| Titre : |
Modified smart collagen biomaterials for pharmacy and adhesive applications |
| Type de document : |
texte imprimé |
| Auteurs : |
Ján Matyasovsky, Auteur ; Ján Sedliacik, Auteur ; Igor Novák, Auteur ; Peter Simon, Auteur ; Peter Jurkovic, Auteur ; Peter Duchovic, Auteur ; Angela Kleinová, Auteur |
| Année de publication : |
2016 |
| Article en page(s) : |
p. 365-375 |
| Note générale : |
Bibliogr. |
| Langues : |
Américain (ame) |
| Catégories : |
Biomatériaux
Biopolymères
Collagène
Colles:Adhésifs
Comprimés
Préparations pharmaceutiques
Technique des plasmas
|
| Index. décimale : |
675 Technologie du cuir et de la fourrure |
| Résumé : |
Collagen has widespread use for preparation of cell cultures, dermal cosmetics, food and medicines, while achieving biocompatibility with the biological environment. Unmodified native collagen is relatively difficult to process for intended applications. This work presents potential application possibilities of modified collagen biopolymer for pharmacy and adhesive applications.
Firstly, the application possibilities of collagen in the system of controlled drug release were verified. Dissolution profile of the matrix Ambroxol hydrochloride and Venlafaxine confirmed potential of crosslinked and plasticized collagen as a pharmaceutical agent for the solid medicinal product. This product was prepared by direct compression with controlled drug release within the 8-11 hours with almost zero-order kinetics.
Secondly, low temperature plasma was applied to achieve the biocompatibility and to modify the film surface of the collagen type I. Collagen film was treated in two plasma environments ; low temperature plasma N2/H2 was used for grafting the amino groups and CO2 plasma ensured grafting the carboxyl groups. The surface functional groups of collagen were applied in further reactions (e.g., antimicrobial pretreatment with strong biocide properties). Functionalized collagen film provided stronger adhesion and compatibility. Prepared non-formaldehyde collagen thermoplastic adhesive was tested for the technical applications. The results have shown that the collagen adhesive bond gained high strength, flexibility and required strong gluing, e.g. books or wood veneered materials. |
| Note de contenu : |
- EXPERIMENTAL : Materials and methods - Used drug and excipient : Ambroxol hydrochloride - Venlafaxine hydrochloride - Collagen BS - Collagen HS - Collagen K 12 - Ethylene vinyl acetate - Methocel - Measurement methods : Tablet pressing - Mechanical testing of tablets - Disintegration of tablets - Dissolution of tablets - Surface and adhesion properties of EVAc films with collagen - Plasma modification - ATR-FTIR spectroscopy measurements - Plywood preparation
- RESULTS AND DISCUSSION : Application of modified collagen in pharmacy - Non-crosslinked collagen hydrolysate as the tablet binder - Tests of controlled release of ambroxol from the tablet matrix - Surface and adhesion properties of the film sample with collagen - Surface and adhesion properties of collagen based thermoplastic hot-melt films - Determination of the bond quality of plywood boards with collagen films |
| En ligne : |
https://drive.google.com/file/d/1rpwqGlXtr2bK6lN5uetRB1sMM9yjke9u/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=27022 |
in JOURNAL OF THE AMERICAN LEATHER CHEMISTS ASSOCIATION (JALCA) > Vol. CXI, N° 10 (10/2016) . - p. 365-375
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