Formulation development and characterization of highly water-soluble drug-loaded extended-release pellets prepared by extrusion–spheronization technique / Muhammad Iqbal Nasiri ; Rabia Ismail Yousuf ; Muhammad Harris Shoaib ; Kamran Zaheer ; Tariq Ali ; Kamran Ahmed ; Faaiza Qazia ; Sohail Anwer in JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH, Vol. 16, N° 5 (09/2019)  

[article]  inJOURNAL OF COATINGS TECHNOLOGY AND RESEARCH > Vol. 16, N° 5 (09/2019) . - p. 1351-1365 Titre : Formulation development and characterization of highly water-soluble drug-loaded extended-release pellets prepared by extrusion–spheronization technique Type de document : texte imprimé Auteurs : Muhammad Iqbal Nasiri, Auteur ; Rabia Ismail Yousuf, Auteur ; Muhammad Harris Shoaib, Auteur ; Kamran Zaheer, Auteur ; Tariq Ali, Auteur ; Kamran Ahmed, Auteur ; Faaiza Qazia, Auteur ; Sohail Anwer, Auteur Année de publication : 2019 Article en page(s) : p. 1351-1365 Note générale : Bibliogr. Langues : Américain (ame) Catégories : Ethylcellulose Extrusion sphéronisation Formulation (Génie chimique) Granulés plastiques Hydrochlorure d'itopride Médicaments Système de libération contrôlée (technologie) Index. décimale : 667.9 Revêtements et enduits Résumé : The objectives of current study were (a) to prepare extended-release plain (without polymers) and matrix pellets of itopride hydrochloride (ITP) by extrusion and spheronization technique, (b) to control the initial fast release of drug from the matrix pellets by coating using ethylcellulose, Eudragit® RL/RS100 (2:1), and Kollicoat® SR 30D, and (c) to investigate the influence of different types and concentration of coating polymers on release of highly water-soluble drug. The plain pellet contained microcrystalline cellulose and lactose without polymer, whereas matrix pellet formulations were composed of hydroxypropyl methylcellulose (HPMC K4M, K15M, and K100M) and ethylcellulose (EC 7 cps). Matrix pellet formulations failed to control the drug release, up to targeted period of 12 h. Five pellet formulations—one without polymer (F1) and one from each polymer category (F4, F7, F10, and F13)—were screened out for coating using different types and levels of polymers. The DDSolver (an add-in software for MS Excel) was used to analyze the dissolution profile data for drug release kinetics. However, drug release from pellet formulation (F7) containing HPMC as a matrix former and coated with EC followed zero-order kinetics (R2 = 0.897–0.998). The release mechanism of EC-coated formulations F7, F10, and F13 was non-Fickian diffusion (anomalous transport), whereas F1 and F4 were Fickian diffusion mechanism. The stability studies of all 5% EC-coated ITP pellet formulations were conducted at room and accelerated temperature as per ICH guidelines, and results were found satisfactory. It is concluded that ethylcellulose other than Eudragit® RL/RS100 (2:1) and Kollicoat® SR 30D was found to be an excellent release controlling agent for ITP which showed good controlled-release characteristics. Note de contenu : - Materials - Methods - Physical and chemical evaluation of pellet formulations - Image analysis - In vitro drug release studies - Effect of EC coating on pellet formulations - Effect of Eudragit RL/RS 100 coating on pellet formulations - Effect of Kollicoat SR 30D coating on pellet formulations - Effect of dissolution medium on drug release - Ethylcellulose-coated pellet formulations - Eudragit RL/RS 100-coated pellet formulations - Kollicoat SR 30D-coated pellet formulations - Drug release kinetic studies - Kinetics of EC-coated pellets - Kinetics of Eudragit RL/RS100-coated pellets - Kinetics of Kollicoat SR 30D-coated pellets - Drug release mechanism - Stability studies DOI : 10.1007/s11998-019-00211-8 En ligne : https://link.springer.com/content/pdf/10.1007%2Fs11998-019-00211-8.pdf Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=33016 [article]

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