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Development of effects of plant extracts on the activity and expression of UVA-induced MMPs (matrix metalloproteases) / Dong-hwan Lee in IFSCC MAGAZINE, Vol. 7, N° 3 (07-08-09/2004)
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Titre : Development of effects of plant extracts on the activity and expression of UVA-induced MMPs (matrix metalloproteases) Type de document : texte imprimé Auteurs : Dong-hwan Lee, Auteur ; Bum-chun Lee, Auteur ; Eun-jeong Yoon, Auteur ; Kyung-eun Lee, Auteur ; Sung-min Park, Auteur ; Hyeong-bae Pyo, Auteur ; Tae-boo Choe, Auteur Année de publication : 2004 Article en page(s) : p. 227-231 Note générale : Bibliogr. Langues : Anglais (eng) Tags : MMP UVA 'Extraits de plante' 'Tussilago farfara' 'Dicentra spectabilis' Index. décimale : 668.5 Parfums et cosmétiques Résumé : The effects of several natural products on in vitro MMP-1 activity and UVA-induced MMP-1 synthesis in human dermal fibroblast (HDF) cultures were studied with the aim of developing novel anti-aging agents from natural sources. We measured MMP-1 activities by fluorescence assay using gelatin as substrates. In addition, UVA-induced MMP-1 expression was analyzed by enzyme-linked immunosorbent assay (ELISA) and gelatin-based zymography in HDF cultures, and RT-PCR techniques were used. The results showed a strong inhibitory effect of the extracts of Dicentra spectabilis and of the flower buds of Tussilago farfara. In a concentration of 0.05% (w/v), the extracts of the flower buds of Tussilago farfara and of Dicentra spectabilis inhibited MMP-1 activity by 92 and 87% respectively. At 0.1% (w/v), the extracts of the flower buds of Tussilago farfara and of Dicentra spectabilis suppressed the UVA-induced expression of MMP-1 by an amount similar to that with Vitamin C 200 μm. These results suggest that the extracts of Dicentra spectabilis and of the flower buds of Tussilago farfara effectively protect skin from UV-induced photoaging. Therefore, the extracts are thought to have potential as effective raw materials for anti-aging cosmetics. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10480
in IFSCC MAGAZINE > Vol. 7, N° 3 (07-08-09/2004) . - p. 227-231[article]Réservation
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