Water in cosmetics and Caenorhabditis elegans as an alternative model for lifespan assessment / Myriam Richaud in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 46, N° 1 (02/2024)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 46, N° 1 (02/2024) . - p. 96-105 Titre : Water in cosmetics and Caenorhabditis elegans as an alternative model for lifespan assessment Type de document : texte imprimé Auteurs : Myriam Richaud, Auteur ; Sarah Rasasombat, Auteur ; Pierre Cuq, Auteur ; Simon Galas, Auteur ; Gilberte Marti-Mestres, Auteur Année de publication : 2024 Article en page(s) : p. 96-105 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Caenorhabditis elegans Caenorhabditis elegans (C. elegans en abrégé) est un petit ver d'un millimètre environ, transparent et non parasitaire. C'est un nématode de la famille des Rhabditidae. Ce ver est devenu un organisme modèle en biologie, car il permet l'étude, entre autres, de l'apoptose (mort programmée de certaines cellules), du développement embryonnaire et du vieillissement. C. elegans est un organisme modèle dans l’étude génétique. Il est, notamment, très utilisé en raison de sa transparence, son court cycle de reproduction (3,5 jours) ainsi que sa grande facilité de manipulation. (Wikipedia) Cosmétiques Eau Formulation (génie chimique) -- Stabilité Justification de l'allégation Longévité Tests de sécurité Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Water, often considered a fundamental component of life, is the most commonly used ingredient in the formulation of dermocosmetic products, with waterless products being the exception. Dermocosmetic products can contain anywhere from 50% to 85% water, which contributes to their texture and specific characteristics. The chemical composition of water varies depending on its origin and can be categorized as highly mineralized or low mineralized. These compositions could impact the water's efficacy in anti-aging applications. In this study, the objective is evaluating the anti-aging properties of highly and low mineralized water with the model organism Caenorhabditis elegans. - Methods : In this article, we employed the alternative model organism C. elegans to assess the impact of 5 branded waters, one physiological water and one ultra-pure water on the model's lifespan, using the survival medium conventionally used for C. elegans as a comparison. Results Waters may have either a positive or a negative impact on the C. elegans lifespan expectancy. Our results indicate that only one of the water brands we assessed (Volvic®) had a significantly positive effect on worm longevity. In contrast, we found that two other brands (Hepar® and Contrex®) had a negative impact on the later stages of the worm's adulthood. Furthermore, we demonstrated that the impact of the brand water samples on lifespan expectancy varied depending on their physicochemical composition, in particular when ion concentrations were most extreme. - Conclusion : This study shows that the highly mineralized waters studied have a detrimental effect on the survival of C. elegans, and a preliminary test with ultra-pure water could not be completed due to its deleterious effect on the worms. This suggests the hypothesis that both highly mineralized and completely demineralized waters may not be the most suitable for skin formulations. Note de contenu : - MATERIALS AND METHODS : Materials - Worm culture - Lifespan experiments - RESULTS : The C. elegans lifespan can be modified by waters - Positive impact on longevity - No impact or negative impact on longevity - The brand water composition may explain the observed impact variations on the C. elegans longevity - Table 1 : Ionic composition of studied waters - Table 2 : Water-dependent lifespan modulation of Caenorhabditis elegans DOI : https://doi.org/10.1111/ics.12912 En ligne : https://drive.google.com/file/d/1q-bvwSkh2k-GOsjoauTNVNR64G2AK0lW/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=40582 [article]

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