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Cosmetic product safety old friend or new foe ? / Stephen Kirk in PERSONAL CARE EUROPE, Vol. 5, N° 2 (04/2012)
[article]
Titre : Cosmetic product safety old friend or new foe ? Type de document : texte imprimé Auteurs : Stephen Kirk, Auteur Année de publication : 2012 Article en page(s) : p. 81-83 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Cosmétiques -- Toxicologie
Evaluation du risque
Ingrédients cosmétiquesTags : 'Enzymes protéolytiques' 'Facteurs croissance peptidiques' 'Inhibiteurs enzyme' Index. décimale : 668.5 Parfums et cosmétiques Résumé : The introduction of cosmetic ingredients with novel biological activities, such as proteolytic enzymes, peptide growth factors and enzyme inhibitors should be viewed as challenging the established dogma of the toxicological evaluation of cosmetic ingredients and finished products. In the case of peptide growth factors and enzyme inhibitors for example, in the absence of firm evidence to the contrary, perturbing such natural processes must surely be viewed as having potential negative effects on the normal homeostatic mechanisms of the skin. This is great challenge for the safety assessment of cosmetic ingredients and finished products in the 21 st century. Note de contenu : - Epidermal growth factor
- Enzyme 5-α reductase inhibitorsPermalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=14533
in PERSONAL CARE EUROPE > Vol. 5, N° 2 (04/2012) . - p. 81-83[article]Réservation
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Code-barres Cote Support Localisation Section Disponibilité 13834 - Périodique Bibliothèque principale Documentaires Disponible Down regulation of nuclear factor-kappaB activation in human keratinocytes by melanogenesis inhibitors / Kwang Seok Ahn in IFSCC MAGAZINE, Vol. 7, N° 1 (01-02-03/2004)
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Titre : Down regulation of nuclear factor-kappaB activation in human keratinocytes by melanogenesis inhibitors Type de document : texte imprimé Auteurs : Kwang Seok Ahn, Auteur ; Jinseon Lee, Auteur ; Yeong Shik Kim, Auteur Année de publication : 2004 Article en page(s) : p. 39-45 Note générale : Bibliogr. Langues : Anglais (eng) Tags : Kératinocyte 'Inhibiteurs de la mélanogenèse' 'Activité NK-?B' 'Cellules transfectantes' 'Lumière ultraviolette B' Index. décimale : 668.5 Parfums et cosmétiques Résumé : Liberated nuclear factor-kappaB (NF-κB) is translocated into the nucleus where it can change or alter the expression of target genes, resulting in the secretion of extracellular signaling molecules including melanotrophic factors affecting the melanocyte. In order to demonstrate the possible role of NF-κB activation on the synthesis of melanotrophic factors from the keratinocytes, the activities of NF-κB induced by melanogenesis inhibitors were determined in human HaCaT keratinocytes transfected with pNF-κB-SEAP-NPT plasmid. Transfectant cells released the secretory alkaline phosphatase (SEAP) as a transcription reporter in response to the NF-kB activity. Melanogenesis inhibitors such as niacinamide, kojic acid, hydroquinone, resorcinol, arbutin and glycolic acid were pre-incubated with transfectant HaCaT cells for 3 h and then irradiated with ultraviolet B (UVB). Of the melanogenesis inhibitors tested, kojic acid (IC50 = 60 μM) was found to be the most potent inhibitor of UVB-upregulating NF-κB activation in transfectant HaCaT cells, which is followed by niacinamide (IC50 = 540 μM). Especially kojic acid and niacinamide effectively lowered NF-κB binding as measured by the electrophoretic mobility shift assay. Furthermore, these two inhibitors remarkably reduced the secretion level of IL (interleukin)-6, one of the melanotrophic factors, triggered by UV radiation of the HaCaT cells. These observations suggest that melanogenesis inhibitors working at the in vivo level might act partially through the modulation of the synthesis of melanotrophic factors in keratinocytes. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10544
in IFSCC MAGAZINE > Vol. 7, N° 1 (01-02-03/2004) . - p. 39-45[article]Réservation
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Code-barres Cote Support Localisation Section Disponibilité 003882 - Périodique Bibliothèque principale Documentaires Disponible