Niacinamide mitigates SASP-related inflammation induced by environmental stressors in human epidermal keratinocytes and skin / John C. Bierman in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 42, N° 5 (10/2021)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 42, N° 5 (10/2021) . - p. 501-511 Titre : Niacinamide mitigates SASP-related inflammation induced by environmental stressors in human epidermal keratinocytes and skin Type de document : document électronique Auteurs : John C. Bierman, Auteur ; Timothy Laughlin, Auteur ; Makio Tamura, Auteur ; Ben C. Hulette, Auteur ; Catherine E. Mack, Auteur ; Joseph D. Sherrill, Auteur ; Christina Y. R. Tan, Auteur ; Malgorzata Morenc, Auteur ; Sophie Bellanger, Auteur ; John. E Oblong, Auteur Année de publication : 2020 Article en page(s) : p. 501-511 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Anti-inflammatoires Cellules -- Cultures et milieux de culture Justification de l'allégation Nicotinamide Peau -- Inflammation Peau -- Physiologie Stress -- Effets physiologiques Stress environnemental Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : To evaluate whether niacinamide (Nam) can mitigate production of inflammatory and senescence-related biomarkers induced by environmental stressors. - Methods : Human epidermal keratinocytes were exposed to UVB, urban dust, diesel exhaust and cigarette smoke extract and treated with Nam or vehicle control. Full thickness 3-D skin organotypic models were exposed to a combination of UVB and PM2.5 and treated with Nam or vehicle control. Quantitation of the SASP-related inflammatory mediators PGE2, IL-6 and IL-8 was performed on cultured media. UVB-exposed keratinocytes treated with and without Nam were immunostained for the senescence biomarker Lamin B1 (LmnB1). Transcriptomics profiling of cigarette smoke extract effects on keratinocytes was performed. A double-blind, placebo-controlled clinical was conducted on 40 female panellists that were pretreated on back sites for two weeks with 5% Nam or vehicle and then exposed to 1.5 minimal erythemal dose (MED) solar-simulated radiation (SSR). Treated sites were compared with non-treated exposed sites for erythema and the skin surface IL-1αRA/IL-1α inflammatory biomarkers. - Results : Ultraviolet B induced synthesis of PGE2, IL-8 and IL-6 and reduced LmnB1 levels in keratinocytes. Urban dust and diesel exhaust only stimulated synthesis of IL-8 whereas cigarette smoke extract only stimulated levels of PGE2. In all exposures, treatment with Nam significantly mitigated synthesis of the inflammatory mediators and restored levels of UVB-reduced LmnB1. In the 3D skin equivalent model, Nam reduced IL-8 levels stimulated by a combination of topical PM2.5 and UV exposure. In a UV challenge clinical, pretreatment with 5% Nam reduced erythema and skin surface IL-1αRA/IL-1α inflammatory biomarkers that were induced by SSR. - Conclusion : Since it is known that Nam has anti-inflammatory properties, we tested whether Nam can inhibit environmental stress-induced inflammation and senescence-associated secretory phenotype (SASP) biomarkers. We show Nam can reduce PGE2, IL-6 and IL-8 levels induced by environmental stressors. Additionally, in vivo pretreatment with Nam can reduce UV-induced erythema and skin surface inflammatory biomarkers. These findings add to the body of evidence that Nam can mitigate the skin’s inflammatory response elicited by environmental stressors. This supports Nam can potentially inhibit senescence and premature ageing and thereby maintain skin’s functionality and appearance. Note de contenu : - MATERIALS AND METHODS : Cells and reagents - ATP measurement - PGE2, IL-6 and IL-8 measurements - Lamin B1 and Ki-67 immunofluorescence staining - Eigene gene analysis - UV challenge study - RESULTS : Nam mitigates UV-induced inflammatory response - Secretion of inflammatory signals and gene expression patterns induced by environmental stressors in keratinocytes is mitigated by Nam - Treatment with topical 5% Nam can reduce UV-induced erythema and the ratio of the skin surface inflammatory biomarkers IL-1 aRA/IL-1 a DOI : https://doi.org/10.1111/ics.12651 En ligne : https://drive.google.com/file/d/1JMyefjRlUnyZowe-9UsgBOlh5jEiZyVL/view?usp=shari [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=35415 [article]

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A review of the range of effects of niacinamide in human skin / Paul J. Matts in IFSCC MAGAZINE, Vol. 5, N° 4 (10-11-12/2002)

[article]  inIFSCC MAGAZINE > Vol. 5, N° 4 (10-11-12/2002) . - p. 285-289 Titre : A review of the range of effects of niacinamide in human skin Type de document : texte imprimé Auteurs : Paul J. Matts, Auteur ; John. E Oblong, Auteur ; D. L. Bissett, Auteur Année de publication : 2002 Article en page(s) : p. 285-289 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Céramides Un céramide est un sphingolipide résultant de la combinaison d'un acide gras avec la sphingosine via une liaison amide. On trouve de telles molécules en abondance dans les membranes cellulaires, où elles entrent notamment dans la constitution des sphingomyélines. Les céramides ne jouent pas qu'un rôle structurel dans les membranes biologiques, et peuvent également revêtir des fonctions de signalisation lipidique. Leurs actions les mieux comprises vont de la différenciation cellulaire à la mort cellulaire programmée (apoptose) en passant par la prolifération cellulaire. Les acides gras qui les constituent ont généralement un nombre pair (de 16 à 24) d'atomes de carbone, sont saturés ou monoinsaturés, et sont souvent α-hydroxylés. La plupart des céramides n'existent pas à l'état naturel si ce n'est comme précurseurs de la biosynthèse des sphingolipides par une réaction d'addition sur la fonction alcool primaire de la sphingosine. (Wikipedia) Nicotinamide Peau Peau -- Soins et hygiène Index. décimale : 668.5 Parfums et cosmétiques Résumé : Niacinamide (also known as nicotinamide, 3-pyridinecarboxamide) is the physiologically active form of niacin or vitamin B3, the deficiency of which results in the nutritional disease pellagra with distinct cutaneous manifestations. Since its discovery and isolation, a host of dermatological therapeutic benefits and mechanisms have also been ascribed to this essential water-soluble vitamin when used as a topical agent. These include its apparent role as an anti-acne active, an up-regulator of epidermal sphingo-lipid synthesis, an up-regulator of markers of epidermal differentiation and dermal proliferation (with concurrent stratum corneum barrrier benefits), and as a moderator of photoimmune suppression and accompanying tumor genesis. More recently, fresh evidence points to a role in modifying the cosmetic appearance of skin through suppression of epidermal melanosome transfer with subsequent effect on skin pigmentation and a role in modifying epidermal surface topography. The mechanisms for these cutaneous effects are still unclear. However, since niacinamide is an important precursor of NADH and NADPH, it has been postulated that topical application of niacinamide can promote this reported broad spectrum of activity through local correction of homeostatic balance of these two nucleotide coenzymes. As there has been a dramatic increase in research into and use of niacinamide in recent years, this review will cover the current scope of knowledge of this important vitamin, including mechanistic understanding and cutaneous physiological activity. Note de contenu : - History of niacinamide - Physiological role of niacinamide - Nicotinamide coenzymes in skin are depleted with age ; niacinamide can help normalize this imbalance - Age fibroblasts secrete less collagen than young cells ; nicaninamide can stimulate new synthese - Niacinamide up-regulates epidermal ceramide synthesis with concurrent epidermal barrier benefits - Niacinamide up-regulates biosynthesis of markers of keratinocyte differentiation - Niacinamide helps prevent UV-induced deleterious molecular and immunological events - Niacinamide inhibits transfer of melanosomes from melanocytes to keratinocytes - Regulation of sebaceous lipid and acne by niacinamide - Niacinamide exerts multipl benefits on the appearance of ageing/photodamaged skin in-vivo - Niacinamide is delivered effectively from a range of vehicles and demonstrates excellent skin compatibility Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10629 [article]

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Topical niacinamide does not stimulate hair growth based on the existing body of evidence / John. E Oblong in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 42, N° 2 (04/2020)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 42, N° 2 (04/2020) . - p. 217-219 Titre : Topical niacinamide does not stimulate hair growth based on the existing body of evidence Type de document : texte imprimé Auteurs : John. E Oblong, Auteur ; A. W. Peplow, Auteur ; S. M. Hartmann, Auteur ; M. G. Davis, Auteur Année de publication : 2020 Article en page(s) : p. 217-219 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Cheveux -- Croissance Nicotinamide Index. décimale : 668.5 Parfums et cosmétiques Résumé : Niacinamide has been suggested to impact hair biology via stimulation of VEGF synthesis. Testing in an in vitro VEGF synthesis assay, it was found that niacinamide cannot stimulate VEGF synthesis across a broad dose–response range. DOI : https://doi.org/10.1111/ics.12599 En ligne : https://drive.google.com/file/d/17rmcMv2WoBKhEeDWFwOaFiQzRiQyCiZO/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=34512 [article]

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