Biohacking sleep for a restored eye area / Miriam Mateu in GLOBAL PERSONAL CARE, Vol. 22, N° 5 (05/2021)  

[article]  inGLOBAL PERSONAL CARE > Vol. 22, N° 5 (05/2021) . - p. 59-60 Titre : Biohacking sleep for a restored eye area Type de document : texte imprimé Auteurs : Miriam Mateu, Auteur ; Patricia Carulla, Auteur ; M. J. Klein, Auteur ; Ariadna Grau-Campistany, Auteur ; Silvia Pastor, Auteur ; Meritxell Llinas, Auteur Année de publication : 2021 Article en page(s) : p. 59-60 Langues : Anglais (eng) Catégories : Anti-inflammatoires Cernes Contour des yeux -- Soins et hygiène Cosmétiques Dermo-cosmétologie Glycation Peptides Pigmentation, Troubles de la Index. décimale : 668.5 Parfums et cosmétiques Résumé : It is well known that an adequate amount and quality of sleep is key to repairing the damage inflicted to the body during the day. However, it is difficult to really enjoy a regularly undisturbed sleep of 7-9 hours per night. A survey conducted among adults in 13 countries revealed that on average, people sleep 6.8 hours per weeknight and 7.5 hours per weekend night. Hence, the amount of sleep lost during the working week is not compensated over the weekend. Moreover, only 49% of adults are satisfied with their sleep. The recent COVID-19 pandemic has only worsened our sleep quality. Another recent survey among US adults displayed that 98% have developed new sleep problems, and 68% feel it is harder to sleep even after measures were lifted. An additional survey showed that 60% of adults are interested in strategies to sleep better, what is known as biohacking sleep. Note de contenu : - A new tool to 'biohack' sleep - Efficacy studies : Opening the eyes - Attenuation of inflammation - Prevent damage caused by glucose levels - Providing melatonin-like protection - Restoring lymphatic integrity - Capillary de-stressing - Improving hyperpigmentation - Self-assessment - Fig. 1 : Eye-opening effect - Fig. 2 : Efficacy on dark circles - Fig. 3 : Efficacy on hyperpigmentation En ligne : https://drive.google.com/file/d/1RDRoovN5h4MpZK3p6VNSXO-dk_LluOVk/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=35818 [article]

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A new peptide mimicking a good sleep in times of pandemia / Miriam Mateu in SOFW JOURNAL, Vol. 146, N° 12 (12/2020)  

[article]  inSOFW JOURNAL > Vol. 146, N° 12 (12/2020) . - p. 14-19 Titre : A new peptide mimicking a good sleep in times of pandemia Type de document : texte imprimé Auteurs : Miriam Mateu, Auteur ; Patricia Carulla, Auteur ; Marco J. Klein, Auteur ; Ariadna Grau-Campistany, Auteur ; Silvia Pastor, Auteur ; Meritxell Llinas, Auteur Année de publication : 2020 Article en page(s) : p. 14-19 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Glycation Inflammation Interleukines Les interleukines (IL) sont un groupe de cytokines, ainsi nommées car les premières observations semblaient montrer qu'elles étaient exprimées par les globules blancs (leucocytes, d'où -leukin) en guise de moyen de communication (d'où inter-). Les interleukines sont produites par une large variété de tissus et cellules, et que, bien que regroupées sous cette terminologie par commodité, elles ne présentent aucune parenté biochimique ni de fonction entre elles. Elles ont été classées par numéro au gré des découvertes. Au début 2006, 31 cytokines sont connues et dénommées sous l'intitulé IL. La fonction du système immunitaire dépend en grande partie des interleukines et de rares déficiences de certaines d'entre elles ont été décrites, conduisant à des maladies auto-immunes ou des immunodéficiences. Mélatonine Peptides Sommeil Index. décimale : 668.5 Parfums et cosmétiques Résumé : Regularly skipping sleep is associated with chronic low inflammation, oxidative stress and weakened immune system. These three factors are interconnected and all of them generate further inflammation, oxidative stress and worsen the immune system. The alarmin interleukin IL-33 is a pro-inflammatory cytokine released upon cell damage activating the immune response and inducing oxidative stress and further inflammation. IL-33 is over-expressed in conditions of chronic inflammation like a topic dermatitis and obstructive sleep apnea. Sleep disturbance also presents high levels of glucose which may glycate proteins of the skin and the endothelial and lymphatic vessels, weakening their integrity and producing oxidative stress and more inflammation. In addition, melatonin levels are decreased, which not only affects its circadian role but also as a potent antioxidant and antiglycant. iPeptideâ„¢ is a peptide that was discovered to down-regulate IL-33 expression through a Big Data analysis. It showed to modulate chronic inflammation and damages induced by hyperglycemia due to sleep deprivation. It also presented a melatonin-like protection effect and reinforced the first line of immune defense. In vivo, it decreased fatigue features, awakened sleepy lookand had a local cool effect. Note de contenu : - MATERIALS AND METHODS : Gene expression modulation of sleep deprivation – Modulation of IL-33 release – Regulating hyperpigmentation – De-stressing capillarity – Reinforcing lymphatic integrity – Melatonin-like protection against glycation and lipid peroxidatione – Melatonin-like modulation of the epidermal immune protection – Guarding from hyperglycemia damage – Anti-fatigue efficacy in sleep deprived volunteers – Refreshing effect in sleep deprived volunteers - RESULTS AND DISCUSSION : Gene expression modulation of sleep deprivation – Modulation of IL-33 release – Regulating hyperpigmentation – De-stressing capillarity – Reinforcing lymphatic integrity – Melatonin-like protection against glycation and lipid peroxidation – Melatonin-like modulation of the epidermal immune protection – Guarding from hyperglycemia damage – Anti-fatigue efficacy in sleep deprived volunteers – Refreshing effect in sleep deprived volunteers - Fig. 1 : Melatonin-like protection of the peptide against glycationand lipid peroxidation - Fig. 2 : Protection against glycation of human skin explants treated with MGO and non-treated and treated with 0.005 mg/mL ofpeptide. Fibrillin-1 in green - Fig. 3 : Increase of the angle of the eye opening (+21%) in a 59-year-old volunteer before applying a cream with 0.015 mg/m/ of peptide and after 28 days - Fig. 4 : Fatigue features improvement, which is the average of tiredness, dark circles, eyebags and wrinkles - Fig. 5 : Local cooling effect (-0.7°C) in a volunteer of 35 years old before applying a cream with 0.015 mg/mL of peptide and after 28 days - Fig. 6 : Dark circles improvement in a 37-year-old volunteer applying a cream with 0.015 mg/mL of peptide and after one week En ligne : https://drive.google.com/file/d/1mOAQywzRfktLYNaWWiMLmZWyVYXfSm75/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=35002 [article]

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The window to eye beauty : a new "non-gender" eye care active ingredient / Meritxell Llinas in SOFW JOURNAL, Vol. 145, N° 9 (09/2019)  

[article]  inSOFW JOURNAL > Vol. 145, N° 9 (09/2019) . - p. 20-24 Titre : The window to eye beauty : a new "non-gender" eye care active ingredient Type de document : texte imprimé Auteurs : Meritxell Llinas, Auteur ; Elaine Ferreira, Auteur ; Silvia Pastor, Auteur ; Julia A. Boras, Auteur ; Patricia Carulla, Auteur ; Marco J. Klein, Auteur Année de publication : 2019 Article en page(s) : p. 20-24 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Biomolécules actives Contour des yeux -- Soins et hygiène Dermo-cosmétologie Enzymes microbiennes Etudes cliniques Peau -- Soins et hygiène Index. décimale : 668.5 Parfums et cosmétiques Résumé : The skin around the eyes, also known as the periocular area, shows expressions and emotions that are an important part of our personality. One of the first facial areas where visible signs of aging begin to emerge is around the eyes. In fact, the eyes are the focal point of the face and the apparition of bags, dark circles and wrinkles, gives to face a tired appearance and/or make one to look and feel a lot older than she/he really is. We present a new cosmetic Mediterranean active ingredient, Meiviewâ„¢, an exclusive bacterial ferment extract derived from an endophyte Bacillus, found in Mallorca (Spain), living in symbiosis with one of the most salt tolerant halophilic plant (Arthrocnemum macrostachyum). Meiviewâ„¢ presents a broad-spectrum of eye care efficacy. In addition, its efficacy was tested in vivo in women and men volunteers. Note de contenu : - MATERIALS AND METHODS : Gene expression modulation in three types of skin cells - Anticollagenase activity inhibition - Plakoglobin synthesis - Vascular endothelial growth factor (VEFG-A) release - Vascular permeability inhibition and endothelial resistance modulation - Bilirubin degradation - Chelating activity on metal ions (Fe2+) - Melanin synthesis inhibition - Epidermal thickness and collagen/Expression on human skin explants - In vivo efficacy study - RESULTS AND DISCUSSION : Role of the bacillus ferment on the cell-cell adhesion and extracellular matrix maintenance - Role of the bacillus ferment on the vascular fragility and permeability of blood vessels - Role of the bacillus ferment on the accumulation of coloured blood-products and melanin - Clinical instrumental evaluation in the eye contour area En ligne : https://drive.google.com/file/d/1BouMOOEyvHIMnqRLQn6a2tfokV9EjD09/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=33152 [article]

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