Free radicals induce Acne aestivalis in sensitive subjects / Katinka Jung in PERSONAL CARE EUROPE, Vol. 12, N° 5 (11/2018)  

[article]  inPERSONAL CARE EUROPE > Vol. 12, N° 5 (11/2018) . - P. 66-69 Titre : Free radicals induce Acne aestivalis in sensitive subjects Type de document : texte imprimé Auteurs : Katinka Jung, Auteur ; Thomas Herrling, Auteur ; Ulrike Heinrich, Auteur ; Hagen Tronnier, Auteur ; Marcel Schnyder, Auteur ; Bernd Herzog, Auteur Année de publication : 2018 Article en page(s) : P. 66-69 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Acné L'acné (nom féminin) est une dermatose (maladie de la peau) inflammatoire des follicules pilosébacés (glandes sécrétant le sébum, à la racine des poils) avec formation de comédons. Cette maladie de la peau est représentée dans sa forme la plus fréquente par l'acné polymorphe juvénile qui touche les adolescents, mais qui ne résume pas toutes les acnés. Il existe aussi des acnés exogènes d'origine professionnelle, médicamenteuse, cosmétique... Etudes cliniques Formulation (Génie chimique) Peau -- Physiopathologie Peau -- Soins et hygiène Produits antisolaires Radicaux libres (chimie) Index. décimale : 668.5 Parfums et cosmétiques Résumé : The market segment of sun care products to protect sensitive skin is growing. There is evidence that peroxide free radicals derived from certain formulation components are involved in inducing allergic skin reactions. These UV-induced free radicals can be assessed by an ESR-based method called Radical Potential (RP), by exposing formulations to UV radiation. BASF experts found a correlation between the amount of UV-inducible peroxides in sunscreen products and the clinical symptoms of Acne aestivalis and, potentially, other types of skin reactions. Their findings offer a rationale for developing low-risk sunscreen formulations by selecting suitable filter systems combined with in-situ ESR analysis. Note de contenu : - Assessing the radical potential - Radical Potential method - Clinical study - Fig. 1 : Free radical generation in a cosmetic formulation (placebo) spiked with natural oil or perfume oils (PO) - Fig. 2 : Score evaluation of the clinical study - Table 1 : INCI of the SPF 30 sunscreen formulas 12-1 and 12-2 - Table 2 : Relative amount of free radicals, N=2 - Table 3 : Part 1 : Score value - Table 4 : Evaluation of the adverse skin reaction of treated subjects where 24 is the sum of the highest possible skin reaction (score value 4 x 6 subjects) En ligne : https://drive.google.com/file/d/178PeTFtn_HAAy0Wm8IK12VbwvVj8V1qs/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=31287 [article]

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High levels of free radicals in suncare products induce acne aestivalis in sensitive subjects / Katinka Jung in SOFW JOURNAL, Vol. 142, N° 3 (03/2016)  

[article]  inSOFW JOURNAL > Vol. 142, N° 3 (03/2016) . - p. 2-8 Titre : High levels of free radicals in suncare products induce acne aestivalis in sensitive subjects Type de document : texte imprimé Auteurs : Katinka Jung, Auteur ; Thomas Herrling, Auteur ; Ulrike Heinrich, Auteur ; Hagen Tronnier, Auteur ; Marcel Schnyder, Auteur ; Bernd Herzog, Auteur Année de publication : 2016 Article en page(s) : p. 2-8 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Acné L'acné (nom féminin) est une dermatose (maladie de la peau) inflammatoire des follicules pilosébacés (glandes sécrétant le sébum, à la racine des poils) avec formation de comédons. Cette maladie de la peau est représentée dans sa forme la plus fréquente par l'acné polymorphe juvénile qui touche les adolescents, mais qui ne résume pas toutes les acnés. Il existe aussi des acnés exogènes d'origine professionnelle, médicamenteuse, cosmétique... Cosmétiques -- Toxicologie Peau -- Inflammation Produits antisolaires Radicaux libres (chimie) Index. décimale : 668.5 Parfums et cosmétiques Résumé : The market segment of suncare products for protection of sensitive skin against photodermatosis is growing. Speciflcally, proection against Acne aestivalis ("Mallorca-Acne") is perceived as a strong claim for this product category. There is evidence that peroxide free radicals, deriving from certain formulation components, are involved in the induction of photo-toxic skin reactions. These UV-incluced free radicals can be assessed by an ESR-based method called Radical Potential (RP), by exposing formulations to UV radiation. The aim of this study was to find a correlation between the amount of UV inducible peroxides of sunscreen products and the clinical symptoms of Acne aestivalis. Two sunscreen formulas (SPF 30) containing organic UV-filters only, with an identical protection in the UV B region and a comparable protection in the UV A spectral range, have been produced. For both formulations the amount of UV-inducible free radicals was assessed by the RP (Radical Potential). In addition, bath formulas were tested in a clinical study with subjects with a history of Acne aestivalis. Very different RP values (levels of UV-induced free radicals) and completely different skin reactivity have been obtained, where an excellent correlation between the in vitro-parameter (RP) and the clinical symptoms could be shown. To our knowledge these results for the first time provide direct evidence for a strong correlation between UV inducible free radicals of formulations and the potential to induce A. aestivalis in sensitive subjects. Furthermore it offers a nationale for the development of law risk sunscreen formulations by selection of suitable filter systems combined with in situ ESR analysis. En ligne : https://drive.google.com/file/d/1xcreNyUK6raAM1sApbAVUsl5N9UabkIH/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=26668 [article]

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In vivo anti-aging efficacy of a cyclic peptide composition / Ruediger Graf in IFSCC MAGAZINE, Vol. 15, N° 1 (01-02/2012)

[article]  inIFSCC MAGAZINE > Vol. 15, N° 1 (01-02/2012) . - p. 23-27 Titre : In vivo anti-aging efficacy of a cyclic peptide composition Type de document : document électronique Auteurs : Ruediger Graf, Auteur ; Karl-August Reiffen, Auteur ; Soheila Anzali, Auteur ; Ulrike Heinrich, Auteur ; Hagen Tronnier, Auteur ; Hansjürgen Driller, Auteur ; Frank Pfluecker, Auteur Année de publication : 2012 Article en page(s) : p. 23-27 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge:Antirides Intégrine Matrice extracellulaire Peptides cycliques Index. décimale : 668.5 Parfums et cosmétiques Résumé : Aging affects the composition and morphological structure of the different compartments of the skin. Integrins, as an important family of transmembrane receptors, play a key role in cell-matrix interactions and are involved in cell signaling. Binding of specific ligands within the extracellular matrix to these receptors is a crucial step to maintain a vital tissue structure. For this reason a selective cyclic peptide containing an arginine-glycine-aspartic acid (RGD) sequence was designed for cosmetic applications. The objective of the present work was to evaluate the binding efficiency of different RGD peptides to specific integrins. The cyclic RGD peptide was tested in a placebo-controlled study with human volunteers with respect to its anti-aging efficacy in vivo. The results of the ligand inhibition assay with immobilized integrins clearly demonstrated that only the cyclic conformation of the RGD motif motively binds to the integrin receptors In terms of anti-aging properties, this in vivo trial confirmed the results of previous in vitro investigations where a positive effect on wrinkle reduction was observed. Our present work again supports the hypothesis that this specific RGD peptide composition successfully mimics the biological function of extracellular matrix proteins by activating signaling pathways and targets involved in the prevention of aging. Note de contenu : - EXPERIMENTAL : Ligand inhibition assay with immobilized integrins - Statistical evaluation of the in vivo data - RESULTS AND DISCUSSION : Ligand inhibition assay - In vivo volunteer study : impact on wrinkle volume and anti-aging efficacy Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=13671 [article]

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Optoacoustics – its application in photodermatology / Merve Meinhardt-Wollweber in IFSCC MAGAZINE, Vol. 12, N° 4 (10-11-12/2009)

[article]  inIFSCC MAGAZINE > Vol. 12, N° 4 (10-11-12/2009) . - p. 365-370 Titre : Optoacoustics – its application in photodermatology Type de document : texte imprimé Auteurs : Merve Meinhardt-Wollweber, Auteur ; Ronald Krebs, Auteur ; Ulrike Heinrich, Auteur ; Hagen Tronnier, Auteur ; Angelika Anders-von Ahlften, Auteur Année de publication : 2010 Article en page(s) : p. 365-370 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Peau -- Effet du rayonnement ultraviolet Spectres d'absorption Tags : Peau  'Radiation  ultraviolette'  Optoacoustique  'Propriétés  optiques'  'Effets  des  UV' Index. décimale : 668.5 Parfums et cosmétiques Résumé : Optoacoustics is a new method to study the optical properties of human skin in vivo. We measured the absorption spectra of human skin in a study in twenty subjects belonging to skin phototypes I-IV. Absorption coefficients were determined in the range from 290 nm to 341 nm (3 nm steps) on the inner and outer side of the forearm and the ball of the thumb. Comparison of these new data with known action spectra of photobiologic effects and natural solar irradiation spectra indicates that the small wavelength range from ca. 300 nm to 320 nm may be responsible for significant detrimental and beneficial effects. Consequently, the skin is very sensitive to changes in irradiation in this spectral region. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10140 [article]

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Supplementation with nutritional cartilage extract positively influences skin hydratation, skin barrier and skin structure : a double-blind, randomized, placebo-controlled study / Ulrike Heinrich in IFSCC MAGAZINE, Vol. 9, N° 4 (10-11-12/2006)

[article]  inIFSCC MAGAZINE > Vol. 9, N° 4 (10-11-12/2006) . - p. 319-323 Titre : Supplementation with nutritional cartilage extract positively influences skin hydratation, skin barrier and skin structure : a double-blind, randomized, placebo-controlled study Type de document : texte imprimé Auteurs : Ulrike Heinrich, Auteur ; Birgit Garbe, Auteur ; Hagen Tronnier, Auteur ; Marie Béjot, Auteur ; Jean Marc Maurette, Auteur Année de publication : 2007 Article en page(s) : p. 319-323 Note générale : Bibliogr. Langues : Anglais (eng) Tags : Nutrition  Suppléments  'Extrait  de  cartilage'  'Hydratation  la  peau'  'Barrière  'Structure Index. décimale : 668.5 Parfums et cosmétiques Résumé : The aim of the study was to evaluate the efficacy of polysaccharides from fish cartilage with regard to their skin aging properties. An application test was carried out during the intake of cartilage tablets as a nutritional supplement. The study was designed as a monocentric, double-blind, randomized, placebo-controlled-application test. 28 healthy female volunteers (35-60 years) with dry skin were included in the study. They were divided into two groups. Group 1 received tablets containing placebo and group 2 the verum treatment (cartilage hydrolytase combined with vitamin C). The duration of the study was 12 weeks. The focus of interest was to find out about the hydration properties, and to see whether the skin barrier and structure were influenced by the test formulation compared with placebo. Hydration measurements were made before and during the study, and the transepidermal water loss (barrierer function of the skin) was measured. The thickness and density of the skin of all volunteers were determined by means of ultrasound measurements during of the study. Statistical analysis was based on the Wilcoxon signed rank test. The following results were obtained in this study : there was a significant improvement in the hydration properties, a significant decrease in transepidermal water loss and a significant increase in the skin density in the verum group (cartilage extract). Nor or minor improvements could be detected in the placebo group. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10437 [article]

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