| Titre : |
The application of mixed micelle theory to personal care ingredients |
| Type de document : |
texte imprimé |
| Auteurs : |
John Gormley, Auteur ; Chris Cook, Auteur |
| Année de publication : |
2003 |
| Article en page(s) : |
p. 133-138 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Concentration micellaire critique
Micelles
Parabènes
Produits de toilette
Surfactants
|
| Tags : |
'Synergie d'agent tensio-actif' 'Théorie régulière de solution' 'Compteur-irritation' 'Nettoyage doux' 'Efficacité des parabens' |
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Specific surfactant blends may contribute to reduce irritation by synergistically lowering the critical micelle concentration (CMC)and the monomer level of the more irritating surfactant in bulk solution. A computer program was made and used to calculate molecular interaction parameters (beta) using the widely accepted regular solution theory. This information allowed for the prediction of monomer levels at and above the CMC in mixed surfactant solutions having known CMC values. Such information is included for a series of amphoteric surfactants interacting with SLES-2 at pH 7 and ranked according to their efficiency in lowering the free anionic monomer content in the bulk phase. There is strong debate over whether a correlation truly exists between skin irritancy and CMC techniques. This technique and software provide part of the data set that can help support of refuse such a correlation.
This technique was also used to prescreen a developmental non-ionic surfactant for counter-irritancy with C14-16 alpha olefin sulfonates. The test surfactant was found to lack synergy with the anionic mixture, thus predicting that it would not be a milder system. This prescreening prevented testing this system on humans or animals.
The model was extended to calculate the interaction of Polysorbate-20 with propylparaben. The free active level(ex-micelle) of preservative was calculated as a function of total amount of preservative added. A strong interaction reduced the unbound propylparaben concentration such that anti-microbial activity was lost. |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10604 |
in IFSCC MAGAZINE > Vol. 6, N° 2 (04-05-06/2003) . - p. 133-138
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