconstructed skin - VGP reduced the itching and redness of human scalp skin En ligne : https://drive.google.com/file/d/1fHsMXBQzG3UwovFof_wsjz_WoYMRYdbR/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=36987 [article]

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Inhibition of lipogenesis and sebum secretion for Lotus corniculatus seed extract in vitro and in vivo / Lu Cheng in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 45, N° 1 (02/2023)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 45, N° 1 (02/2023) . - p. 62-72 Titre : Inhibition of lipogenesis and sebum secretion for Lotus corniculatus seed extract in vitro and in vivo Type de document : document électronique Auteurs : Lu Cheng, Auteur ; Jingyi Guo, Auteur ; Yina Lu, Auteur Année de publication : 2023 Article en page(s) : p. 62-72 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : 5'-o-rhamnosyluridine Cellules -- Cultures et milieux de culture Cheveux -- Teinture Extraits de plantes:Extraits (pharmacie) Ingrédients cosmétiques Lipogénèse Lotier corniculé Peau -- analyse Peau -- Soins et hygiène Sébocytes Séborrhée Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Background : Botanical ingredients are widely used in hair- and skin-care products. However, few studies have investigated the effectiveness of botanical products on counteracting sebum synthesis and secretion. - Objective : To investigate the composition of Lotus corniculatus seed extract (LC) and its potential inhibition of lipogenesis in SZ95 sebocytes and oily human skin. - Methods : The active components of LC solutions were identified by high-performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR). The in vitro effects of LC were evaluated using SZ95 cells treated with linoleic acid (LA) and dihydrotestosterone (DHT) and incubated with LCs for 24 h and 72 h. Lipogenesis was assessed by Oil Red O and Nile Red staining of the cells. In vivo effects were assessed on 30 subjects with oily skin who were enrolled in a randomized, blank-controlled trial and were treated with LC solution for 6 h and 4 weeks. The skin sebum contents and area on the forehead and cheeks were evaluated using a Sebumeter SM815 and Sebfix sebutape with Visioscan VC98. In addition, VISIA was used to collect half-face photos for analysis. - Results : A novel active molecule, 5′-o-rhamnosyl uridine, was identified in LC. LC exhibited a dose-dependent inhibitory effect on LA and DHT-induced lipid synthesis. When 5% LC was applied for 3 h, the skin sebum contents and area were significantly reduced compared with the vehicle control, with an obvious reduction after 6 h. Continued use of the serum containing 5% LC for 4 weeks resulted in a significant reduction in the skin sebum contents and area. No adverse reactions were reported during the study. - Conclusions : Topical application of LC resulted in an immediate and long-lasting reduction of the sebum contents and area of oily human skin by reducing sebaceous lipogenesis through the LA and DHT pathways. This indicates the potential of LC as a new biological treatment for oily skin. Note de contenu : - MATERIALS AND METHODS : Analysis of LC composition - Cell culture - Cell staining - Clinical research - RESULTS : Active components of LC - Lipogenesis in SZ95 sebocytes - Six-hour oily skin evaluation - Four-week oily skin evaluation - Effects of LC on sebum contents - Effects of LC on sebum area - Effects of LC on skin pores DOI : https://doi.org/10.1111/ics.12823 En ligne : https://drive.google.com/file/d/1-XNRv8JntUaPMXIRk6qIoJuNhEaa11zx/view?usp=share [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=38820 [article]

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Lotus corniculatus extract to inhibit lipogenesis / Lu Cheng in GLOBAL PERSONAL CARE, Vol. 25, N° 3 (03/2024)  

[article]  inGLOBAL PERSONAL CARE > Vol. 25, N° 3 (03/2024) . - p. 78-82 Titre : Lotus corniculatus extract to inhibit lipogenesis Type de document : texte imprimé Auteurs : Lu Cheng, Auteur ; Jingyi Guo, Auteur ; Yina Lu, Auteur Année de publication : 2024 Article en page(s) : p. 78-82 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Dermo-cosmétologie Etudes cliniques Evaluation Extraits de plantes:Extraits (pharmacie) Inhibiteurs (chimie) Lipogénèse Lotus corniculatus Peau -- analyse Peau -- Soins et hygiène Séborrhée Statistiques Index. décimale : 668.5 Parfums et cosmétiques Résumé : Jaka Biotech reveals the findings of a study that indicates the topical use of a Lotus corniculatus seed extract yields clinical benefits in reducing sebum production and enhancing skin pore appearance for individuals with oily skin. The increasing popularity of botanical ingredients in skincare and haircare is attributed to their efficacy and natural origins. However, limited research has focused on the synthesis and secretion of sebum. This study aims to explore the novel composition of Lotus corniculatus seed extract (Smopore LC) and its inhibitory effects on lipogenesis in SZ95 sebocytes. Topical application of Smopore LC resulted in an immediate and long-lasting reduction in sebum content and sebum area on Chinese oily skin, achieved by downregulating sebaceous lipogenesis through the LA and DHT pathway. Smopore LC shows promise as a new botanical ingredient for oily skin. Note de contenu : - MATERIALS AND METHODS : LC composition analysis - Cell culture - Cell staining - CLINICAL RESEARCH : Study design - Research product - Subjects - Six-hour clinical evaluation - Four week clinical evaluation - Statistical analysis - RESULTS : Active composition of LC - Lipogenesis on SZ95 sebocytes - Six-hour oily skin evaluation - Four-week oily skin evaluation En ligne : https://drive.google.com/file/d/1tfwIcxig9pVdEQB3ZFccNe2aq0pPKWcY/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=40898 [article]

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A modified protocol for studying filaggrin degradation using a reconstructed human epidermis model under low and high humidity / Qilong Chen in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 46, N° 3 (06/2024)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 46, N° 3 (06/2024) . - p. 380-390 Titre : A modified protocol for studying filaggrin degradation using a reconstructed human epidermis model under low and high humidity Type de document : texte imprimé Auteurs : Qilong Chen, Auteur ; Ning Wei, Auteur ; Yina Lu, Auteur Année de publication : 2024 Article en page(s) : p. 380-390 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Barrière cutanée Désimination La désimination, aussi nommée citrullination, est une modification post-traductionnelle aux multiples facettes. Elle est impliquée dans de nombreux processus cellulaires physiologiques comme la régulation génique, le développement embryonnaire ou encore la différenciation terminale, mais aussi dans divers mécanismes physiopathologiques liés à des maladies humaines graves, comme la sclérose en plaques ou la polyarthrite rhumatoïde. La désimination, conversion enzymatique dépendante du calcium de peptidyl-arginines en peptidyl- citrullines, entraîne une perte de charge des protéines-substrats, ce qui a des conséquences majeures sur leur conformation, leur stabilité, leurs interactions et donc leurs fonctions. Chez l’homme, il existe cinq isotypes de peptidyl-arginine désiminases présentant une expression tissulaire variable. Ces isotypes sont très homologues et étroitement régulés aux niveaux transcriptionnel et post-transcriptionnel, comme, probablement, par auto-désimination. (Méchin Marie-Claire et al. Médecine/sciences 2011 Vol. 27, p. 49-54) Epiderme reconstruit Filaggrine Protéolyse En biochimie, la protéolyse est la segmentation des protéines en ses fragments de base (acides aminés) via l'hydrolyse catalysée par des enzymes dits "protéolytiques" (protéases ou hydrolases). (Wikipedia) Index. décimale : 668.5 Parfums et cosmétiques Résumé : - BACKGROUND : Filaggrin (FLG) is an essential protein that plays a vital role in maintaining skin barrier function and moisture levels, allowing the skin to adapt to dry environments. However, the precise temporal dynamics of FLG metabolism in the human epidermis remain poorly understood, and suitable tools to study these time-dependent effects are currently lacking. - OBJECTIVE : To investigate the molecular mechanisms and time course of FLG metabolism and skin barrier function under high- and low-humidity conditions, utilizing a reconstructed epidermis model. - METHODS : EpiSkin specimens cultured under humid or dry conditions for varying durations (2–48 h) were compared by assessing FLG degradation and skin barrier formation using immunofluorescence staining and western blotting. - RESULTS : Under conditions of low humidity, the proteolysis of FLG in EpiSkin increased between 4 and 12 h and was accompanied by elevated levels of cysteine–aspartic protease (caspase)-14. The expression of peptidyl arginine deiminase 1 and calpain 1 also increased at 4 h. However, after 24 h, the expression of these three FLG-degrading proteins significantly decreased. Conversely, the levels of pyrrolidone-5-carboxylic acid and urocanic acid initially decreased at 2 h and then increased between 12 and 24 h. Additionally, the expression of skin barrier proteins, such as FLG, transglutaminase 5, loricrin and zonula occludens-1, decreased starting from 12 h. Notably, epidermal cell viability and activity were also inhibited. - CONCLUSION : We propose a reliable and ethical model to study the temporal dynamics of FLG metabolism and its role in skin barrier function. Using a commercially reconstructed epidermis to mimic dry skin formation obviates the need for animal and human testing. Note de contenu : - MATERIALS AND METHODS : EpiSkin culture conditions - Cell viability measurement - Haematoxylin–eosin (HE) and immunofluorescence staining - Quantification of PCA and UCA - Western blotting - Statistical analysis - RESULTS : Low humidity thickens the SC and reduces cell viability in EpiSkin - Low humidity promotes FLG degradation into PCA and UCA - Deimination and proteolysis are involved in FLG degradation - Persistently low humidity reduces skin barrier function DOI : https://doi.org/10.1111/ics.12937 En ligne : https://drive.google.com/file/d/1BofDSqKJx_VeScQCg4XoFfrILKe29b53/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=41340 [article]

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Scalp care efficacy of a multi-herb extract / Yina Lu in GLOBAL PERSONAL CARE, Vol. 22, N° 6 (06/2021)  

[article]  inGLOBAL PERSONAL CARE > Vol. 22, N° 6 (06/2021) . - p. 33-36 Titre : Scalp care efficacy of a multi-herb extract Type de document : texte imprimé Auteurs : Yina Lu, Auteur ; Zhang Heng, Auteur ; Jun Tian, Auteur Année de publication : 2021 Article en page(s) : p. 33-36 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Anti-inflammatoires Cosmétiques Cuir chevelu -- Soins et hygiène Extraits de plantes:Extraits (pharmacie) Malassezia Produits capillaires Statistique Index. décimale : 668.5 Parfums et cosmétiques Résumé : Malassezia furfur is a lipophilic and dermatological pathogenic yeast, which normally exists on human skin, and causes tinea versicolor, seborrhoeic dermatitis, and atopic dermatitis, especially on human scalp. The multi-herb extraction, VGP, which consists of Vitex trifolia fruit, Gentiana scabra, and Polygonum multiflorum root extract was used to study its effect of anti-inflammation, controlling sebum and dandruff on scalp care. Results showed that on the model of NHEK and THP1 cell inflammation induced by Malassezia furfur, VGP can inhibit the expression of interleukin 6 (IL-6), prostaglandin E2 (PGE-2), monocyte chemoattractant protein 1 (MCP-1) and interleukin 1β (IL-1β) in a dose-dependent manner under 0.01% to 0.125% concentration. On the inflammatory model of 3D reconstructed skin induced by H2O2, VGP significantly improved the cell viability and skin structure, and reduced the production of interleukin 8 (IL-8), PGE-2, and leukotriene B4 (LTB4). During 4 week’s treatment with test shampoo containing 0.5% VGP thrice a week on 16 subjects met with different symptoms, VGP reduced the sebum content and TEWL, improved the redness, itching and dandruff on human scalp skin. Therefore, as a natural active ingredient VGP can play a role in scalp care and skin care by targeting inflammation. Note de contenu : - MATERIALS AND METHODS : VGP preparation - Maintenance of cels - Anti-inflammatory experiments on cells - Anti-inflammatory experiments on 3D reconstructed skin - Scalp care test in vivo - Statistical analysis - RESULTS : Anti-inflammatory efficacy of VGP against M. furfur on cells - VGP inhibited the inflammation and cell damage on reconstructed skin - VGP reduced the itching and redness of human scalp skin - Table 1 : Effect of VGP on the viability of two cells - Table 2 : The effect of VGP on scalp redness, dandruff and itching En ligne : https://drive.google.com/file/d/1nlf8RoLehtbFeYtKSvSnZ-81El45gOIT/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=36118 [article]

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