| Titre : |
Bacterial skin microbiota/microbiome investigation |
| Type de document : |
texte imprimé |
| Auteurs : |
Fabrice Perin, Auteur ; Kunyanatt Chalothorn, Auteur ; Preeyanuch Tachalerdmanee, Auteur |
| Année de publication : |
2018 |
| Article en page(s) : |
p. 65-68 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Dermatologie
Flore cutanée
Microbiologie
Microbiome cutané
Microbiote
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
We have almost reached the point where we can characterise nearly exhaustively the bacteria inhabiting the skin and microbiome research has already improved our understanding the pathogenesis of some disease. However many questions still remain. Firstly, we are not assured to really understand of what defines a healthy microbiota. Scientists have started to find associations of some skin diseases or particular skin conditions with particular microbial species but the causality relationship is often not demonstrated yet. Secondly, little is known about the persistance of bacterial populations, the causes and consequences of their time fluctuations. We know virtually nothing about most metabolites that are produced by skin bacteria in vivo, even though these are the key molecules responsible for the cross-talks between microbes and their human host. This point is of utmost importance since we have to decipher the mechanistic bases (particulary the chemical signals) for interactions between members of microbial communities and their hosts or the mechanisms that underlie associations between specific skin area and their respective microbiota. Next generation high-throughput sequencing and development of novel bioinformatics approaches will certainly help to fill these gaps in our knowledge of microbiome physiological effects. Then, we will have a chance to be able to modulate particular bacteria within the skin microbiota community, to use probiotics to modify the gut microbiome to achieve 'beauty from within' objectives, to manipulate host-microbial homeostasis without risking to create unforessen adverse outcome. Rational microbiome-based interventions using local application of selected bacteria or topical treatments modulating bacterial activity could thus become an essential tool in the field of personalised cosmetic and medical treatments. For instance, the feasibility of microbiome-based skin diagnosis has already been proven for psoriasis patients. |
| Note de contenu : |
- Microbiota of healthy and diseased skin
- Designing skin microbiome studies
- Fig. 1 : Relative proportions of the bacteria versus human cells and the microbiome versus genes. Bacteria hosted by the body outnumber human cells by a factor of 10 and that the microbiome has 150 times more genes than the human body does
- Fig. 2 : Conducting a microbiome study step by step : 1) samping of skin microbial community ; 2) extraction of DNA ; 3) amplification and sequencing using the 16S-based approach or whole genome shotgun (WGS) metagenomic sequencing ; 4) taxonomic classification, community composition and functions |
| En ligne : |
https://drive.google.com/file/d/1lpFxiBUxw39cQAb5eKy2lyiH9XWjSWMH/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=31144 |
in PERSONAL CARE EUROPE > Vol. 12, N° 4 (09/2018) . - p. 65-68
Aller sur edunet
Accueil
Bacterial skin microbiota/microbiome investigation in PERSONAL CARE EUROPE, Vol. 12, N° 4 (09/2018)
