Biofilm-inhibiting nanocomposite coatings on surgical sutures: durability and mechanistic insights / R. Subasri in JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH, Vol. 20, N° 1 (01/2023)  

[article]  inJOURNAL OF COATINGS TECHNOLOGY AND RESEARCH > Vol. 20, N° 1 (01/2023) . - p. 377-392 Titre : Biofilm-inhibiting nanocomposite coatings on surgical sutures: durability and mechanistic insights Type de document : texte imprimé Auteurs : R. Subasri, Auteur ; Ramay Patra, Auteur ; Manisha Yadav, Auteur ; Deepak Kumar, Auteur ; Birru Bhaskar, Auteur ; K. R. C. Soma Raju, Auteur ; Subhash Tanwar, Auteur ; Susmita Chaudhuri, Auteur ; Prashant Garg, Auteur Année de publication : 2023 Article en page(s) : p. 377-392 Note générale : Bibliogr. Langues : Américain (ame) Catégories : Antibactériens Biofilms Dispositifs médicaux Durée de vie (Ingénierie) Hydrophobie Inhibition microbienne Matériaux hybrides Matériel médical Revêtements organiques Sol-gel, Procédé Sutures (chirurgie) Index. décimale : 667.9 Revêtements et enduits Résumé : Biofilms are a critical health concern because of their ability to render tolerance and resistance against antimicrobials, which is especially challenging for surgical-site sterility and surgical wound recovery. Development of biofilm-inhibiting coatings on surgical devices could aid to limit biofilm formation at surgical site. In this context, two biofilm-inhibiting nanocomposite hydrophobic coating formulations, one with biocide and the other without biocide, were developed and deposited on various substrates such as glass, plastics, and surgical sutures, followed by biofilm inhibition evaluation. Encouraging results were obtained and reported earlier. In the present study, the biofilm-inhibiting action of coatings on surgical sutures was re-examined using a spot assay method by counting the colony-forming units. The long-term durability of the coated sutures with respect to varying temperature, humidity, inflammatory cytokines, and body fluid was studied, in order to validate their suitability for use in surgical accessories and biomedical devices. RTPCR test was carried out to look for downregulation of biofilm-forming genes. Cytotoxicity of the nanocomposite coatings was examined by carrying out an MTT assay. The downregulation of biofilm-forming genes and minimal cytotoxicity of the nanocomposite coatings further confirmed its viability for using on surgical sutures. Overall, the current study provides mechanistic insights and additional bactericidal effect of the hitherto demonstrated antibiofilm activity of the formulation. This study also establishes long-term durability of the coatings in terms of temperature, humidity, and exposure to plasma, enabling its use in surgical accessories to be commercialized in various settings. Note de contenu : - MATERIALS AND METHODS - RESULTS : Microscopic analysis of biofilm matrix - Bactericidal activity of IH and HC coatings - Durability of coatings with respect to temperature, humidity, inflammatory cytokines, and body fluids - Molecular analysis of mechanism of biofilm inhibition - Cytotoxicity analysis of IH and HC DOI : https://doi.org/10.1007/s11998-022-00678-y En ligne : https://link.springer.com/content/pdf/10.1007/s11998-022-00678-y.pdf?pdf=button Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=38849 [article]

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Experimental investigation on mechanical and thermo-mechanical properties of alumina filled polypropylene composites using injection molding process / Deepak Kumar in INTERNATIONAL POLYMER PROCESSING, Vol. XXXII, N° 3 (07/2017)  

[article]  inINTERNATIONAL POLYMER PROCESSING > Vol. XXXII, N° 3 (07/2017) . - p. 316-325 Titre : Experimental investigation on mechanical and thermo-mechanical properties of alumina filled polypropylene composites using injection molding process Type de document : texte imprimé Auteurs : Deepak Kumar, Auteur ; G. S. Dangayach, Auteur ; P. N. Rao, Auteur Année de publication : 2017 Article en page(s) : p. 316-325 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Alumine Charges (matériaux) Composites -- Moulage par injection Composites -- Propriétés mécaniques Composites -- Propriétés thermomécaniques Composites thermoplastiques Polypropylène Index. décimale : 668.4 Plastiques, vinyles Résumé : In the present study, Polypropylene composites were fabricated by varying different weight percentages (0 to 20%) of alumina powder by using Injection Molding Technique. Then the fabricated composites were characterized by physical characterization such as void content test, chemical characterization such as Fourier-transform infrared spectroscopy, mechanical characterization such as Shore hardness test, flexural test, compressive strength, Izod impact test, thermo-mechanical characterizations such as Dynamic Mechanical Analysis, Thermo-gravimetric analysis and morphological characterizations such as Scanning Electron Microscopy (SEM) and Atomic force Microscopy (AFM). The results indicate that the shore hardness values increase up to 25% with the increase in alumina filler up to 20%. The highest flexural strength and flexural modulus achieved are 59.26 MPa and 2126 MPa respectively with 20% filler loading. Further, it was also revealed that the storage modulus of the composites was found to be higher than that of the virgin PP because filler increases the stiffness of the composites. Thermo-gravimetric analysis (TGA) measurements indicate that both the initial degradation temperature and end degradation temperature increase with increasing filler content. SEM exhibits that alumina particles were uniformly and finely dispersed though some aggregates and agglomerates are identifiable. AFM results indicate that morphology of alumina in the PP matrix is characterized by a chainlike branched structure. Note de contenu : - EXPERIMENTAL : Selection of raw materials - Preparation of composite using plastics injection molding technique - Characterization of the samples - RESULTS AND DISCUSSION : FTIR spectra of alumina filled polypropylene composites - Effect of void content on alumina filled polyprpylene composites - Effect of shore hardness on alumina filled polypropylene composites - Effect of impact strength on alumina filled polypropylene composites - Effect of flexural properties on alumina filled polypropylene composites - Effect of compressive strength on alumina filled polypropylene composites - Dynamic mechanical analysis - Thermo-gravimetric analysis (TGA) - Scanning electron microscopy - Atomic force microscopy (AFM) DOI : 10.3139/217.3323 En ligne : https://drive.google.com/file/d/1Cp0fErLrNIF8T2Mh7x3QEcNsQ5bNKwmA/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=28833 [article]

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