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Dandruff lesional scalp skin exhibits epidermal T cell infiltration and a weakened hair follicle immune privilege / Susan L. Limbu in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 46, N° 5 (10/2024)
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Titre : Dandruff lesional scalp skin exhibits epidermal T cell infiltration and a weakened hair follicle immune privilege Type de document : texte imprimé Auteurs : Susan L. Limbu, Auteur ; Talveen S. Purba, Auteur ; Matthew Harries, Auteur ; Rhia Kundu, Auteur ; Ranjit K. Bhogal, Auteur ; Ralf Paus, Auteur Année de publication : 2024 Article en page(s) : p. 717-733 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Cheveux -- Croissance
Cuir chevelu -- Maladies
Dermatologie
Peau -- analyse
Peau -- Anatomie
Peau -- Physiologie
Pellicules (dermatologie)Tags : 'Gaine radiculaire externe suprabulbaire' 'Analyse génétique' 'Croissance des cheveux' 'Facteur inhibiteur de la migration macrophages' 'MHC classe I' 'Physiologie/structure peau' Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Dandruff is characterised by the presence of perivascular leukocytes and mild inflammation; however, the immune microenvironment of dandruff-affected scalp skin and the potential changes to the hair follicle's (HF) physiological immune privilege (HF IP) remain unknown. Here, we characterised the HF immune microenvironment and immune privilege status in dandruff-affected scalp skin.
- Methods : We assessed relevant key parameters in healthy versus dandruff-affected human scalp biopsies using quantitative immunohistomorphometry, laser capture microdissection, and RNA sequencing.
- Results : The number of epidermal CD4+ and CD8+ T cells was increased in lesional dandruff scalp skin, while the number of MHC class II+/CD1a+ Langerhans cells was decreased in the infundibulum. The number of intrafollicular and perifollicular CD4+ T cells and CD8+ T cells, perifollicular CD68+ macrophages, and tryptase+ mast cells remained unchanged. Interestingly, MHC class Ia and ß2-microglobulin protein expression were significantly increased specifically in the suprabulbar outer root sheath (ORS) compartment of dandruff-associated HFs. RNAseq analysis of laser capture micro-dissected suprabulbar ORS compartment revealed antigen presentation pathway as the top regulated canonical pathway, along with the upregulation of HF-IP genes such as HLA-C, HLA-DP, and TAP1, which are normally down-regulated in healthy HFs. Intrafollicular protein expression of known HF IP guardians (CD200 and α-MSH) and ‘danger signals’ (MICA and CXCL10) remained unaltered at the IP sites of dandruff lesional HFs compared to non-lesional and healthy HFs. Instead, the expression of macrophage migration inhibiting factor (MIF), another HF IP guardian, was reduced.
- Conclusion : Together, this work shows that dandruff is associated with epidermal T-cell infiltration and a weakened HF IP in the suprabulbar ORS of HFs in dandruff lesional scalp.Note de contenu : - MATERIALS AND METHODS :
- Collection of human tissue
- Immunofluorescence and imaging
- Quantitative immunohistomorphometry
- Statistical analysis
- Laser capture microdissection
- RNA extraction and quality control
- RNA library preparation and sequencing
- RNA sequencing data analysis and gene expression analysis
- RESULTS :
- CD4+ and CD8+ T cells are increased in dandruff scalp epidermis
- MHC class II+/CD1a+ Langerhans cells are decreased in the infundibulum of dandruff-associated scalp hair follicles
- Perifollicular macrophage and tryptase+ mast cells numbers remain unchanged in dandruff-associated hair follicles
- The immune privilege status is weakened in the suprabulbar ORS of dandruff lesional hair follicles
- Genes involved in antigen presentation pathway are upregulated in the suprabulbar ORS of dandruff lesional hair follicles
- The ‘danger signal’, MICA, is upregulated in the infundibulum of non-lesional HFs associated with dandruff
- Expression of locally produced HF IP guardians is altered in dandruff-associated hair folliclesDOI : https://doi.org/10.1111/ics.12956 En ligne : https://drive.google.com/file/d/1Kp42NarPKE7OTyxJ78-JT3JMWoWE7dGh/view?usp=drive [...] Format de la ressource électronique : Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=41566
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 46, N° 5 (10/2024) . - p. 717-733[article]Exemplaires
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