[article]
| Titre : |
PCA, A key NMF component, enhances micro blood circulation by modulating constitutive NO production |
| Type de document : |
texte imprimé |
| Auteurs : |
Kazuko Ogasahara, Auteur ; Manabu Kitazawa, Auteur ; Hiroshi Hayashi, Auteur |
| Année de publication : |
2003 |
| Article en page(s) : |
p. 229-232 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Tags : |
'Amino acid transport' 'L-arginine (L-Arg)' 'Human aortic endothelial cells' 'Micro blood circulation' 'Nitric oxide (NO)' 'L-2-pyrrolidone-5-carboxylic (L-PCA)' |
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
This study revealed an intrinsic biological function of 2-pyrrolidone-5-carboxylic acid (L-PCA) to enhance micro blood circulation by modulating constitutive nitric oxide (NO) production. It is well known that NO, generated from L-arginine (L-Arg) by the action of NO synthase (NOS), plays a key role in the control of vascular tone and peripheral blood flow. In these studies we found a dose-dependent enhancement of constitutive NO production by L-PCA in human aortic endothelial cells. In contrast, D-PCA had no influence on NO production. Furthermore, L-PCA stimulated L-Arg uptake into human aortic endothelial cells in a dose-dependent manner while D-PCA had no effect, similar to its effect on NO production. L-Arg uptake and its stimulation by L-PCA to human aortic endothelial cells were suppressed with the cationic amino acid transporter. This result suggests that the enhancement of the NO production by L-PCA is due to the increase of L-Arg uptake via cationic amino acid transporter pathway. In conclusion, we found that L-PCA enhances micro blood circulation via a modulation of constitutive NO production. This intrinsic biological effect of L-PCA could lead to the development of innovative cosmetic products to care for problematic skin, such as dark circles under the eyes where a reduced micro blood circulation is one of the underlying causes. |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10585 |
in IFSCC MAGAZINE > Vol. 6, N° 3 (07-08-09/2003) . - p. 229-232
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