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Sebum regulation activity of mangifera indica for multiple skin ethnicities : A biological evaluation / Chloé Boira in SOFW JOURNAL, Vol. 148, N° 9 (09/2022)
[article]
Titre : Sebum regulation activity of mangifera indica for multiple skin ethnicities : A biological evaluation Type de document : texte imprimé Auteurs : Chloé Boira, Auteur ; Morgane de Tollenaere, Auteur ; Emilie Chapuis, Auteur ; Laura Lapierre, Auteur ; Bénédicte Sennelier-Portet, Auteur ; Jessy Martinez, Auteur ; Amandine Scandolera, Auteur ; Romain Reynaud, Auteur Année de publication : 2022 Article en page(s) : p. 16-20 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Acné L'acné (nom féminin) est une dermatose (maladie de la peau) inflammatoire des follicules pilosébacés (glandes sécrétant le sébum, à la racine des poils) avec formation de comédons.
Cette maladie de la peau est représentée dans sa forme la plus fréquente par l'acné polymorphe juvénile qui touche les adolescents, mais qui ne résume pas toutes les acnés. Il existe aussi des acnés exogènes d'origine professionnelle, médicamenteuse, cosmétique...
Cosmétiques
Dermo-cosmétologie
Extraits de plantes:Extraits (pharmacie)
Lipogénèse
Peau -- Soins et hygiène
Séborrhée
Sécrétion -- RégulationIndex. décimale : 668.5 Parfums et cosmétiques Résumé : Oily skin is one of the most common issue in the cosmetic field and concern both teenagers and adults from all ethnicities. Unfortunately, the current irritating treatments lead to skin dryness, sebaceous gland atrophy and impact the skin barrier integrity. The aim of this study was to evaluate Mangifera indica extract as a new way to solve oily condition for Caucasian, African and Asian skins. Mangifera indica significantly reduced the production of lipids on various ethnicities on human sebocytes derived from iPS. Transcriptomic analysis on all ethnicities of several genes involved in sebum production has demonstrated that Mangifera indica significantly regulated lipogenesis on iPS-derived-human sebocytes. Ex vivo studies confirmed that Mangifera indica played on lipogenesis inhibition without impacting integrity of sebaceous glands. Finally, we confirmed at the clinical level a significant reduction of sebum production on Caucasian, Asian and African skins. Our results showed that Mangifera indica is an inclusive seboregulator, efficient on the three major ethnicities through an innovative mode of action controlling lipogenesis without impacting sebaceous gland morphology. Considering that sebum overproduction is related to acne concern, our results support a role for Mangifera indica in the therapeutic strategy for prevention and treatment of acne. Note de contenu : - MATERIALS & METHODS : In vitro lipogenesis inhibition in sebocytes derived from iPS - Identification of the mode of action by qPCR - Ex vivo sebum release inhibition in sebaceous gland - Clinical investigation - Statistical analysis
- RESULTS : Inhibition of sebum production on human sebocytes IPS from caucasian, asian and african origins - Elucidation of mode of action related to sebo-regulation property - Sebaceous gland volume reduction analysis - Integrity of the sebaceous glands - Impact of mangifera indica at 1% on caucasian volunteers - Impact of mangifera indica at 2% on asian volunteers - Impact of mangifera indica at 2% on african volunteersEn ligne : https://drive.google.com/file/d/11wyw3RvpVLSJmR0EuwnEOnBcZACZfyCi/view?usp=drive [...] Format de la ressource électronique : Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=38058
in SOFW JOURNAL > Vol. 148, N° 9 (09/2022) . - p. 16-20[article]Réservation
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Code-barres Cote Support Localisation Section Disponibilité 23576 - Périodique Bibliothèque principale Documentaires Disponible Sunshine in a bottle : Harnessing the power of persicaria tinctoria extract for radiant skin and enhanced well-being / Morgane de Tollenaere in SOFW JOURNAL, Vol. 150, N° 7-8 (07-08/2024)
[article]
Titre : Sunshine in a bottle : Harnessing the power of persicaria tinctoria extract for radiant skin and enhanced well-being Type de document : texte imprimé Auteurs : Morgane de Tollenaere, Auteur ; Anaïs Durduret, Auteur ; Emilie Chapuis, Auteur ; Jessy Martinez, Auteur ; Bénédicte Sennelier-Portet, Auteur ; Amandine Scandolera, Auteur ; Romain Reynaud, Auteur Année de publication : 2024 Article en page(s) : p. 8-14 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Bien-être
Cosmétiques
Dermo-cosmétologie
Etudes cliniques
Evaluation
Extraits de plantes:Extraits (pharmacie)
Mélamine -- Synthèse
Neurocosmétique
Peau -- Soins et hygiène
Persicaria tinctoria
Vitamine D -- SynthèseIndex. décimale : 668.5 Parfums et cosmétiques Résumé : Givaudan Active Beauty has developed an ingredient derived from Persicaria tinctoria, a botanical species of the buckwheat family, with the purpose of replicating the positive effects of sunlight. This innovative extract is designed to promote well-being and stimulate tanning without the need for actual sun exposure. Its main focus is to address the mood changes that occur during seasonal transitions, particularly in winter, when there is limited sun exposure and lower levels of vitamin D3. Givaudan conducted extensive research using in vitro models of keratinocytes and melanocytes that were co-cultured and ex vivo models to evaluate the pro-pigmenting activity. β-endorphin and oxytocin were quantified in the culture medium of keratinocytes stimulated with the extract. Vitamin D3 production was measured after the grinding of skin explants treated for several days with Persicaria tinctoria extract.
Finally, clinical trials were conducted to demonstrate the extract’s ability to enhance mood and improve skin health. Corroborating the hypothesis that the extract can act as a “molecular sun”, the results demonstrated its ability to significantly increase melanin content up to +66% in skin explants in comparison with placebo cream. In keratinocytes stimulated with the extract, β-endorphins increased by +43% and oxytocin by +229%. Vitamin D3 production rose significantly to 86.5%. A positive effect on mood was confirmed in vivo in a panel of volunteers who fill specific questionnaires and said they observed a significant reduction of tiredness and an increase of affectionate mood state, leading to an overall improvement of low mood.
In summary, Persicaria tinctoria extract offers myriad of sun-mimicking benefits including tanning activity, mood-enhancement and vitamin D3 stimulation. This can help address vitamin D deficiency and support overall skin and body health, particularly in regions and seasons with limited sunlight.Note de contenu : - MATERIALS AND METHODOLOGY : Evaluating pro-pigmenting activity in vitro - Evaluating pro-pigmenting activity on skin explants using Fontana Masson's staining - Enhanced positive mood and well-being : Quantifying beta-endorphin release in keratinocytes - Enhancement of positive mood and well-being : Quantifying oxytocin release in keratinocytes - Enhanced positive mood and well-being : Quantifying vitamin D3 in skin explants - Clinical evaluation of the mood-boosting properties of Persicaria tinctoria extract
- RESULTS : Sun-like effects of Persicaria tinctoria extract - Clinical study on mood-enhancement - Tiredness reduction, improved mood and improved feelings of affectionEn ligne : https://drive.google.com/file/d/1tYgaB-ZUiZkIvrNENqI-gX9rwJnHe0XL/view?usp=drive [...] Format de la ressource électronique : Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=41326
in SOFW JOURNAL > Vol. 150, N° 7-8 (07-08/2024) . - p. 8-14[article]Réservation
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Code-barres Cote Support Localisation Section Disponibilité 24739 - Périodique Bibliothèque principale Documentaires Disponible