| Titre : |
Modulation of Piezo1 influences human skin architecture and oxytocin expression |
| Type de document : |
texte imprimé |
| Auteurs : |
Florian Labarrade, Auteur ; Armelle Perrin, Auteur ; Yolene Ferreira, Auteur ; Jean-Marie Botto, Auteur ; Isabelle Imbert, Auteur |
| Année de publication : |
2023 |
| Article en page(s) : |
p. 604-611 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Anticorps
Barrière cutanée
Cadhérine
Dermatologie
Mécanosensorialité
Ocytocine
Peau -- Anatomie
Peau -- Physiologie
Statistiques
Toucher
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
- Objective : Throughout our existence, the skin senses and analyses the mechanical forces imposed by the environment. In response to these environmental forces, skin can deform itself and achieve a biological response. The subsequent cutaneous plasticity emerges from mechanical properties arising from the collective action of the skin cells, particularly keratinocytes, that govern the tensile strength via cell-to-cell adhesions and via cell–matrix adhesion structures. In addition to serving as force-bearing entities, keratinocytes respond to forces by activating signalling pathways to control their own fate and function. To detect and adapt to mechanical signals, keratinocytes possess a panel of sensory receptors and junctional intercellular structures. Mechanically activated ion channel Piezo1 has been described as a force sensor and as being involved in pleasant touch perception. In this study, relationships between Piezo1 modulation and oxytocin synthesis were investigated.
- Methods : The expression of Piezo1 in the skin was studied and compared with the expression of TRPV1. Dooku1 antagonist and Jedi1 agonist were used to modulate Piezo1. The level of E-cadherin and oxytocin was monitored in ex vivo skin biopsies by immunodetection.
- Results : Taken together, our results illustrate the major role of mechanosensitive ion channel Piezo1 in skin barrier integrity, and in peripheral oxytocin synthesis in the skin.
- Conclusion : In conclusion, this study highlights the relationships between pleasant touch, soft touch and local oxytocin synthesis. |
| Note de contenu : |
- Antibodies
- Immunohistological fluorescent studies
- Haematoxylin and eosin staining
- Statistical analysis |
| DOI : |
https://doi.org/10.1111/ics.12864 |
| En ligne : |
https://drive.google.com/file/d/1Rhjjp-MCVbwC2qcra5JkPYUYHd34CP92/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=40081 |
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 45, N° 5 (10/2023) . - p. 604-611
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Modulation of Piezo1 influences human skin architecture and oxytocin expression in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 45, N° 5 (10/2023)
