Effectiveness of a formulation containing peptides and vitamin C in treating signs of facial ageing : three clinical studies / S. Escobar in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 43, N° 2 (04/2021)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 43, N° 2 (04/2021) . - p. 131-135 Titre : Effectiveness of a formulation containing peptides and vitamin C in treating signs of facial ageing : three clinical studies Type de document : document électronique Auteurs : S. Escobar, Auteur ; A. Valois, Auteur ; M. Nielsen, Auteur ; Brigitte Closs, Auteur ; D. Kerob, Auteur Année de publication : 2021 Article en page(s) : p. 131-135 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge Barrière cutanée Cosmétiques Formulation (Génie chimique) Peau -- Soins et hygiène Peptides Vitamine C Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Vitamin C and peptides are widely used in cosmetic products but there is a paucity of clinical studies showing that the formulations are effective in treating signs of facial ageing. These 3 clinical studies evaluated the effectiveness of an anti-ageing formula containing natural vitamin C (10%), biopeptides (rice and lupin), hyaluronic acid, and Vichy volcanic mineralising water, in amber glass ampoules with no preservatives (Peptide-C ampoules). - Methods : Dansyl chloride fluorescence labelling compared cell turnover for Peptide-C ampoules vs untreated skin in 32 female subjects. Study 2, an open clinical study, evaluated the efficacy on wrinkles of Peptide-C ampoules by investigator clinical scoring based on Dynamical Atlas visual assessment (N = 40) and subject self-assessment questionnaires (N = 47). Study 3, an open clinical study, evaluated wrinkles by instrumental quantification with 3D fringe projection analysis (N = 40) and subject questionnaires (N = 51). - Results : The mean cell turnover was faster for skin treated with Peptide-C ampoules compared to untreated skin (17.1 days vs. 19.2 days; P < 0.0001). In study 2, after 28 days application of Peptide-C ampoules, clinical grading of crow’s-feet wrinkles, forehead wrinkles and nasolabial folds decreased by 9%, 11% and 5%, respectively (all P < 0.05 vs baseline). Of 47 subjects, 77%, 64% and 79% indicated their skin seemed smoothed out, fine lines were less visible, and skin complexion was more radiant, respectively. In study 3, the number of wrinkles decreased by 11.5% after 29 days application of Peptide-C ampoules vs baseline (P < 0.05) and 65% of subjects responded the fine lines were less visible. - Conclusion : This formulation of a combination of anti-ageing ingredients in ampoules, allowing a minimalist formula, showed significant results on improving facial wrinkles and radiance. Note de contenu : - METHODS : Study 1 : investigator-blinded study with dansyl chloride cell proliferation testing - Study 2 : open study with investigator clinical scoring and subject questionnaires Study 3: open study with instrumental quantification and subject questionnaires - Treatment formulation - Ethical considerations - Statistical analysis - RESULTS : Study 1 : dansyl chloride testing - Study 2 : investigator clinical scoring - Study 3 : instrumental quantification on morphology of wrinkles DOI : https://doi.org/10.1111/ics.12665 En ligne : https://drive.google.com/file/d/18HTF-vxqg4d2pCyRDXWoFdF7xZbCKBPZ/view?usp=shari [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=35751 [article]

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