[article]
| Titre : |
Study examines epigenetic regulation of melanogenesis |
| Type de document : |
texte imprimé |
| Auteurs : |
Neil Astles, Auteur ; Ludivine Mur, Auteur ; Florian Labarrade, Auteur ; Catherine Gondran, Auteur ; Nouha Domloge, Auteur ; Sophia Antipolis, Auteur |
| Année de publication : |
2015 |
| Article en page(s) : |
p. 73-76 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Agents de blanchiment
Cosmétiques
EpigénétiqueL'épigénétique (mot-valise de "épigenèse" et "génétique") est la discipline de la biologie qui étudie la nature des mécanismes modifiant de manière réversible, transmissible (lors des divisions cellulaires) et adaptative l'expression des gènes sans en changer la séquence nucléotidique (ADN)
"Alors que la génétique correspond à l'étude des gènes, l'épigénétique s’intéresse à une "couche" d’informations complémentaires qui définit comment ces gènes vont être utilisés par une cellule ou… ne pas l'être".
"C'est un concept qui dément en partie la "fatalité" des gènes".
Formulation (Génie chimique)
Mélanogénèse
Peau -- Soins et hygiène
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Over the past several years, a number of scientific papers have been published that suggest the skin pigmentation process can be fully mapped by following the cellular pathways and the molecules involved in melanogenesis. Indeed, it has been know for years that epidermal units within the skin generally serve to produce and distribute melanin; however,the regulatory process that controls pigmentation is now only coming into view; Understanding the regulatory pathways to melanogenesis will help the cosmetics industry in their effort to develop safe and effective strategies to temporarily brighten skin tone for cosmetic effects.
Epigenetics is a process that leads to stable and heritable changes in gene expression without changes in the underlying DNA sequences. A new area of study, epigenetics science opens the door to discovery of melanin regulation. The research effort finds its roots in the medical community, where it is postulated that new approaches to treating cancer other than fixing or replacing damaged genes may also help to improve patient outcomes.
The opening for epigenetic science began about 25 years ago after scientists discovered a distinct class of biologic regulators called miRNA. These small non-coding ribonucleic acids serve to fine tune the expresson of approximately 30% of all protein-encoding genes. The miRNA usually induces gene silencing by binding to messager RNA (mRNA). The interaction of a miRNA and its mRNA targets tends to prevent protein production by suppressing mRNA translation and/or by prompting mRNA degradation.
The following research describes pathways to modulate miRNA epigeetic regullators in skin cells for cosmetic effects. Research outlining the down-regulation of miRNA-29a and the resulting effects in collagen synthesis and in prolidase activity is introduced as an example of the potential to utilise miRNA pathways to improve the appearance of skin. Moreover, miRNA-218 is considered for its role in regulating melanogenesis. A clinical study with 35 volunteers is also described, wherein hexapeptide-2(Trade Name : Dermostatyl IS biofunctional) is examined for its ability to brighten skin tone. |
| En ligne : |
https://drive.google.com/file/d/18Q4_iCLlQpR2htJRg1sqJqMjs1ykvGQy/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=24964 |
in PERSONAL CARE EUROPE > Vol. 8, N° 6 (11/2015) . - p. 73-76
[article]
|
Aller sur edunet
Accueil
Ajouter le résultat dans votre panier Affiner la rechercheBiofunctional offers telomere approach to anti-ageing / Neil Astles in PERSONAL CARE EUROPE, Vol. 5, N° 5 (11/2012)
