Titre : |
Crocus bulb extract prompts epidermis/dermis crosstalk |
Type de document : |
texte imprimé |
Auteurs : |
Jasmin Lozza, Auteur ; Daniel Schmid, Auteur ; Esther Belser, Auteur ; Fred Zülli, Auteur |
Année de publication : |
2012 |
Article en page(s) : |
p. 51-54 |
Note générale : |
Bibliogr. |
Langues : |
Anglais (eng) |
Catégories : |
Collagène -- Synthèse Cosmétiques Elastine -- Synthèse Etudes cliniques Extraits de plantes:Extraits (pharmacie) Peau -- Soins et hygiène
|
Index. décimale : |
668.5 Parfums et cosmétiques |
Résumé : |
The epidermis communicates with the subjacent dermis via signalling molecules. This crosstalk is particularly important for the regulation of complex events such as wound healing, but also for continuous tissue repair and regeneration. The messenger molecules involved are mainly cytokines and growth factors. An imbalance in the synthesis and release of these signals as it is observed in elderly skin may lead to a reduced biosynthesis of important extracellular-matrix (ECM) proteins such as collagen and elastin. Here we present a strategy to activate matrix protein production by stimulating growth factor synthesis and release by keratinocytes, which can easily be reached by superficially applied cosmetic compounds. In vitro assays demonstrate that a crocus bulb extract can activate expression of elastin, lysyl oxidase-like 2 enzyme (LOXL2) and the connective tissue growth factor (CTGF). Non-invasive skin structure analysis by two-photon microscopy performed after a two-week treatment with a cream containing the crocus bulb extract demonstrates a clear augmentation of collagen and elastine. |
Note de contenu : |
- MATERIALS AND METHODS : Preparation of extracts from plant bulbs - Screening assay
- CLINICAL STUDY USING TWO-PHOTON MICROSCOPY
- CLINICAL ANTI-AGEING STUDY |
Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=15787 |
in PERSONAL CARE EUROPE > Vol. 5, N° 4 (09/2012) . - p. 51-54