Small proteoglycans in the skin : new targets in the fight against skin aging / Gilles Pauly in IFSCC MAGAZINE, Vol. 11, N° 1 (01-02-03/2008)

[article]  inIFSCC MAGAZINE > Vol. 11, N° 1 (01-02-03/2008) . - p. 21-29 Titre : Small proteoglycans in the skin : new targets in the fight against skin aging Type de document : texte imprimé Auteurs : Gilles Pauly, Auteur ; Jean-Luc Contet-Audonneau, Auteur ; Philippe Moussou, Auteur ; Louis Danoux, Auteur ; Vincent Bardey, Auteur ; Olga Freis, Auteur ; Mélanie Sabadotto, Auteur ; Yanusz Wegrowski, Auteur ; François-Xavier Maquart, Auteur ; Andreas Rathjens, Auteur Année de publication : 2008 Article en page(s) : p. 21-29 Note générale : Bibliogr. Langues : Anglais (eng) Tags : Glycosaminoglycanes  Protéoglycanes  Syndécane  Lumicane  Vieillissement Index. décimale : 668.5 Parfums et cosmétiques Résumé : Proteoglycans take an important part in tissue homeostasis. In the skin, Proteoglycans are present in the extracellular matrix of dermis, particularly with lumican which plays an important role in dermal homeostasis. In the epidermis, several small proteoglycans such as the syndecans are synthesized and play an important role in keratinocyte activation. There is much data on the alteration during skin aging of the synthesis and structure of glycosaminoglycans and some proteoglycans but little information on small proteoglycans, in particular lumican and syndecan-1. We recently observed a decrease in the synthesis of these two small proteoglycans with aging. We confirm in this work the decrease in lumican in dermis and syndecan-1 in epidermis with aging. These proteoglycans represent original important targets for cosmetology in the fight against skin aging. In different in vitro models, two synthetic acetyl tetrapeptides, AcTP1 and AcTP2, stimulate the synthesis of lumican and syndecan-1, respectively. The beneficial action of AcTP1 on skin thickness and firmness and of AcTP2 on epidermal cohesion has been confirmed in vivo. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10385 [article]

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What is the most suitable strategy for stress proteins in cosmetics? / Christine Jeanmaire in IFSCC MAGAZINE, Vol. 6, N° 3 (07-08-09/2003)

[article]  inIFSCC MAGAZINE > Vol. 6, N° 3 (07-08-09/2003) . - p. 221-226 Titre : What is the most suitable strategy for stress proteins in cosmetics? Type de document : texte imprimé Auteurs : Christine Jeanmaire, Auteur ; Vincent Bardey, Auteur ; Louis Danoux, Auteur ; Philippe Moser, Auteur ; Philippe Moussou, Auteur ; Gilles Pauly, Auteur Année de publication : 2003 Article en page(s) : p. 221-226 Note générale : Bibliogr. Langues : Anglais (eng) Tags : Cytoprotection  'Heat  shock  proteins'  Pollution  Skin  'Skin  defense'  Stress  UV Index. décimale : 668.5 Parfums et cosmétiques Résumé : Under various stress conditions, heat shock protein expression is enhanced in cells. Working on skin pieces, two of the major skin-expressed heat shock proteins, HSP72 and HSP27, were visualized by immunohistochemistry after several stress conditions (UV, pollutants, thermal shocks) and the heat shock protein expression quantified in the epidermis. A strong increase of the epidermal heat shock protein expression, due to these different stresses, was observed. The most suitable cosmetic strategy is discussed: does one need to prevent or to favor heat shock protein induction in cutaneous cells? A prevention strategy is suitable in the case of acute stress, such as severe UV exposure that provokes cell damage and a strong induction of heat shock proteins. It is demonstrated that, using a photoprotective active ingredient Sunactyl®, suppression of the heat shock protein expression of cells is linked to a protection of the cells against UV induced damages. An induction strategy is appropriate for chronic daily stress from various sources. Seeing that a small and controlled induction of heat shock proteins in the skin speeds up the response and enhances the cellular resistance to further stress, HSP-Balance® was developed, which boosts the heat shock protein induction in the skin under stress conditions. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10584 [article]

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